Metabolic Regulation of T Lymphocytes

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works

Restoring function in exhausted CD8 T cells during chronic viral infection

Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,046 · see citing works

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works

Otto Warburg's contributions to current concepts of cancer metabolism

Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427 · see citing works

Macrophages, inflammation, and insulin resistance

Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,296 · see citing works

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Hardie, D. G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2249 · Cited by 2,207 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 6× · see citing works

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124 · see citing works

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103 · see citing works

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091 · see citing works

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Francisco, L. M., Salinas, V. H., Brown, K. E., Vanguri, V. K., Freeman, G. J., Kuchroo, V. K., & Sharpe, A. H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090847 · Cited by 2,072 · see citing works

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R., Freeman, G. J., Vignali, D. A. A., & Wherry, E. J. (2009) · Nature Immunology · doi:10.1038/ni.1679 · Cited by 2,062 · see citing works

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978 · see citing works

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

Parry, R. V., Chemnitz, J. M., Frauwirth, K. A., Lanfranco, A. R., Braunstein, I., Kobayashi, S. V., Linsley, P. S., Thompson, C. B., & Riley, J. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9543-9553.2005 · Cited by 1,931 · see citing works

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797 · see citing works

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Mäkelä, T. P., Alessi, D. R., & Hardie, D. G. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-28 · Cited by 1,694 · see citing works

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

Hemminki, A., Markie, D., Tomlinson, I. P. M., Avizienyte, E., Roth, S., Loukola, A., Bignell, G. R., Warren, W., Aminoff, M., Höglund, P., et al. (1998) · Nature · doi:10.1038/34432 · Cited by 1,652 · see citing works

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650 · see citing works

Adipose tissue as an endocrine organ

Galić, S., Oakhill, J. S., & Steinberg, G. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.018 · Cited by 1,649 · see citing works

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works

mTOR regulates memory CD8 T-cell differentiation

Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575 · see citing works

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Pearce, E. L., Walsh, M. C., Cejas, P. J., Harms, G. M., Shen, H., Wang, L.-S., Jones, R. G., & Choi, Y. (2009) · Nature · doi:10.1038/nature08097 · Cited by 1,559 · see citing works

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

Harding, F., McArthur, J. G., Gross, J. A., Raulet, D. H., & Allison, J. P. (1992) · Nature · doi:10.1038/356607a0 · Cited by 1,558 · see citing works

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540 · see citing works

T cell anergy

Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487 · see citing works

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483 · see citing works

The CD28 Signaling Pathway Regulates Glucose Metabolism

Frauwirth, K. A., Riley, J. L., Harris, M. H., Parry, R. V., Rathmell, J. C., Plas, D. R., Elstrom, R. L., June, C. H., & Thompson, C. B. (2002) · Immunity · doi:10.1016/s1074-7613(02)00323-0 · Cited by 1,475 · see citing works

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413 · see citing works

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

Radtke, F., Wilson, A., Stark, G., Bauer, M., van Meerwijk, J. P. M., MacDonald, H. R., & Aguet, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80054-0 · Cited by 1,393 · see citing works

Normalization of obesity-associated insulin resistance through immunotherapy

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370 · see citing works

Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

Vats, D., Mukundan, L., Odegaard, J. I., Zhang, L., Smith, K. L., Morel, C. R., Greaves, D. R., Murray, P. J., & Chawla, A. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.011 · Cited by 1,369 · cited 1× · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,359 · see citing works

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.006 · Cited by 1,355 · see citing works

mTOR differentially regulates effector and regulatory T cell lineage commitment

Delgoffe, G. M., Kole, T., Zheng, Y., Zarek, P. E., Matthews, K., Xiao, B., Worley, P., Kozma, S., & Powell, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.014 · Cited by 1,293 · see citing works

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

Jenne, D. E., Reomann, H., Nezu, J., Friedel, W., Loff, S., Jeschke, R., Müller, O., Back, W. E., & Zimmer, M. (1998) · Nature Genetics · doi:10.1038/ng0198-38 · Cited by 1,201 · see citing works

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143 · see citing works

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,103 · see citing works

Regulation and function of mTOR signalling in T cell fate decisions

Chi, H. (2012) · Nature Reviews Immunology · doi:10.1038/nri3198 · Cited by 1,035 · see citing works

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

Tan, J. T., Dudl, E. P., LeRoy, E., Murray, R. M., Sprent, J., Weinberg, K. I., & Surh, C. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161126098 · Cited by 966 · see citing works

