The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Epstein–Barr virus infection and nasopharyngeal carcinoma
Open accessAbstract
Epstein–Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. The closest association with EBV infection is seen in undifferentiated nasopharyngeal carcinoma (NPC), which is endemic in the southern Chinese population. A strong association between NPC risk and the HLA locus at chromosome 6p has been identified, indicating a link between the presentation of EBV antigens to host immune cells and NPC risk. EBV infection in NPC is clonal in origin, strongly suggesting that NPC develops from the clonal expansion of a single EBV-infected cell. In epithelial cells, the default program of EBV infection is lytic replication. However, latent infection is the predominant mode of EBV infection in NPC. The establishment of latent EBV infection in pre-invasive nasopharyngeal epithelium is believed to be an early stage of NPC pathogenesis. Recent genomic study of NPC has identified multiple somatic mutations in the upstream negative regulators of NF-κB signalling. Dysregulated NF-κB signalling may contribute to the establishment of latent EBV infection in NPC. Stable EBV infection and the expression of latent EBV genes are postulated to drive the transformation of pre-invasive nasopharyngeal epithelial cells to cancer cells through multiple pathways. This article is part of the themed issue ‘Human oncogenic viruses’.
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Cancer in Africa 2018: The role of infections
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Functions of double‐negative B cells in autoimmune diseases, infections, and cancers
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Metadata
- Authors
- Tsao, S. W., Tsang, C. M., & Lo, K. W.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2017-09-11
- Volume
- 372
- Issue
- 1732
- Pages
- 20160270
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W2753803220
- Cited by
- 606
- References
- 118
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tsao, S. W., Tsang, C. M., & Lo, K. W. (2017). Epstein–Barr virus infection and nasopharyngeal carcinoma. Philosophical Transactions of the Royal Society B: Biological Sciences. https://doi.org/10.1098/rstb.2016.0270
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