Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

Chung, Won-Suk, Verghese, Philip B., Chakraborty, Chandrani, Joung, Julia, Hyman, Bradley T., Ulrich, Jason D., Holtzman, David M., Barres, Ben A.·2016·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1609896113

Cited by (242)

Items 101–200 of 242

Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation
Carl J. Hodgetts, Jonathan P. Shine, Huw Williams, Mark Postans, Rebecca Sims, Julie H. Williams, Andrew D. Lawrence, Kim S. Graham · 2018 · Neurobiology of Aging
CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness
Natalia Lago, Fernanda Neutzling Kaufmann, María Luciana Negro‐Demontel, Daniela Alí‐Ruiz, Gabriele Ghisleni, Natalia Rego, Andrea Arcas-García, Nathalia Vitureira, Karen Jansen, Luciano M. Souza et al. · 2020 · Proceedings of the National Academy of Sciences
Phagocytic Glial Cells in Brain Homeostasis
Rena Kono, Yuji Ikegaya, Ryuta Koyama · 2021 · Cells
Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease
Gyungah Jun, Yang You, Congcong Zhu, Gaoyuan Meng, Jaeyoon Chung, Rebecca Panitch, Junming Hu, Weiming Xia, David Alan Bennett, Tatiana Foroud et al. · 2022 · Alzheimer s & Dementia
Microglial phagocytosis in Alzheimer disease
Brown, Guy C., St George-Hyslop, Peter, Paolicelli, Rosa C., Lemke, Greg · 2026 · Nature Reviews Neurology
Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease
Chantal M. Ferguson, Samuel R. Hildebrand, Bruno M.D.C. Godinho, Julianna E. Buchwald, Dimas Echeverria, Andrew H. Coles, Anastasia P. Grigorenko, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh et al. · 2024 · Alzheimer s & Dementia
Insight into the role of phosphatidylserine in complement-mediated synapse loss in Alzheimer’s disease
Dimitra Sokolova, Thomas Childs, Soyon Youngae Hong · 2021 · Faculty Reviews
The Impact of Apolipoprotein E (APOE) Epigenetics on Aging and Sporadic Alzheimer’s Disease
Madia Lozupone, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Antonio Daniele, Antonello Bellomo, Vincenzo Solfrizzi et al. · 2023 · Biology
Aβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide
Laia Montoliu‐Gaya, Sandra D. Mulder, Maaike A. C. Herrebout, Johannes C. Baayen, Sandra Villegas, Robert Veerhuis · 2018 · Molecular and Cellular Neuroscience
Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density
Michael Surala, Luna Soso-Zdravkovic, David A. D. Munro, Ali Rifat, Koliane Ouk, Imre Vida, Josef Priller, Christian Madry · 2024 · EMBO Reports
Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function
Yongjiang Li, Xiaojie Zhang, Yamin Li · 2019 · CNS Spectrums
PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity
Ben Rombaut, Sofie Kessels, Melissa Schepers, Assia Tiane, Dean Paes, Yevgeniya Solomina, Elisabeth Piccart, Daniël van den Hove, Bert Brône, Jos Prickaerts et al. · 2020 · Theranostics
Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan
Diego Iacono, Gloria C. Feltis · 2019 · Aging
Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury
Yacine Tensaouti, Tzong‐Shiue Yu, Steven G. Kernie · 2020 · PLoS ONE
Astrogenesis in the murine dentate gyrus is a life‐long and dynamic process
Júlia Schneider, Johannes Weigel, Marie‐Theres Wittmann, Pavel Švehla, Sebastian Ehrt, Fang Zheng, Tarek Elmzzahi, Julian Karpf, Lucía Paniagua‐Herranz, Onur Başak et al. · 2022 · The EMBO Journal
Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease
Adonis Sfera, Roberto Gradini, Michael Cummings, Eddie Lee Diaz, Amy I Price, Carolina Pereira Osorio · 2018 · Frontiers in Neurology
Dynamics of the Complement, Cytokine, and Chemokine Systems in the Regulation of Synaptic Function and Dysfunction Relevant to Alzheimer’s Disease
Shanya Jiang, Kiran Bhaskar · 2017 · Journal of Alzheimer s Disease
The Role of Glial Mitochondria in α-Synuclein Toxicity
Yu‐Mi Jeon, Younghwi Kwon, Myungjin Jo, Shinrye Lee, Seyeon Kim, Hyung‐Jun Kim · 2020 · Frontiers in Cell and Developmental Biology
Phenotypic heterogeneity of astrocytes in motor neuron disease
Emiliano Trías, Luis Barbeito, Koji Yamanaka · 2018 · Clinical and Experimental Neuroimmunology
Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice
Debora Cutuli, Eugenia Landolfo, Annalisa Nobili, Paola De Bartolo, Stefano Sacchetti, Doriana Chirico, Federica Marini, Luisa Pieroni, Maurizio Ronci, Marcello D’Amelio et al. · 2020 · Alzheimer s Research & Therapy
APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications
Jiajie Chen, Shuoyan Zhao, Yingying Zhou, Luyao Wang, Qin Chen, Kai Zheng · 2025 · BioScience Trends
Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?
