The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma
Open accessAbstract
Significance: Host genetics, environmental factors, and EBV infection together contribute to nasopharyngeal carcinoma (NPC) development. A number of critical genetic and epigenetic events contributing to tumor development has been reported. However, the genomic alterations in NPC have not been completely deciphered. We used the whole-exome sequencing approach to study the somatic mutations in NPC, and an APOBEC-mediated mutagenesis signature was revealed. Importantly, multiple loss-of-function mutations in the NF-κB–negative regulators (NFKBIA,CYLD, and TNFAIP3) were discovered in NPC tumors, and we functionally confirmed that the NFKBIA loss-of-function mutations induce damaging effects on the WT proteins. Detection of these mutations emphasizes the critical role of NF-κB signaling in NPC tumorigenesis and provides perspectives for targeting this pathway in NPC treatment.
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Signatures of mutational processes in human cancer
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Cited by
Chen, Y.-P., Chan, A. T. C., Le, Q.-T., Blanchard, P., Sun, Y., & Ma, J. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30956-0 · Cited by 3,077
Epstein–Barr virus infection and nasopharyngeal carcinoma
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NF‐κB signaling in inflammation and cancer
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The Global Landscape of EBV-Associated Tumors
Shannon-Lowe, C., & Rickinson, A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00713 · Cited by 459
Wang, F.-H., Wei, X.-L., Feng, J., Li, Q., Xu, N., Hu, X.-C., Liao, W., Jiang, Y., Lin, X.-Y., Zhang, Q.-Y., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.02712 · Cited by 348
Metadata
- Authors
- Zheng, H., Dai, W., Cheung, A. K. L., Ko, J. M. Y., Kan, R., Wong, B. W. Y., Leong, M. M. L., Deng, M., Kwok, T. C. T., Chan, J. Y.-W., Kwong, D. L.-W., Lee, A. W.-M., Ng, W. T., Ngan, R. K. C., Yau, C. C., Tung, S., Lee, V. H.-F., Lam, K.-O., Kwan, C. K., Li, W. S., Yau, S., Chan, K.-W., & Lung, M. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-09-19
- Volume
- 113
- Issue
- 40
- Pages
- 11283-11288
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2522155417
- Cited by
- 182
- References
- 8
- FWCI
- 16.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Zheng, H., Dai, W., Cheung, A. K. L., Ko, J. M. Y., Kan, R., Wong, B. W. Y., Leong, M. M. L., Deng, M., Kwok, T. C. T., Chan, J. Y.-W., Kwong, D. L.-W., Lee, A. W.-M., Ng, W. T., Ngan, R. K. C., Yau, C. C., Tung, S., Lee, V. H.-F., Lam, K.-O., Kwan, C. K., . . . Lung, M. L. (2016). Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1607606113
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