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

Pui, J. C., Allman, D., Xu, L., DeRocco, S. E., Karnell, F. G., Bakkour, S., Lee, J. Y., Kadesch, T. R., Hardy, R. R., Aster, J. C., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80105-3 · Cited by 943 · see citing works

Hypoxia-Inducible Factor 1 (HIF-1) Pathway

Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 942 · see citing works

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

Dang, C. V., Le, A., & Gao, P. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0889 · Cited by 934 · see citing works

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

Jacobs, S. R., Herman, C. E., MacIver, N. J., Wofford, J. A., Wieman, H. L., Hammen, J. J., & Rathmell, J. C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4476 · Cited by 853 · see citing works

Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects

Ozata, M., Ozdemir, I. C., & Licinio, J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.5999 · Cited by 739 · see citing works

LXR signaling couples sterol metabolism to proliferation in the acquired immune response

Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.052 · Cited by 711 · see citing works

CD28− T cells: their role in the age-associated decline of immune function

Weng, N., Akbar, A. N., & Goronzy, J. J. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.013 · Cited by 630 · see citing works

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 604 · see citing works

Maintaining the norm: T-cell homeostasis

Jameson, S. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri853 · Cited by 597 · see citing works

Leptin in Human Physiology and Pathophysiology

Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works

Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking

Wieman, H. L., Wofford, J. A., & Rathmell, J. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0593 · Cited by 593 · see citing works

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., & Weissman, I. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80291-3 · Cited by 592 · see citing works

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

Edinger, A. L., & Thompson, C. B. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-12-0584 · Cited by 589 · see citing works

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

Rathmell, J. C., Fox, C. J., Plas, D. R., Hammerman, P. S., Cinalli, R. M., & Thompson, C. B. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7315-7328.2003 · Cited by 572 · see citing works

Leptin in Immunology

Matarese, G., Moschos, S., & Mantzoros, C. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3137 · Cited by 559 · see citing works

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

Powell, J. D., & Delgoffe, G. M. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.002 · Cited by 503 · see citing works

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

Maraskovsky, E., O’Reilly, L. A., Teepe, M., Corcoran, L. M., Peschon, J. J., & Strasser, A. (1997) · Cell · doi:10.1016/s0092-8674(00)80289-5 · Cited by 493 · see citing works

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

Rathmell, J. C., Heiden, M. G. V., Harris, M. H., Frauwirth, K. A., & Thompson, C. B. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00066-6 · Cited by 467 · see citing works

Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism

Ciofani, M., & Zúñiga‐Pflücker, J. C. (2005) · Nature Immunology · doi:10.1038/ni1234 · Cited by 466 · see citing works

IL-7 Enhances the Survival and Maintains the Size of Naive T Cells

Rathmell, J. C., Farkash, E. A., Gao, W., & Thompson, C. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6869 · Cited by 459 · see citing works

Role of Leptin in the Activation of Immune Cells

Riejos, P. F., Najib, S., Santos‐Álvarez, J., Martín-Romero, C., Pérez‐Pérez, A., González-Yanes, C., & Sánchez‐Margalet, V. (2010) · Mediators of Inflammation · doi:10.1155/2010/568343 · Cited by 432 · see citing works

Impact of Weight Loss on Inflammatory Proteins and Their Association With the Insulin Resistance Syndrome in Morbidly Obese Patients

Kopp, H. P., Kopp, C. W., Festa, A., Krzyzanowska, K., Kriwanek, S., Minar, E., Roka, R., & Schernthaner, G. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000073313.16135.21 · Cited by 427 · cited 1× · see citing works

Metabolic pathways in T cell fate and function

Gerriets, V. A., & Rathmell, J. C. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.01.010 · Cited by 425 · see citing works

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival

Wofford, J. A., Wieman, H. L., Jacobs, S. R., Zhao, Y., & Rathmell, J. C. (2007) · Blood · doi:10.1182/blood-2007-06-096297 · Cited by 424 · see citing works

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

Pua, H. H., Guo, J., Komatsu, M., & He, Y.-W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801143 · Cited by 424 · see citing works

IL-17 regulates adipogenesis, glucose homeostasis, and obesity

Zúñiga, L. A., Shen, W.-J., Joyce-Shaikh, B., Pyatnova, E. A., Richards, A. G., Thom, C., Andrade, S. M., Cua, D. J., Kraemer, F. B., & Butcher, E. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001269 · Cited by 394 · see citing works

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α.

