Cited by 376Cellular Mechanics and Interactions3D Printing in Biomedical ResearchCancer Cells and Metastasis

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Oriented collagen fibers direct tumor cell intravasation

Open access

Han, Weijing, Chen, Shaohua, Yuan, Wei, Fan, Qihui, Tian, Jianxiang, Wang, Xiaochen, Chen, Longqing, Zhang, Xixiang, Wei, Weili, Liu, Ruchuan, Qu, Junle, Jiao, Yang, Austin, Robert H., Liu, Liyu·2016·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1610347113PMC PMC5056065

Open this paper in CoChat — free account

Abstract

In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

Integrity signals

Registry

Crossref · 10.1073/pnas.1610347113

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296
Retracted
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
Collagen reorganization at the tumor-stromal interface facilitates local invasion
Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G., & Keely, P. J. (2006) · BMC Medicine · doi:10.1186/1741-7015-4-38 · Cited by 1,804
Collagen density promotes mammary tumor initiation and progression
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C., White, J. G., & Keely, P. J. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-11 · Cited by 1,394
Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,321
Mechanical properties of hydrogels and their experimental determination
Anseth, K. S., Bowman, C. N., & Brannon-Peppas, L. (1996) · Biomaterials · doi:10.1016/0142-9612(96)87644-7 · Cited by 1,156
Effects of radiation on normal tissue: consequences and mechanisms
Stone, H. B., Coleman, C. N., Anscher, M. S., & McBride, W. H. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01191-4 · Cited by 934
β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
Soto, C. A., Sigurdsson, E. M., Morelli, L., Kumar, R., Castaño, E. M., & Frangione, B. (1998) · Nature Medicine · doi:10.1038/nm0798-822 · Cited by 874
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Zervantonakis, I. K., Hughes-Alford, S. K., Charest, J. L., Condeelis, J. S., Gertler, F. B., & Kamm, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210182109 · Cited by 872
Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis
Goetz, J. G., Minguet, S., Navarro-Lérida, I., Lazcano, J. J., Samaniego, R., Calvo, E., Tello, M., Osteso-Ibáñez, T., Pellinen, T., Echarri, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.05.040 · Cited by 720
Spatial coordination between cell and nuclear shape within micropatterned endothelial cells
Versaevel, M., Grevesse, T., & Gabriele, S. (2012) · Nature Communications · doi:10.1038/ncomms1668 · Cited by 652
The biology of cell locomotion within three-dimensional extracellular matrix
Friedl, P., & Br�cker, E.-B. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050498 · Cited by 651
Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity
Théry, M., Racine, V., Piel, M., Pépin, A., Dimitrov, A., Chen, Y., Sibarita, J., & Bornens, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609267103 · Cited by 623
Designer Self-Assembling Peptide Nanofiber Scaffolds for Adult Mouse Neural Stem Cell 3-Dimensional Cultures
Gelain, F., Bottai, D., Vescovi, A., & Zhang, S. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000119 · Cited by 612
Collagen as a double-edged sword in tumor progression
Fang, M., Yuan, J., Peng, C., & Li, Y. (2014) · Tumor Biology · doi:10.1007/s13277-013-1511-7 · Cited by 580
Molecularly Engineered PEG Hydrogels: A Novel Model System for Proteolytically Mediated Cell Migration
Raeber, G. P., Lütolf, M. P., & Hubbell, J. A. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.050682 · Cited by 572
Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor ProgressionPreprint
Schedin, P. S., & Keely, P. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003228 · Cited by 536
Using Graphene Oxide High Near‐Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease
Li, M., Yang, X., Ren, J., Qu, K., & Qu, X. (2012) · Advanced Materials · doi:10.1002/adma.201104864 · Cited by 535
Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Trier, S. M., & Keely, P. J. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.133116 · Cited by 493
Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
Xu, J., Rodriguez, D., Petitclerc, É., Kim, J., Hangai, M., Yuen, S., Davis, G. E., & Brooks, P. C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103111 · Cited by 489
3D collagen alignment limits protrusions to enhance breast cancer cell persistence
Riching, K. M., Cox, B. L., Salick, M. R., Pehlke, C., Riching, A. S., Ponik, S. M., Bass, B. R., Crone, W. C., Jiang, Y., Weaver, A. M., et al. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.10.035 · Cited by 446
Strain-Induced Alignment in Collagen Gels
Vader, D., Kabla, A., Weitz, D. A., & Mahadevan, L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005902 · Cited by 390
Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence
Martin, L. J., & Boyd, N. F. (2008) · Breast Cancer Research · doi:10.1186/bcr1831 · Cited by 377
Metastasis: a therapeutic target for cancer
