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Community deworming alleviates geohelminth-induced immune hyporesponsiveness

Wammes, Linda J., Hamid, Firdaus, Wiria, Aprilianto Eddy, May, Linda, Kaisar, Maria M. M., Prasetyani-Gieseler, Margaretta A., Djuardi, Yenny, Wibowo, Heri, Kruize, Yvonne C. M., Verweij, Jaco J., de Jong, Sanne E., Tsonaka, Roula, Houwing-Duistermaat, Jeanine J., Sartono, Erliyani, Luty, Adrian J. F., Supali, Taniawati, Yazdanbakhsh, Maria·2016·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1604570113
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Abstract

Significance: Chronic helminth infections are accompanied by profound immune regulation. In humans, helminth-induced immune reactivity has not been thoroughly investigated in trial settings. We assessed the effect of anthelmintic treatment on immune responses in a whole community in a placebo-controlled randomized controlled trial. We show increased immune responses to helminth-specific as well as unrelated antigens, in parallel with decreased expression of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), which is a molecule involved in putting the brake on immune activation. Deworming seems to lead to decreased immunoregulation and increased immune responsiveness. These findings are of importance regarding the suboptimal vaccine responses in helminth-endemic areas and also in anticipating the future rise in inflammatory diseases when helminth infections are increasingly controlled.

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Metadata

Authors
Wammes, L. J., Hamid, F., Wiria, A. E., May, L., Kaisar, M. M. M., Prasetyani-Gieseler, M. A., Djuardi, Y., Wibowo, H., Kruize, Y. C. M., Verweij, J. J., de Jong, S. E., Tsonaka, R., Houwing-Duistermaat, J. J., Sartono, E., Luty, A. J. F., Supali, T., & Yazdanbakhsh, M.
Affiliations
  • Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;
  • Department of Parasitology, Faculty of Medicine, University of Indonesia, 10430 Jakarta, Indonesia;
  • Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;
  • Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2016-10-17
Volume
113
Issue
44
Pages
12526-12531
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1604570113
Cited by
71
References
1
Language
en
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor)
Funders
Royal Dutch Academy of Arts and Sciences (KNAW 05-PP-35)

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