Luo, J., Sladek, R., Carrier, J., Bader, J.-A., Richard, D., & Giguère, V. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7947-7956.2003 · Cited by 370 · see citing works

Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth

Doughty, C. A., Bleiman, B. F., Wagner, D. J., Dufort, F. J., Mataraza, J. M., Roberts, M. F., & Chiles, T. C. (2006) · Blood · doi:10.1182/blood-2005-12-4788 · Cited by 369 · see citing works

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

Procaccini, C., Rosa, V. D., Galgani, M., Abanni, L., Calı̀, G., Porcellini, A., Carbone, F., Fontana, S., Horváth, T. L., Cava, A. L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.024 · Cited by 368 · see citing works

Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells

Cham, C. M., & Gajewski, T. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4670 · Cited by 359 · see citing works

CD8 T cell dysfunction during chronic viral infection

Shin, H., & Wherry, E. J. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.06.004 · Cited by 346 · see citing works

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II

Miyamoto, S., Murphy, A. N., & Brown, J. H. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402285 · Cited by 339 · see citing works

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

Cobbold, S. P., Adams, E., Farquhar, C. A., Nolan, K. F., Howie, D., Lui, K. O., Fairchild, P. J., Mellor, A. L., Ron, D., & Waldmann, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903919106 · Cited by 336 · see citing works

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

Beverly, B., Kang, S., Lenardo, M. J., & Schwartz, R. H. (1992) · International Immunology · doi:10.1093/intimm/4.6.661 · Cited by 333 · see citing works

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

Tamás, P., Hawley, S. A., Clarke, R. G., Mustard, K. J., Green, K., Hardie, D. G., & Cantrell, D. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052469 · Cited by 328 · see citing works

Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production.

Greiner, E. F., Guppy, M., & Brand, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31720-4 · Cited by 307 · see citing works

Leptin as an immunomodulator

Procaccini, C., Jirillo, E., & Matarese, G. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.012 · Cited by 299 · see citing works

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

Powell, J. D., Lerner, C. G., & Schwartz, R. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2775 · Cited by 290 · see citing works

The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth

Tennessen, J. M., Baker, K. D., Lam, G., Evans, J. M., & Thummel, C. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.005 · Cited by 290 · see citing works

Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells

Barata, J. T., da Silva, A. B. G., Brandão, J. G., Nadler, L. M., Cardoso, A. A., & Boussiotis, V. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040789 · Cited by 283 · see citing works

Anergic T Cells Are Metabolically Anergic

Zheng, Y., Delgoffe, G. M., Meyer, C. F., Chan, W., & Powell, J. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803510 · Cited by 280 · see citing works

Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death

Li, C., Capan, E., Zhao, Y., Zhao, J., Stolz, D. B., Watkins, S. C., Jin, S., & Lu, B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5163 · Cited by 276 · see citing works

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

Hubbard, V. M., Valdor, R., Patel, B., Singh, R., Cuervo, A. M., & Macian, F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000576 · Cited by 275 · see citing works

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

Ventre, J. R., Doebber, T. W., Wu, M. S., MacNaul, K. L., Stevens, K. A., Pasparakis, M., Kollias, G. A., & Moller, D. E. (1997) · Diabetes · doi:10.2337/diab.46.9.1526 · Cited by 275 · see citing works

A role for mammalian target of rapamycin in regulating T cell activation versus anergy

Zheng, Y., Collins, S. L., Lutz, M. A., Allen, A. N., Kole, T. P., Zarek, P. E., & Powell, J. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2163 · Cited by 274 · see citing works

Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells

Kopf, H., de la Rosa, G. M., Howard, O. M. Z., & Chen, X. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.08.027 · Cited by 271 · see citing works

Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

Cui, G., Qin, X., Wu, L., Zhang, Y., Sheng, X., Yu, Q., Sheng, H., Xi, B., Zhang, J. Z., & Zang, Y. Q. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42974 · Cited by 271 · see citing works

mTOR integrates amino acid- and energy-sensing pathways

Tokunaga, C., Yoshino, K., & Yonezawa, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.07.019 · Cited by 268 · see citing works

ERRα: a metabolic function for the oldest orphan

Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · cited 3× · see citing works

Homeostasis of αβ TCR+ T cells

Marrack, P., Bender, J., Hildeman, D. A., Jordan, M. B., Mitchell, T., Murakami, M., Sakamoto, A., Schaefer, B. C., Swanson, B., & Kappler, J. W. (2000) · Nature Immunology · doi:10.1038/77778 · Cited by 245 · see citing works

Subcellular localization of hexokinases I and II directs the metabolic fate of glucose

John, S., Weiss, J. N., & Ribalet, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017674 · Cited by 239 · see citing works

The liver kinase B1 is a central regulator of T cell development, activation, and metabolism

MacIver, N. J., Blagih, J., Saucillo, D. C., Tonelli, L., Griss, T., Rathmell, J. C., & Jones, R. G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100367 · Cited by 235 · see citing works

PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention

Kaufmann, D., & Walker, B. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803771 · Cited by 229 · see citing works

Phosphatidylinositol 3-Kinase-dependent Modulation of Carnitine Palmitoyltransferase 1A Expression Regulates Lipid Metabolism during Hematopoietic Cell Growth

DeBerardinis, R. J., Lum, J. J., & Thompson, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608372200 · Cited by 221 · see citing works

Nuclear receptor ERRα and coactivator PGC-1β are effectors of IFN-γ-induced host defensePreprint

Sonoda, J., Laganière, J., Mehl, I. R., Barish, G. D., Chong, L.-W., Li, X., Scheffler, I. E., Mock, D. C., Bataille, A. R., Robert, F., et al. (2007) · Genes & Development · doi:10.1101/gad.1553007 · Cited by 218 · see citing works

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108856108 · Cited by 216 · see citing works

Distinct Roles of the Phosphatidylinositol 3-Kinase and STAT5 Pathways in IL-7-Mediated Development of Human Thymocyte Precursors

Pallard, C., Stegmann, A. P. A., van Kleffens, T., Smart, F. M., Venkitaraman, A. R., & Spits, H. (1999) · Immunity · doi:10.1016/s1074-7613(00)80052-7 · Cited by 203 · see citing works

The metabolic life and times of a T‐cell

Michalek, R. D., & Rathmell, J. C. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00911.x · Cited by 186 · cited 1× · see citing works

IL-17 in obesity and adipogenesis

Ahmed, M., & Gaffen, S. L. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.005 · Cited by 186 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215693 · Cited by 183 · see citing works

Influence of TNF-α and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans

Krogh‐Madsen, R., Plomgaard, P., Møller, K., Mittendorfer, B., & Pedersen, B. K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00471.2005 · Cited by 181 · see citing works

Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice

Chandra, R. K. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.1.13 · Cited by 179 · see citing works

IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo

Jacobs, S. R., Michalek, R. D., & Rathmell, J. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902593 · Cited by 177 · see citing works

Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease

Gatza, E., Wahl, D. R., Opipari, A. W., Sundberg, T. B., Reddy, P., Liu, C., Glick, G. D., & Ferrara, J. L. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001975 · Cited by 168 · see citing works

Genome-Wide Identification of Direct Target Genes Implicates Estrogen-Related Receptor α as a Determinant of Breast Cancer Heterogeneity

Deblois, G., Hall, J. A., Perry, M.-C., Laganière, J., Ghahremani, M., Park, M., Hallett, M. T., & Giguère, V. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1251 · Cited by 160 · see citing works

Impairment of Cell-Mediated Immunity in Mutation Diabetic Mice (db/db)

Mandel, M. A., & Mahmoud, A. A. F. (1978) · The Journal of Immunology · doi:10.4049/jimmunol.120.4.1375 · Cited by 158 · see citing works

Estrogen-Related Receptor α Is Critical for the Growth of Estrogen Receptor–Negative Breast Cancer

Stein, R. A., Chang, C., Kazmin, D. A., Way, J. M., Schroeder, T., Wergin, M., Dewhirst, M. W., & McDonnell, D. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1594 · Cited by 155 · see citing works

Human Leptin Activates PI3K and MAPK Pathways in Human Peripheral Blood Mononuclear Cells: Possible Role of Sam68

Martín-Romero, C., & Sánchez‐Margalet, V. (2001) · Cellular Immunology · doi:10.1006/cimm.2001.1851 · Cited by 150 · see citing works

Human Leptin Signaling in Human Peripheral Blood Mononuclear Cells: Activation of the JAK-STAT Pathway

Sánchez‐Margalet, V., & Martín-Romero, C. (2001) · Cellular Immunology · doi:10.1006/cimm.2001.1815 · Cited by 144 · see citing works

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8+ T Cells

Yu, Q., Erman, B., Bhandoola, A., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021765 · Cited by 143 · see citing works

Metabolic changes in activated T cells: An NMR study of human peripheral blood lymphocytes

Bental, M., & DEUTSCH, C. J. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290307 · Cited by 136 · see citing works

Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis

Altman, B. J., Jacobs, S., Mason, E. F., Michalek, R. D., Macintyre, A. N., Coloff, J. L., Ilkayeva, O., Jia, W. P., He, Y.-W., & Rathmell, J. C. (2010) · Oncogene · doi:10.1038/onc.2010.561 · Cited by 135 · see citing works

The role of low-level lactate production in airway inflammation in asthma

Ostroukhova, M., Goplen, N., Karim, Z., Michalec, L., Guo, L., Liang, Q., & Alam, R. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00221.2011 · Cited by 132 · see citing works

Identification and Validation of the Mitochondrial F1F0-ATPase as the Molecular Target of the Immunomodulatory Benzodiazepine Bz-423

Johnson, K. M., Chen, X., Boitano, A. E., Swenson, L., Opipari, A. W., & Glick, G. D. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.02.012 · Cited by 127 · see citing works

Rab7 Prevents Growth Factor-Independent Survival by Inhibiting Cell-Autonomous Nutrient Transporter Expression

Edinger, A. L., Cinalli, R. M., & Thompson, C. B. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00291-0 · Cited by 127 · see citing works

Multiple mechanisms regulate c‐myc gene expression during normal T cell activation.

Lindsten, T., June, C. H., & Thompson, C. B. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03133.x · Cited by 126 · see citing works

Interactions of diarrhea, pneumonia, and malnutrition in childhood

Schlaudecker, E. P., Steinhoff, M. C., & Moore, S. R. (2011) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328349287d · Cited by 126 · see citing works

Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes

Colombo, S. L., Palacios‐Callender, M., Frakich, N., de León, J., Schmitt, C. A., Boorn, L., Davis, N., & Moncada, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012362107 · Cited by 126 · see citing works

T- and B-Cell Abnormalities in Systemic Lupus Erythematosus

Nagy, G., Koncz, Á., & Perl, A. (2005) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v25.i2.30 · Cited by 123 · see citing works

Regulatory T Cells Interfere with Glutathione Metabolism in Dendritic Cells and T Cells

Yan, Z., Garg, S. K., & Banerjee, R. V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.189944 · Cited by 118 · see citing works

Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis

Biniecka, M., Fox, E., Gao, W., Ng, C. T., Veale, D. J., Fearon, U., & O'Sullivan, J. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30395 · Cited by 109 · see citing works

Stoffwechsel der weißen Blutzellen

Warburg, O. H., Gawehn, K., & Geissler, A.-W. (1958) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1958-0806 · Cited by 103 · see citing works

Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells

Coloff, J. L., Mason, E. F., Altman, B. J., Gerriets, V. A., Liu, T., Nichols, A., Zhao, Y., Wofford, J. A., Jacobs, S. R., Ilkayeva, O., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.179101 · Cited by 100 · see citing works

[Metabolism of leukocytes].

Warburg, O. H., Gawehn, K., & Geissler, A.-W. (1958) · PubMed · Cited by 96 · see citing works

Glucose transporter 1 expression identifies a population of cycling CD4 + CD8 + human thymocytes with high CXCR4-induced chemotaxis

Swainson, L. A., Kinet, S., Manel, N., Battini, J., Sitbon, M., & Taylor, N. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503603102 · Cited by 95 · see citing works

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis

Harty, L. C., Biniecka, M., O'Sullivan, J., Fox, E., Mulhall, K., Veale, D. J., & Fearon, U. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200245 · Cited by 94 · see citing works

LKB1 is essential for the proliferation of T‐cell progenitors and mature peripheral T cells

Tamás, P., Macintyre, A., Finlay, D., Clarke, R., Feijoo‐Carnero, C., Ashworth, A., & Cantrell, D. (2010) · European Journal of Immunology · doi:10.1002/eji.200939677 · Cited by 94 · see citing works

Child Nutrition in Developing Countries

Neumann, C. G., Gewa, C., & Bwibo, N. O. (2004) · Pediatric Annals · doi:10.3928/0090-4481-20041001-09 · Cited by 91 · see citing works

Modulation of Life and Death by the Tumor Necrosis Factor Receptor-Associated Factors (TRAFs)

Lee, N.-K., & Lee, S. Y. (2002) · BMB Reports · doi:10.5483/bmbrep.2002.35.1.061 · Cited by 90 · see citing works

Enhanced Mitochondrial Radical Production in Patients with Rheumatoid Arthritis Correlates with Elevated Levels of Tumor Necrosis Factor alpha in Plasma

Miesel, R., Murphy, M. P., & Kröger, H. (1996) · Free Radical Research · doi:10.3109/10715769609149921 · Cited by 89 · see citing works

Characterization of the metabolic phenotype of chronically activated lymphocytes

Wahl, D., Petersen, B., Warner, R. E., Richardson, B. C., Glick, G. D., & Opipari, A. (2010) · Lupus · doi:10.1177/0961203310373109 · Cited by 82 · see citing works

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice

Ventre, J., Doebber, T. W., Wu, M., MacNaul, K., Stevens, K., Pasparakis, M., Kollias, G. A., & Moller, D. E. (1997) · Diabetes · doi:10.2337/diabetes.46.9.1526 · Cited by 82 · see citing works

Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity

Xu, J., Wagoner, G., Douglas, J. C., & Drew, P. D. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008600 · Cited by 81 · see citing works

Estrogen-related receptor-α antagonist inhibits both estrogen receptor–positive and estrogen receptor–negative breast tumor growth in mouse xenografts

Chisamore, M. J., Wilkinson, H. A., Flores, O. A., & Chen, J. D. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1028 · Cited by 78 · see citing works

Controlling cell growth and survival through regulated nutrient transporter expression

Edinger, A. L. (2007) · Biochemical Journal · doi:10.1042/bj20070490 · Cited by 77 · see citing works

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

Cao, Y., Li, H., Liu, H., Zheng, C., Ji, H., & Liu, X. (2009) · Cell Research · doi:10.1038/cr.2009.141 · Cited by 75 · see citing works

Autophagic Compartments Gain Access to the MHC Class II Compartments in Thymic Epithelium

Kasai, M., Tanida, I., Ueno, T., Kominami, E., Seki, S., Ikeda, T., & Mizuochi, T. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0804087 · Cited by 72 · see citing works

Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

Tandon, P., Gallo, C. A., Khatri, S., Barger, J. F., Yepiskoposyan, H., & Plas, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013629108 · Cited by 71 · see citing works

Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells

He, S., Kato, K., Jiang, J. K., Wahl, D. R., Mineishi, S., Fisher, E. M., Murasko, D. M., Glick, G. D., & Zhang, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020107 · Cited by 68 · see citing works

Murine Lupus Susceptibility Locus Sle1c2 Mediates CD4+ T Cell Activation and Maps to Estrogen-Related Receptor γ

Perry, D. J., Yin, Y., Caza, T. N., Baker, H. V., Dozmorov, I. M., Perl, A., & Morel, L. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200411 · Cited by 67 · see citing works

Effect of leptin on activation and cytokine synthesis in peripheral blood lymphocytes of malnourished infected children

Rodrı́guez, L., Graniel, J., & Ortiz, R. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03361.x · Cited by 66 · see citing works

Normal and cancer cell metabolism: lymphocytes and lymphoma

Altman, B. J., & Dang, C. V. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08651.x · Cited by 62 · see citing works

Maintaining T Lymphocyte Homeostasis: Another Duty of Autophagy

Pua, H. H., & He, Y. (2007) · Autophagy · doi:10.4161/auto.3908 · Cited by 59 · see citing works

Nutritional Problems of Developing Countries

Brown, K. H., & Solomons, N. W. (1991) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(20)30739-x · Cited by 56 · see citing works

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes

Zhou, Q. L., Jiang, Z. Y., Holik, J., Chawla, A., Hagan, G. N., Leszyk, J., & Czech, M. (2008) · Biochemical Journal · doi:10.1042/bj20071084 · Cited by 55 · see citing works

An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking

Wieman, H. L., Horn, S. R. G.-V., Jacobs, S. R., Altman, B. J., Kornbluth, S. A., & Rathmell, J. C. (2008) · Biochemical Journal · doi:10.1042/bj20081422 · Cited by 53 · see citing works

The estrogen-related receptor alpha: the oldest, yet an energetic orphan with robust biological functions

Ranhotra, H. S. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2010.487493 · Cited by 50 · see citing works

The significance of the expression of ERRα as a potential biomarker in breast cancer

Jarząbek, K., Koda, M., Kozłowski, L., et al. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.12.005 · Cited by 49 · see citing works

Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice

Li, B., Josefsson, E., Jonsson, I., et al. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2799 · Cited by 44 · see citing works

Exogenous Amino Acids Are Essential for Interleukin-7 Induced CD8 T Cell Gowth

Pearson, C. F., SILVA, A. C. F. D., & Seddon, B. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033998 · Cited by 26 · see citing works

Notch Signaling and Development of the Hematopoietic System

Sandy, A. R., Jones, M., & Maillard, I. P. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0899-4_6 · Cited by 23 · see citing works

Increased oxidative metabolism in phytohemagglutinin-stimulated lymphocytes from patients with systemic lupus erythematosus is associated with serum SSA antibody

Benke, P. J., Drisko, J., & Ahmad, P. M. (1991) · Biochemical Medicine and Metabolic Biology · doi:10.1016/0885-4505(91)90005-6 · Cited by 12 · see citing works

Correction: Exogenous Amino Acids Are Essential for Interleukin-7 Induced CD8 T Cell Gowth

Pearson, C. F., SILVA, A. C. F. D., & Seddon, B. P. (2012) · PLoS ONE · doi:10.1371/annotation/ee9c3e82-855f-42e0-8e57-83981bc1ba16 · Cited by 9 · see citing works

Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon α

Navarro, F., Bacurau, A. V. N., Vanzelli, A. S., Meneguello, M. O., Uchida, M. C., Moraes, M. R., de Almeida, S. S., Wasinski, F., Barros, C. C., Würtele, M., et al. (2010) · Mediators of Inflammation · doi:10.1155/2010/364290 · Cited by 9 · see citing works

Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

Gergely, P., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P. E., & Perl, A. (2002) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200201)46:1 · Cited by 5 · see citing works

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Geiger, R., Rieckmann, J. C., Wolf, T., Basso, C., Feng, Y., Fuhrer, T., Kogadeeva, M., Picotti, P., Meissner, F., Mann, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.031 · Cited by 1,775 · see citing works

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ho, P.-C., Bihuniak, J. D., Macintyre, A. N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.-C., Cui, G., Micevic, G., Perales, J. C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.012 · Cited by 1,462 · see citing works

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Fulop, T., Larbi, A., Dupuis, G., Le Page, A., Frost, E. H., Cohen, A. A., Witkowski, J. M., & Franceschi, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01960 · Cited by 1,364 · see citing works

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works

A transcriptionally and functionally distinct PD-1(+) CD8(+) T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Thommen, D. S., Koelzer, V. H., Herzig, P., Roller, A., Trefny, M., Dimeloe, S., Kiialainen, A., Hanhart, J., Schill, C., Hess, C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0057-z · Cited by 1,161 · see citing works

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Leone, R. D., Zhao, L., Englert, J. M., Sun, I.-M., Oh, M.-H., Sun, I.-H., Arwood, M. L., Bettencourt, I. A., Patel, C. H., Wen, J., et al. (2019) · Science · doi:10.1126/science.aav2588 · Cited by 1,169 · see citing works

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

Sukumar, M., Liu, J., Ji, Y., Subramanian, M., Crompton, J. G., Yu, Z., Roychoudhuri, R., Palmer, D. C., Muranski, P., Karoly, E. D., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69589 · Cited by 952 · see citing works

Understanding immunosenescence to improve responses to vaccines

Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827 · see citing works

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

Peng, M., Yin, N., Chhangawala, S., Xu, K., Leslie, C. S., & Li, M. O. (2016) · Science · doi:10.1126/science.aaf6284 · Cited by 787 · see citing works

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672 · see citing works

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen

Doedens, A. L., Phan, A. T., Stradner, M. H., Fujimoto, J. K., Nguyen, J. V., Yang, E., Johnson, R. S., & Goldrath, A. W. (2013) · Nature Immunology · doi:10.1038/ni.2714 · Cited by 660 · see citing works

Monocyte-macrophages and T cells in atherosclerosis

Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646 · see citing works

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

Wagner, A., Wang, C., Fessler, J., DeTomaso, D., Avila-Pacheco, J., Kaminski, J., Zaghouani, S., Christian, E., Thakore, P., Schellhaass, B., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.045 · Cited by 524 · see citing works

