The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae
Open accessAbstract
Significance: Malaria incidence has halved since 2000, with 80% of the reduction attributable to the use of insecticides, which now are under threat of resistance. Understanding the mechanisms of insecticide resistance is a key step in delaying and tackling the phenomenon. This study provides evidence of a cuticular mechanism that slows the uptake of pyrethroids, contributing to the resistance phenotype and potentially broadening resistance to multiple insecticide classes, thus providing additional challenges to resistance management. Quantitative modification of cuticular hydrocarbons is associated with increased expression of a 4G cytochrome P450 enzyme, CYP4G16, which catalyzes epicuticular hydrocarbon biosynthesis. This work improves our understanding of insecticide resistance and may facilitate the development of insecticides with greater specificity to mosquitoes and greater potency.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Averting a malaria disaster: will insecticide resistance derail malaria control?
Hemingway, J., Ranson, H., Magill, A., Kolaczinski, J., Fornadel, C., Gimnig, J., Coetzee, M., Simard, F., Roch, D. K., Hinzoumbe, C. K., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00417-1 · Cited by 562
Self-citationMultiple-Insecticide Resistance in Anopheles gambiae Mosquitoes, Southern Côte d’Ivoire
Edi, C. V. A., Koudou, B. G., Jones, C. M., Weetman, D., & Ranson, H. (2012) · Emerging Infectious Diseases · doi:10.3201/eid1809.120262 · Cited by 250
Self-citationIncreased Pyrethroid Resistance in Malaria Vectors and Decreased Bed Net Effectiveness, Burkina Faso
Toé, K. H., Jones, C. M., N’Fale, S., Ismail, H. M., Dabiré, R. K., & Ranson, H. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2010.140619 · Cited by 233 · cited 7×
“In particular, the cytochrome P450 cyp4g16 and cyp4g17 genes are overexpressed in resistant populations of both An. gambiae (18) and An. arabiensis (17) in several regions in Africa.”
BackgroundInfluentialSelf-citation
Cited by
The Role of Cytochrome P450s in Insect Toxicology and Resistance
Nauen, R., Bass, C., Feyereisen, R., & Vontas, J. (2022) · Annual Review of Entomology · doi:10.1146/annurev-ento-070621-061328 · Cited by 508
Self-citationThe Birth-and-Death Evolution of Cytochrome P450 Genes in Bees
Darragh, K., Nelson, D. R., & Ramírez, S. R. (2021) · Genome Biology and Evolution · doi:10.1093/gbe/evab261 · Cited by 27
Metadata
- Authors
- Balabanidou, V., Kampouraki, A., MacLean, M., Blomquist, G. J., Tittiger, C., Juárez, M. P., Mijailovsky, S. J., Chalepakis, G., Anthousi, A., Lynd, A., Antoine, S., Hemingway, J., Ranson, H., Lycett, G. J., & Vontas, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-07-20
- Volume
- 113
- Issue
- 33
- Pages
- 9268-9273
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2506589757
- Cited by
- 418
- References
- 3
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae. https://app.cochat.ai/papers/10.1073/pnas.1608295113
- The paper
- Balabanidou, V., Kampouraki, A., MacLean, M., Blomquist, G. J., Tittiger, C., Juárez, M. P., Mijailovsky, S. J., Chalepakis, G., Anthousi, A., Lynd, A., Antoine, S., Hemingway, J., Ranson, H., Lycett, G. J., & Vontas, J. (2016). Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1608295113
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
