Cited by 2,922Cancer Cells and MetastasisBreast Cancer Treatment StudiesMechanisms of cancer metastasis

Genes that mediate breast cancer metastasis to lung

Open access
Minn, Andy J., Gupta, Gaorav P., Siegel, Peter M., Bos, Paula D., Shu, Weiping, Giri, Dilip D., Viale, Agnes, Olshen, Adam B. +2 more·2005·Nature

Abstract

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

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Crossref · 10.1038/nature03799

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  • CXCL1 expression is associated with lung relapse in breast tumors, including tumors not exposed to prior chemotherapy, and increases aggressiveness of circulating breast tumor cells.

    “CXCL1 emerged among a set of genes whose expression is associated with lung relapse in breast tumors, including tumors that had not been exposed to prior chemotherapy (Minn et al., 2007; Minn et al., 2005), and as a gene that increases the aggressiveness of circulating breast tumor cells (Kim et al., 2009).”

    From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Minn et al., 2005

  • Fascin, part of a lung metastasis gene signature, does not show the same trend upon chemotherapy treatment as S100A8/9, confirming specificity of the association of S100A8/9 with chemotherapy resistance.

    “In contrast, Fascin that is part of a lung metastasis gene signature (Minn et al., 2005) did not show the same trend upon chemotherapy treatment as S100A8/9 (Figure S5E), further confirming the specificity of the association of S100A8/9 with chemotherapy resistance.”

    From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Minn et al., 2005

  • MDA-MB-231-LM2 (LM2) is an ideal xenograft model for studying tumor growth and lung metastasis.

    “which is an ideal xenograft model for studying tumor growth and lung metastasis47.”

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Authors
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Massagué, Joan
Venue
Nature
Published
2005-07-28
Volume
436
Issue
7050
Pages
518-524
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2082833890
Cited by
2,922
References
35
Citations by year
2026: 33 · 2025: 80 · 2024: 99 · 2023: 185 · 2022: 89 · 2021: 148 · 2020: 128 · 2019: 151 · 2018: 122 · 2017: 152 · 2016: 175 · 2015: 175 · 2014: 162 · 2013: 159 · 2012: 184
FWCI
57.37
Type
journal article
Language
en
Open access
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
National Cancer Institute (P01CA094060)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords
breast cancer, lung metastasis, metastasis-associated genes, gene expression signatures, tumor microenvironment, extracellular proteins, prognostic factors, therapeutic target, in vivo selection
MeSH terms
Breast Neoplasms, Humans, Lung Neoplasms, Neoplasm Metastasis, RNA, Neoplasm, Transcription, Genetic, Reproducibility of Results, Gene Expression Regulation, Neoplastic, Gene Expression Profiling, Cell Line, Tumor

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