The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity
Open accessAbstract
Significance: T cells protect the body against pathogens and cancer by recognizing specific foreign peptides on the cell surface. Because antigen recognition occurs at the junction between a migrating T cell and an antigen-presenting cell (APC), it is likely that cellular forces are generated and transmitted through T-cell receptor (TCR)-ligand bonds. Here we develop a DNA-based nanoparticle tension sensor producing the first molecular maps of TCR-ligand forces during T cell activation. We find that TCR forces are orchestrated in space and time, requiring the participation of CD8 coreceptor and adhesion molecules. Loss or damping of TCR forces results in weakened antigen discrimination, showing that T cells harness mechanics to optimize the specificity of response to ligand.
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Cites
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
Cited by
Mittelheisser, V., Gensbittel, V., Bonati, L., Li, W., Tang, L., & Goetz, J. G. (2024) · Nature Nanotechnology · doi:10.1038/s41565-023-01535-8 · Cited by 109
TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity
Qin, R., Zhang, Y., Shi, J., Wu, P., An, C., Li, Z., Liu, N., Wan, Z., Hua, T., Li, X., et al. (2025) · Cell Research · doi:10.1038/s41422-025-01077-9 · Cited by 35
Metadata
- Authors
- Liu, Y., Blanchfield, L., Ma, V. P.-Y., Andargachew, R., Galior, K., Liu, Z., Evavold, B., & Salaita, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-05-02
- Volume
- 113
- Issue
- 20
- Pages
- 5610-5615
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2347077379
- Cited by
- 329
- References
- 1
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