Vecchio, Filomena Lo, Bisceglia, Paola, Imbimbo, Bruno Pietro, Lozupone, Madia, Latino, Raffaela Rita, Resta, Emanuela, Leone, Maurizio, Solfrizzi, Vincenzo, Greco, Antonio, Daniele, Antonio et al. · 2022 · Therapeutic Advances in Chronic Disease
Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion
Dresselhaus, Erica, Duerr, James M., Vincent, Fabien, Sylvain, Emily K., Beyna, Mercedes, Lanyon, Lorraine F., LaChapelle, Erik, Pettersson, Martin, Bales, Kelly R., Ramaswamy, Gayathri · 2018 · PLOS ONE
Complement as a powerful “influencer” in the brain during development, adulthood and neurological disorders
Tiffany J. Petrisko, Ángela Gómez-Arboledas, Andrea J. Tenner · 2021 · Advances in immunology
The Astrocyte–Neuron Interface: An Overview on Molecular and Cellular Dynamics Controlling Formation and Maintenance of the Tripartite Synapse
Uzma Hasan, Sandeep K. Singh · 2019 · Methods in molecular biology
Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes
Marcel Klein, Christian Lohr, Damian Droste · 2020 · Frontiers in Aging Neuroscience
Convergent effects of a functional C3 variant on brain atrophy, demyelination, and cognitive impairment in multiple sclerosis
Tina Roostaei, Shokufeh Sadaghiani, Rahil Mashhadi, Masih Falahatian, Esmaeil Mohamadi, Nina Javadian, Aria Nazeri, Rozita Doosti, Abdorreza Naser Moghadasi, Mahsa Owji et al. · 2018 · Multiple Sclerosis Journal
Apolipoprotein E in Alzheimer’s Disease: Focus on Synaptic Function and Therapeutic Strategy
Longjie Qu, Shuai Xu, Zhen Lan, Shuang Fang, Yun Xu, Xiaolei Zhu · 2024 · Molecular Neurobiology
Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice
Qinghu Yang, Da Feng Song, Zhen Xie, Guiqiong He, Juan Zhao, Zhe Wang, Zhifang Dong, Heao Zhang, Liang Yang, Ming Jiang et al. · 2021 · Progress in Neurobiology
Astrocytic function is associated with both amyloid-β and tau pathology in non-demented APOE ϵ4 carriers
Nicola Spotorno, Chloé Najac, Erik Stomrud, Niklas Mattsson, Sebastian Palmqvist, Danielle van Westen, Itamar Ronen, Oskar Hansson · 2022 · Brain Communications
Schizophrenia: Complement Cleaning or Killing
Jirrine T.T. Hogenaar, Hans van Bokhoven · 2021 · Genes
Single cell RNA sequencing confirms retinal microglia activation associated with early onset retinal degeneration
Asha Kumari, Raúl Ayala-Ramírez, Juan Carlos Zenteno, Kristyn Huffman, Roman Šášik, Radha Ayyagari, Shyamanga Borooah · 2022 · Scientific Reports
Complement therapeutics in neurodegenerative diseases
Wioleta Milena Zelek, Andrea J. Tenner · 2025 · Immunobiology
As a Potential Therapeutic Target, C1q Induces Synapse Loss Via Inflammasome-activating Apoptotic and Mitochondria Impairment Mechanisms in Alzheimer’s Disease
Pei-Pei Guan, Tong-Qi Ge, Pu Wang · 2023 · Journal of Neuroimmune Pharmacology
Possible positive effect of the APOE ε2 allele on cognition in early to mid-adult life
Lindsey Isla Sinclair, Christopher W. Pleydell-Pearce, Ian N.M. Day · 2017 · Neurobiology of Learning and Memory
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
Youkyeong Gloria Byun, Won‐Suk Chung · 2018 · Journal of Visualized Experiments
