The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
Open accessAbstract
Significance: Parkinson’s disease is the second most prevalent neurodegenerative disorder and is characterized by the presence in the brains of patients of proteinaceous deposits whose main component is α-synuclein. This protein interacts with membranes as part of its biological function, but this interaction also modulates its kinetics of aggregation. Here, we show that, despite the fact that α-synuclein binds to different types of membranes, it only forms amyloid fibrils in the presence of the most soluble lipids investigated here. This finding is of particular significance because it shows that modifications of the chemical properties of lipids, such as those associated with oxidation and ageing, could be a key determinant of the switch between functional and deleterious interactions between α-synuclein and membranes.
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Sardi, S. P., Viel, C., Clarke, J., Treleaven, C. M., Richards, A. M., Park, H., Olszewski, M. A., Dodge, J. C., Marshall, J., Makino, E., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616152114 · Cited by 203
Lövestam, S., Schweighauser, M., Matsubara, T., Murayama, S., Tomita, T., Ando, T., Hasegawa, K., Yoshida, M., Tarutani, A., Hasegawa, M., et al. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13110 · Cited by 183
Limegrover, C. S., Yurko, R., Izzo, N. J., LaBarbera, K. M., Rehak, C., Look, G., Rishton, G., Safferstein, H., & Catalano, S. M. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24782 · Cited by 43
Yan, S., Zhang, W., Li, X., Dutta, S., Castle, A. R., Liu, Y., Sahoo, A., Lam, C. L., Gatford, N. J. F., Hu, M. T., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101999 · Cited by 33
Metadata
- Authors
- Galvagnion, C., Brown, J. W. P., Ouberai, M. M., Flagmeier, P., Vendruscolo, M., Buell, A. K., Sparr, E., & Dobson, C. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-06-13
- Volume
- 113
- Issue
- 26
- Pages
- 7065-7070
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2443158342
- Cited by
- 308
- References
- 47
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Galvagnion, C., Brown, J. W. P., Ouberai, M. M., Flagmeier, P., Vendruscolo, M., Buell, A. K., Sparr, E., & Dobson, C. M. (2016). Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1601899113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
