The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
Open accessAbstract
Significance: We investigated the effect of PD-1 (programmed-death 1), a negative immunoreceptor, on the function of transcription factor FoxP3 + Treg cells. When a moderately down-modulated transcription factor FoxP3 knock-in mouse, which did not show any autoimmunity, was made PD-1–deficient, the mouse developed severe pancreatitis and died soon after birth. PD-1 deficiency also induced instability of Treg cell status and increased so-called ex-Treg cells, which showed the helper effector activity with self-antigen recognition. PD-1–deficient T reg cells, however, did not compromise their function but rather increased their suppressive activity. Thus, PD-1 and Treg cells mutually influence and both are required for protection from autoimmunity.
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Cites
Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749
Self-citationPathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, J. A., & Takayanagi, H. (2014) · Nature Medicine · doi:10.1038/nm.3432 · Cited by 1,153
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
Chung, Y., Tanaka, S., Chu, F., Nurieva, R. I., Martinez, G. J., Rawal, S., Wang, Y.-H., Lim, H., Reynolds, J. M., Zhou, X.-H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2426 · Cited by 1,120
Iwai, Y. (2004) · International Immunology · doi:10.1093/intimm/dxh194 · Cited by 527
Kido, M., Watanabe, N., Okazaki, T., Akamatsu, T., Tanaka, J., Saga, K., Nishio, A., Honjo, T., & Chiba, T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.042 · Cited by 119
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Cited by
Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?
Ohue, Y., & Nishikawa, H. (2019) · Cancer Science · doi:10.1111/cas.14069 · Cited by 1,041
Mitochondrial complex III is essential for suppressive function of regulatory T cells
Weinberg, S. E., Singer, B. D., Steinert, E. M., Martinez, C. A., Mehta, M. M., Martínez-Reyes, I., Gao, P., Helmin, K. A., Abdala-Valencia, H., Sena, L. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0846-z · Cited by 494
PD‐1/PD‐L1 pathway: Basic biology and role in cancer immunotherapy
Salmaninejad, A., Valilou, S. F., Shabgah, A. G., Aslani, S., Alimardani, M., Pasdar, A., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28358 · Cited by 445
Immune checkpoint inhibitors in cancer therapy: a focus on T‐regulatory cells
Sasidharan Nair, V., & Elkord, E. (2018) · Immunology & Cell Biology · doi:10.1111/imcb.1003 · Cited by 298
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
Tan, C. L., Kuchroo, J. R., Sage, P. T., Liang, D., Francisco, L. M., Buck, J., Thaker, Y. R., Zhang, Q., McArdel, S. L., Juneja, V. R., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20182232 · Cited by 258
Metadata
- Authors
- Zhang, B., Chikuma, S., Hori, S., Fagarasan, S., & Honjo, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-07-07
- Volume
- 113
- Issue
- 30
- Pages
- 8490-8495
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2467537941
- Cited by
- 166
- References
- 5
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, B., Chikuma, S., Hori, S., Fagarasan, S., & Honjo, T. (2016). Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1608873113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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