Learning from amyloid trials in Alzheimer's disease. A virtual patient analysis using a quantitative systems pharmacology approach
Hugo Geerts, Äthan Spiros · 2020 · Alzheimer s & Dementia
Apolipoprotein E ε4 and Risk Factors for Alzheimer Disease—Let’s Talk About Sex
Dena B. Dubal, Camille Rogine · 2017 · JAMA Neurology
Retinal dysfunction in APOE4 knock‐in mouse model of Alzheimer's disease
Surabhi D. Abhyankar, Qianyi Luo, Gabriella D. Hartman, Neha S. Mahajan, Timothy W. Corson, Adrian L. Oblak, Bruce T. Lamb, Ashay Dilip Bhatwadekar · 2025 · Alzheimer s & Dementia
APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid1
Miles Berger, Mary Cooter, Alexander Scott Roesler, Stacey Chung, John Park, Jennifer L. Modliszeski, Keith W. VanDusen, J. Will Thompson, Martin Arthur Moseley, Michael J. Devinney et al. · 2020 · Journal of Alzheimer s Disease
Myelination‐ and migration‐associated genes are downregulated after phagocytosis in cultured oligodendrocyte precursor cells
Hamanaka, Gen, Hernández, Iván Coto, Takase, Hajime, Ishikawa, Hidehiro, Benboujja, Fouzi, Kimura, Shintaro, Fukuda, Norito, Guo, Shuzhen, Lok, Josephine, Lo, Eng H. et al. · 2023 · Journal of Neurochemistry
RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network
Vladimir N. Babenko, Дмитрий Александрович Смагин, N. N. Kudryavtseva · 2017 · Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics
Glia Development and Function in the NematodeCaenorhabditis elegans
Aakanksha Singhvi, Shai Shaham, Georgia Rapti · 2024 · Cold Spring Harbor Perspectives in Biology
Aberrant Synaptic Pruning in CNS Diseases: A Critical Player in HIV-Associated Neurological Dysfunction?
Zachary Watson, Shao‐Jun Tang · 2022 · Cells
The Role of Mesenchymal Stem Cells in Regulating Astrocytes-Related Synapse Dysfunction in Early Alzheimer’s Disease
Cong Liu · 2022 · Frontiers in Neuroscience
Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model
Jing Wei, Xiaokuang Ma, Antoine Nehme, Yuehua Cui, Le Zhang, Shenfeng Qiu · 2022 · Frontiers in Aging Neuroscience
Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases
Yeseong Choi, Won‐Suk Chung · 2025 · Molecular Neurodegeneration
Investigating the ability of astrocytes to drive neural network synchrony
Gregory Handy, Alla Borisyuk · 2023 · PLoS Computational Biology
BIN1 Genetic Risk Factor for Alzheimer is Sufficient to Induce Early Structural Tract Alterations in Entorhinal-Hippocampal Area and Memory-Related Hippocampal Multi-Scale Impairments
Daudin, R, Marechal, D, Golgolab, R, Wang, Q, Abe, Y, Tsurugizawa, T., Bourg, N, Sartori, M, Loe-Mie, Y, Lipecka, J et al. · 2018
New Insights into Monocyte-Derived Macrophages in Glioblastoma
Xuetong Li, Wei Gao, Xinmiao Long, Minghua Wu · 2025 · Research
Immune cells in Alzheimer’s disease: insights into pathogenesis and potential therapeutic targets
Xiaofeng Fu, Huimin Cai, Shuiyue Quan, Ziye Ren, Yuyun Xu, Longfei Jia · 2024 · Medical Review
Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery
Rushing, Blake, Rohlik, Denise, Roy, Sourav, Skaff, D., Garcia, Brandon · 2020 · Molecules
Exploring the novel role of oligodendrocyte precursor cells in phagocytosis: beyond myelinogenesis
Gen Hamanaka, Ken Arai · 2024 · Neural Regeneration Research