Steeg, P. S., & Theodorescu, D. (2008) · Nature Clinical Practice Oncology · doi:10.1038/ncponc1066 · Cited by 335
Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers
Wang, H., Abhilash, A. S., Chen, C. S., Wells, R. G., & Shenoy, V. B. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.09.044 · Cited by 313
Automated quantification of aligned collagen for human breast carcinoma prognosis
Bredfeldt, J. S., Liu, Y., Conklin, M. W., Keely, P. J., Mackie, T., & Eliceiri, K. W. (2014) · Journal of Pathology Informatics · doi:10.4103/2153-3539.139707 · Cited by 216
Two-Photon and Second Harmonic Microscopy in Clinical and Translational Cancer Research
Perry, S. W., Burke, R. M., & Brown, E. B. (2012) · Annals of Biomedical Engineering · doi:10.1007/s10439-012-0512-9 · Cited by 209
Transient analysis of swelling-induced large deformations in polymer gels
Lucantonio, A., Nardinocchi, P., & Teresi, L. (2012) · Journal of the Mechanics and Physics of Solids · doi:10.1016/j.jmps.2012.07.010 · Cited by 202
Cancer metastasis as a therapeutic target
Sleeman, J. P., & Steeg, P. S. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.039 · Cited by 198
Rheology of reconstituted type I collagen gel in confined compression
Knapp, D. M., Barocas, V. H., Moon, A. G., Yoo, K., Petzold, L., & Tranquillo, R. T. (1997) · Journal of Rheology · doi:10.1122/1.550817 · Cited by 192
Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model
Carey, S. P., Starchenko, A., McGregor, A. L., & Reinhart-King, C. A. (2013) · Clinical & Experimental Metastasis · doi:10.1007/s10585-013-9565-x · Cited by 174
Cerium oxide caged metal chelator: anti-aggregation and anti-oxidation integrated H2O2-responsive controlled drug release for potential Alzheimer's disease treatment
Li, M., Shi, P., Xu, C., Ren, J., & Qu, X. (2013) · Chemical Science · doi:10.1039/c3sc50697e · Cited by 166
Orientation-selective Responses in the Mouse Lateral Geniculate Nucleus
Zhao, X., Chen, H., Liu, X., & Cang, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0095-13.2013 · Cited by 156
The Effect of Nonmalignant Systemic Disease on Tolerance to Radiation Therapy
Chon, B. H., & Loeffler, J. S. (2002) · The Oncologist · doi:10.1634/theoncologist.7-2-136 · Cited by 133
Toxicity of radiotherapy in patients with collagen vascular disease
Lin, A., Abu-Isa, E. I., Griffith, K. A., & Ben‐Josef, E. (2008) · Cancer · doi:10.1002/cncr.23591 · Cited by 115
Second-harmonic generation imaging of cancer
Keikhosravi, A., Bredfeldt, J. S., Sagar, M. A. K., & Eliceiri, K. W. (2014) · Methods in cell biology · doi:10.1016/b978-0-12-420138-5.00028-8 · Cited by 108
Real-Time Microfluidic System for Studying Mammalian Cells in 3D Microenvironments
Lii, J., Hsu, W., Parsa, H., Das, A., Rouse, R., & Sia, S. K. (2008) · Analytical Chemistry · doi:10.1021/ac8000034 · Cited by 91
Mammographic density and the risk of breast cancer recurrence after breast‐conserving surgery
Cil, T. D., Fishell, E., Hanna, W. M., Sun, P., Rawlinson, E., Narod, S. A., & McCready, D. R. (2009) · Cancer · doi:10.1002/cncr.24638 · Cited by 90
Photodegradation of β-sheet amyloid fibrils associated with Alzheimer's disease by using polyoxometalates as photocatalysts
Li, M. C., Xu, C., Ren, J., Wang, E., & Qu, X. (2013) · Chemical Communications · doi:10.1039/c3cc46772d · Cited by 81
Static and dynamic light scattering from aggregating particles
Bloomfield, V. A. (2000) · Biopolymers · doi:10.1002/1097-0282(200009)54:3 · Cited by 77
Collective cancer cell invasion induced by coordinated contractile stresses
Valencia, A. M. J., Wu, P.-H., Yogurtcu, O. N., Rao, P. P., DiGiacomo, J. W., Godet, I., He, L., Lee, M.-H., Gilkes, D. M., Sun, S. X., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5874 · Cited by 76
Breast Cancer Subtype-Specific Interactions with the Microenvironment Dictate Mechanisms of Invasion
Dang, T. T., Prechtl, A. M., & Pearson, G. W. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1818 · Cited by 69
Nonlinear Optical Imaging of Cellular Processes in Breast Cancer
Provenzano, P. P., Eliceiri, K. W., Yan, L., Ada-Nguema, A. S., Conklin, M. W., Inman, D. R., & Keely, P. J. (2008) · Microscopy and Microanalysis · doi:10.1017/s1431927608080884 · Cited by 64
Topographic Modulation of the Orientation and Shape of Cell Nuclei and Their Influence on the Measured Elastic Modulus of Epithelial Cells
McKee, C. T., Raghunathan, V. K., Nealey, P. F., Russell, P., & Murphy, C. J. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.09.042 · Cited by 58
Electric Field as a Disaggregating Agent for Amyloid Fibrils
Baumketner, A. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp509213f · Cited by 37
Post-radiation changes in oral tissues - An analysis of cancer irradiation cases
Pandya, J. A., Srikant, N., Boaz, K., Manaktala, N., Kapila, S. N., & Yinti, S. R. (2014) · South Asian Journal of Cancer · doi:10.4103/2278-330x.136785 · Cited by 23
Modelling of Multicomponent Diffusion and Swelling in Protein Gels
Lu, K. (2011) · UC Research Repository (University of Canterbury) · doi:10.26021/2564 · Cited by 5

