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Intercellular calcium signaling mediated by point-source burst release of ATP
Open accessAbstract
Calcium signaling, manifested as intercellular waves of rising cytosolic calcium, is, in many cell types, the result of calcium-induced secretion of ATP and activation of purinergic receptors. The mechanism by which ATP is released has hitherto not been established. Here, we show by real-time bioluminescence imaging that ATP efflux is not uniform across a field of cells but is restricted to brief, abrupt point-source bursts. The ATP bursts emanate from single cells and manifest the transient opening of nonselective membrane channels, which admits fluorescent indicators of ≤1.5 kDa. These observations challenge the existence of regenerative ATP release, because ATP efflux is finite and restricted to a point source. Transient efflux of cytosolic nucleotides from a subset of cells may represent a conserved pathway for coordinating local activity of electrically nonexcitable cells, because identical patterns of ATP release were identified in human astrocytes, endothelial cells, and bronchial epithelial cells.
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Cites
Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846
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Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Self-citationDiffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334
Self-citationThe tripartite synapse: roles for gliotransmission in health and disease
Halassa, M. M., Fellin, T., & Haydon, P. G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.005 · Cited by 852
Metadata
- Authors
- Arcuino, G., Lin, J. H.-C., Takano, T., Liu, C., Jiang, L., Gao, Q., Kang, J., & Nedergaard, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-07-03
- Volume
- 99
- Issue
- 15
- Pages
- 9840-9845
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975979472
- Cited by
- 314
- References
- 1
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Arcuino, G., Lin, J. H.-C., Takano, T., Liu, C., Jiang, L., Gao, Q., Kang, J., & Nedergaard, M. (2002). Intercellular calcium signaling mediated by point-source burst release of ATP. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.152588599
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