The complement cascade in Alzheimer’s disease: modern implications of an ancient immune protagonist
Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Bahadur Singh, Cynthia Ann Lemere · 2025 · Molecular Neurodegeneration
Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele
Xiaoyu Ji, Xinyuan Peng, Hailiang Tang, Hui Pan, W.D. Wang, Jie Wu, Jian Chen, Naili Wei · 2023 · Brain Pathology
Patient-derived iPSCs, a reliable in vitro model for the investigation of Alzheimer’s disease
Ernest Amponsah Asiamah, Ruiyun Guo, Desheng Kong, Baofeng Feng, Jingjing He, Wei Zhang, Xin Liu, Xiaofeng Du, Zhenhuan Ma, Boxin Liu et al. · 2021 · Reviews in the Neurosciences
The Contributions of the Endolysosomal Compartment and Autophagy to APOE ɛ4 Allele-Mediated Increase in Alzheimer’s Disease Risk
Ernest Amponsah Asiamah, Baofeng Feng, Ruiyun Guo, Xu Yaxing, Xiaofeng Du, Xin Liu, Jinyu Zhang, Huixian Cui, Jun Ma · 2024 · Journal of Alzheimer s Disease
Targeting ApoE–KCC2 Signaling Rescues GABAergic Synaptic Dysfunction and Depression-like Behaviors in Mice
Chengyuan Xu, Jing Liu, Mengru Guo, Jia Wang, Xianbing Bai, Chenlei Zhang, Xinyue Luan, Huailong Pei, Huan Liu, Xinyou Lv et al. · 2025 · Research
Research progress in the mechanism of acupuncture regulating microglia in the treatment of Alzheimer’s disease
Jia Liu, Jiaqi Zhou, Chong You, Haonan Xia, Yuling Gao, Yong Liu, Xiaoyang Gong · 2024 · Frontiers in Neuroscience
From Tumor Metastasis towards Cerebral Ischemia—Extracellular Vesicles as a General Concept of Intercellular Communication Processes
Xuan Zheng, Mathias Bähr, Thorsten Roland Doeppner · 2019 · International Journal of Molecular Sciences
Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models
Yang Wu, Gem Johnson, Fujie Zhao, Yin Wu, Guojun Zhao, Andrew John Brown, Shaojin You, Ming‐Hui Zou, Ping Song · 2021 · International Journal of Molecular Sciences
Fluid Biomarkers and APOE Status of Early Onset Alzheimer’s Disease Variants: A Systematic Review and Meta-Analysis
Gurjeet Kaur, Anne Poljak, Nady Braidy, John D. Crawford, Jessica Lo, Perminder Singh Sachdev · 2020 · Journal of Alzheimer s Disease
Astrocyte–Neuron Interactions in Alzheimer’s Disease
Clara Muñoz‐Castro, Alberto Serrano‐Pozo · 2024 · Advances in neurobiology
Biomarkers in Alzheimer’s Disease: Are Olfactory Neuronal Precursors Useful for Antemortem Biomarker Research?
Valeria Santillán-Morales, Norberto Rodríguez-Espinosa, Jesús Muñoz‐Estrada, Salvador Alarcón-Elizalde, Ángel Acebes, Gloria Benítez‐King · 2024 · Brain Sciences
Apolipoprotein E4 and synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic implications
Zhiying Yao, Ivan Steve Godje Godje, Bin Jiao, Lu Shen, Shilin Luo · 2026 · Ageing Research Reviews
Associations between plasma complement C1q and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: The CABLE study
Rong‐ji Xue, Pei‐Yang Gao, Yan-Ming Chen, Ying Liu, Bo Han, Yi‐Ming Huang, Yin‐Chu Mi, Rui‐Ping Cui, Yujing Lin, Zuo-Teng Wang et al. · 2025 · Journal of Alzheimer s Disease
Nature Versus Nurture: Does Proteostasis Imbalance Underlie the Genetic, Environmental, and Age-Related Risk Factors for Alzheimer’s Disease?