Sorted by citations

Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Hernández, A. E. D. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,151
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977
Self-citation
Self-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 943
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
The Extracellular Matrix Modulates the Metastatic Journey
Kai, F., Drain, A. P., & Weaver, V. M. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.026 · Cited by 561

See all 376

Authors: Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., Chen, L., Zhang, X., Wei, W., Liu, R., Qu, J., Jiao, Y., Austin, R. H., & Liu, L.
Affiliations: Chinese Academy of Sciences (CN)
Arizona State University (US)
Shenzhen University (CN)
King Abdullah University of Science and Technology (SA)
Chongqing University (CN)
ORCID: Han, Weijing
Chen, Shaohua
Fan, Qihui
Tian, Jianxiang
Wang, Xiaochen
Zhang, Xixiang
Wei, Weili
Liu, Ruchuan
Qu, Junle
Jiao, Yang
Austin, Robert H.
Liu, Liyu
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2016-09-23
Volume: 113
Issue: 40
Pages: 11208-11213
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1610347113
PMC: PMC5056065
OpenAlex: W2464386848
Cited by: 376
References: 48
Citations by year: 2026: 15 · 2025: 42 · 2024: 46 · 2023: 44 · 2022: 51 · 2021: 51 · 2020: 50 · 2019: 41 · 2018: 21 · 2017: 12 · 2016: 1
FWCI: 17.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 181 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
Funders: State Key Development Program Basic Research China (2013CB837200)
National Science Foundation China (11474345, 11274200)
Beijing Natural Science Foundation (7154221)
HHS | NIH | National Cancer Institute (U54CA143803)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: collagen fiber orientation, tumor cell intravasation, extracellular matrix, cell-matrix interactions, collective cell migration, breast cancer metastasis, MDA-MB-231 cells, Matrigel
MeSH terms: Biopsy, Collagen, Extracellular Matrix, Female, Humans, Neoplasm Metastasis, Neoplasms, Disease Progression, Cell Line, Tumor, Cell Proliferation, Time-Lapse Imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oriented collagen fibers direct tumor cell intravasation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks