The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Oriented collagen fibers direct tumor cell intravasation
Open accessAbstract
In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).
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“ECM orientation can be further achieved by providing directional forces during or after fibril polymerization, such as by external strain, flow, or shear [21,37,38].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [21]
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Cites
1 retracted
RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296
RetractedMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
Collagen reorganization at the tumor-stromal interface facilitates local invasion
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Collagen density promotes mammary tumor initiation and progression
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C., White, J. G., & Keely, P. J. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-11 · Cited by 1,394
Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,321
Mechanical properties of hydrogels and their experimental determination
Anseth, K. S., Bowman, C. N., & Brannon-Peppas, L. (1996) · Biomaterials · doi:10.1016/0142-9612(96)87644-7 · Cited by 1,156
Effects of radiation on normal tissue: consequences and mechanisms
Stone, H. B., Coleman, C. N., Anscher, M. S., & McBride, W. H. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01191-4 · Cited by 934
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Zervantonakis, I. K., Hughes-Alford, S. K., Charest, J. L., Condeelis, J. S., Gertler, F. B., & Kamm, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210182109 · Cited by 872
Cited by
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Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Hernández, A. E. D. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,151
Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977
Self-citationSelf-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 943
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
The Extracellular Matrix Modulates the Metastatic Journey
Kai, F., Drain, A. P., & Weaver, V. M. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.026 · Cited by 561
Metadata
- Authors
- Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., Chen, L., Zhang, X., Wei, W., Liu, R., Qu, J., Jiao, Y., Austin, R. H., & Liu, L.
- Affiliations
- Chinese Academy of Sciences (CN)
- Arizona State University (US)
- Shenzhen University (CN)
- King Abdullah University of Science and Technology (SA)
- Chongqing University (CN)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-09-23
- Volume
- 113
- Issue
- 40
- Pages
- 11208-11213
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5056065
- OpenAlex
- W2464386848
- Cited by
- 376
- References
- 48
- Citations by year
- 2026: 15 · 2025: 42 · 2024: 46 · 2023: 44 · 2022: 51 · 2021: 51 · 2020: 50 · 2019: 41 · 2018: 21 · 2017: 12 · 2016: 1
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
- Funders
- State Key Development Program Basic Research China (2013CB837200)
- National Science Foundation China (11474345, 11274200)
- Beijing Natural Science Foundation (7154221)
- HHS | NIH | National Cancer Institute (U54CA143803)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- collagen fiber orientation, tumor cell intravasation, extracellular matrix, cell-matrix interactions, collective cell migration, breast cancer metastasis, MDA-MB-231 cells, Matrigel
- MeSH terms
- Biopsy, Collagen, Extracellular Matrix, Female, Humans, Neoplasm Metastasis, Neoplasms, Disease Progression, Cell Line, Tumor, Cell Proliferation, Time-Lapse Imaging
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