Elise Alexandra Kikis · 2017 · Healthcare
Decoding the Inter-Relationship between Sleep Disorders and Alzheimer’s Disease Pathogenesis
Zeba Mueed, Pankaj Kumar Rai, Mohammad Amjad Kamal, Nitesh Kumar Poddar · 2020 · CNS & Neurological Disorders - Drug Targets
Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
Roger M. Lane, Taher Darreh‐Shori, Candice Junge, Dan Xiao Li, Qingqing Yang, Amanda Edwards, Danielle L. Graham, Katrina M. Moore, Catherine Jane Mummery · 2024 · BMC Neurology
A modeling informed quantitative approach to salvage clinical trials interrupted due to COVID‐19
Hugo Geerts, Piet Hein van der Graaf · 2020 · Alzheimer s & Dementia Translational Research & Clinical Interventions
Simulating the Effects of Common Comedications and Genotypes on Alzheimer’s Cognitive Trajectory Using a Quantitative Systems Pharmacology Approach
Hugo Geerts, Äthan Spiros · 2020 · Journal of Alzheimer s Disease
Differential selectivity of microglia and astrocytes in HIV-1 gp120-induced synaptic pruning
Zachary T Watson, Silvana Valdebenito-Silva, Michael S. Spurgat, Wenjuan Ru, Junying Zheng, Mark K Maurelli, Yuejin Liang, Subo Yuan, Eliseo A. Eugenín, Shao‐Jun Tang · 2025 · Brain
Astrocytes initiate autophagic flux and maintain cell viability after internalizing non-active native extracellular α-synuclein
Fotis Andromidas, Brooke MacKinnon, Abigail J. Myers, Melanie M. Shaffer, Ayat Brahimi, Saeid Atashpanjeh, Tiana L. Vazquez, Timmy Le, Evan R. Jellison, Susan Staurovsky et al. · 2024 · Molecular and Cellular Neuroscience
The Critical Role of Autophagy and Phagocytosis in the Aging Brain
Stephen Claude Bondy, Meixia Wu · 2024 · International Journal of Molecular Sciences
A Novel Phagocytic Role of Astrocytes in Activity-dependent Elimination of Mature Excitatory Synapses
Tong Luo, Tianming Gao · 2021 · Neuroscience Bulletin
Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life
Lindsey Isla Sinclair, Seth Love · 2017 · Journal of Alzheimer s Disease
Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies
Siddhant Tripathi, Yashika Sharma, Dileep Kumar · 2024 · Current Protein and Peptide Science
Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease
Eleonora M. Vromen, Senne B. Lageman, Johan Gobom, Rik van der Kant, Valerija Dobričić, Lars Bertram, Johannes Rolf Streffer, Simon Lovestone, Stephanie J. B. Vos, Mikel Tainta et al. · 2025 · Alzheimer s & Dementia
Tract-specific differences in white matter microstructure between young adult APOE ε4 carriers and non-carriers: A replication and extension study
Rikki Lissaman, Thomas Matthew Lancaster, Greg D. Parker, Kim S. Graham, Andrew D. Lawrence, Carl J. Hodgetts · 2022 · Neuroimage Reports
Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1‐over‐expressing mice
Saori Kikuchihara, Shouta Sugio, Kenji F. Tanaka, Takaki Watanabe, Masanobu Kano, Yoshihiko Yamazaki, Masahiko Watanabe, Kazuhiro Ikenaka · 2018 · Journal of Neurochemistry
Enriched Environment Alleviate AD Pathological Progression by Reducing Microglia Complement Signaling in Aged Male APP / PS1 Mice
Hai‐Chao Chen, Jiaxin Cao, Yi‐Shu Zhang, Xiaomei Su, Yi‐Ting Kang, Li‐Ping Gao, Yuhong Jing · 2025 · The FASEB Journal
Identification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease
Valtteri Syvänen, Jari Koıstınaho, Šárka Lehtonen · 2024 · Expert Opinion on Drug Discovery
The Evolving View of Astrocytes.
Philip G. Haydon · 2016 · PubMed
Commentary: Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
Patrycja Dzianok, Ewa Kublik · 2020 · Frontiers in Aging Neuroscience
Glia in Neurodegenerative Disease
Gerard Crowley, David Attwell, Hemali P. Phatnani, Harald W. Sontheimer, Soyon Youngae Hong · 2024 · Cold Spring Harbor Perspectives in Biology
Alzheimer's disease pathogenesis and the role of APOE ε4 in remodeling functional gradients of the default mode network
Wenting Song, Chengbing Gong, YiFei Li, Dan Yang, Haifeng Chen, LiMoRang Tang, Yun Xu, Hui Zhao · 2025 · Journal of Alzheimer s Disease
Amyloid-β clearance: an astrocytic perspective
Jiayi Li, Zhongyue Lv, X P Chen, Fan Fu, Kaixia Yang, Guogang Lai, Hao Wu, Guomin Xie · 2026 · Frontiers in Neuroscience
Metabolic Plasticity of Astrocytes
Yana V. Gorina, Alla B. Salmina, A. I. Erofeev, Zhao Can, Anastasia V. Bolshakova, Pavel M. Balaban, Безпрозванный Илья Борисович, О. Л. Власова · 2021 · Journal of Evolutionary Biochemistry and Physiology
Apolipoprotein E (APOE) Isoforms and Neurobiology of Sporadic Alzheimer’s Disease
Anita Mollica, Giuseppe Berardino, Antonello Bellomo, Mario Altamura, Francesco Panza, Madia Lozupone · 2024 · Springer eBooks
Region-Specific Differences in the Apoe4-dependent Response to Focal Brain Injury
Sung Eun Lee, Hai‐Jie Yang, Youngjun Sung, Young‐Hoon Kim, Sun Ah Park · 2021 · Experimental Neurobiology
Research Progress of Microglia Related Role in Alzheimer’s Disease
倩张 · 2021 · Advances in Clinical Medicine
In vitro models for human neuroglia
Bas Lendemeijer, Femke M. S. de Vrij · 2025 · Handbook of clinical neurology
Emerging pathological mechanisms of Alzheimer’s disease pathogenesis: from neuroimmune interactions to intercellular communication
Rutong Wang, Yingqi Feng, Ziyu Zhou, Jiajun Jiang, Runze Zhang, Wenhui Zou, Haotian Yang, Wenbo Lv, Yang Shen · 2026 · Frontiers in Aging Neuroscience
Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease
Joseph H. McCarty · 2026 · Arteriosclerosis Thrombosis and Vascular Biology
Molecular Mechanisms of Synaptic Plasticity and Memory and Their Dysfunction in Alzheimer's Disease ☆
Gabriel S. Stephens, Jason C. You, Chia-Hsuan Fu, Jeannie Chin · 2017 · Elsevier eBooks
Herpesvirus Infections in the Human Brain: A Neural Cell Model of the Complement System Derived from Induced Pluripotent Stem Cells
Ernesto T. A. Marques, Matthew Demers, Leonardo D’Aiuto, Priscila M. S. Castanha, Jason Yeung, Joel A. Wood, Kodavali V. Chowdari, Wenxiao Zheng, Robert H. Yolken, Vishwajit Laxmikant Nimgaonkar · 2022 · Current topics in behavioral neurosciences
MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits
Yuehua Cui, Xiaokuang Ma, Jing Wei, Chang Chen, Neha Shakir, Hitesch Guirram, Zhiyu Dai, Trent R. Anderson, Deveroux Ferguson, Shenfeng Qiu · 2024 · Neural Regeneration Research
Clonal hematopoiesis as the intersection between genetics and resilience in Alzheimer’s disease
Juan López-de-Mesa-Aragón, Cristina Silva‐Buriticá, Salomón Salazar‐Londoño · 2025 · npj Dementia
Transcranial Photobiomodulation in the Treatment of Major Depression
Marcelo de Oliveira Fonseca, Cristina Pacheco Soares, Rui Mateus Joaquim, André Barciela Veras · 2019
APOEe4.Trem2*R47H Mice Show Changes in Alzheimer’s Disease-Relevant Processes in the Absence of Amyloid Plaques
Kevin P. Kotredes, Adrian L. Oblak, Ravi S. Pandey, Peter Bor‐Chian Lin, Dylan T. Garceau, Harriet M. Williams, Asli Uyar, Rita O’Rourke, Sarah O’Rourke, Cynthia M. Ingraham et al. · 2021 · Research Square