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

Wei, J., Long, L., Yang, K., Guy, C., Shrestha, S., Chen, Z., Wu, C., Vogel, P., Neale, G., Green, D. R., et al. (2016) · Nature Immunology · doi:10.1038/ni.3365 · Cited by 470 · see citing works

S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate

Tyrakis, P. A., Palazon, A., Macias, D., Lee, K. L., Phan, A. T., Veliça, P., You, J., Chia, G. S., Sim, J., Doedens, A., et al. (2016) · Nature · doi:10.1038/nature20165 · Cited by 433 · see citing works

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.007 · Cited by 429 · see citing works

Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages

Chen, D., Zhang, X., Li, Z., & Zhu, B. (2021) · Theranostics · doi:10.7150/thno.51777 · Cited by 390 · see citing works

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

Henson, S. M., Lanna, A., Riddell, N. E., Franzese, O., Macaulay, R., Griffiths, S. J., Puleston, D. J., Watson, A. S., Simon, A. K., Tooze, S. A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75051 · Cited by 389 · see citing works

Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment

Zhao, Y., Shao, Q., & Peng, G. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0344-8 · Cited by 382 · see citing works

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

Tan, H., Yang, K., Li, Y., Shaw, T. I., Wang, Y., Blanco, D. B., Wang, X., Cho, J.-H., Wang, H., Rankin, S., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.010 · Cited by 372 · see citing works

Mechanisms regulating T-cell infiltration and activity in solid tumors

Lanitis, E., Dangaj, D., Irving, M., & Coukos, G. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx238 · Cited by 369 · see citing works

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Elyahu, Y., Hekselman, I., Eizenberg-Magar, I., Berner, O., Strominger, I., Schiller, M., Mittal, K., Nemirovsky, A., Eremenko, E., Vital, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw8330 · Cited by 324 · see citing works

Acetate Promotes T Cell Effector Function during Glucose Restriction

Qiu, J., Villa, M., Sanin, D. E., Buck, M. D., O’Sullivan, D., Ching, R., Matsushita, M., Grzes, K. M., Winkler, F., Chang, C.-H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.022 · Cited by 342 · see citing works

Heterogeneity in the Differentiation and Function of CD8+ T Cells

Mittrücker, H.-W., Visekruna, A., & Huber, M. (2014) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-014-0293-y · Cited by 325 · see citing works

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

Yang, Z., Fujii, H., Mohan, S. V., Goronzy, J. J., & Weyand, C. M. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130252 · Cited by 334 · see citing works

Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310 · see citing works

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

Yang, Z., Shen, Y., Oishi, H., Matteson, E. L., Tian, L., Goronzy, J. J., & Weyand, C. M. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7151 · Cited by 275 · see citing works

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

Tsai, S., Clemente-Casares, X., Zhou, A. C., Lei, H., Ahn, J. J., Chan, Y. T., Choi, O., Luck, H., Woo, M., Dunn, S. E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.003 · Cited by 272 · see citing works

Obesity Impairs the Adaptive Immune Response to Influenza Virus

Green, W. D., & Beck, M. A. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201706-447aw · Cited by 253 · see citing works

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

Ye, D., Guan, K.-L., & Xiong, Y. (2018) · Trends in Cancer · doi:10.1016/j.trecan.2017.12.005 · Cited by 242 · see citing works

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

Kabat, A. M., Harrison, O. J., Riffelmacher, T., Moghaddam, A. E., Pearson, C. F., Laing, A., Abeler-Dörner, L., Forman, S. P., Grencis, R. K., Sattentau, Q., et al. (2016) · eLife · doi:10.7554/elife.12444 · Cited by 193 · see citing works

Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy

van Bruggen, J. A. C., Martens, A. W. J., Fraietta, J. A., Hofland, T., Tonino, S. H., Eldering, E., Levin, M.-D., Siska, P. J., Endstra, S., Rathmell, J. C., et al. (2019) · Blood · doi:10.1182/blood.2018885863 · Cited by 187 · see citing works

A new link between diabetes and cancer: enhanced WNT/β-catenin signaling by high glucose

García-Jiménez, C., García-Martínez, J. M., Chocarro-Calvo, A., & De la Vieja, A. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0152 · Cited by 151 · see citing works

The correlation between the Th17/Treg cell balance and bone health

Zhu, L., Hua, F., Ding, W., Ding, K., Zhang, Y., & Xu, C. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00202-z · Cited by 146 · see citing works

Targeting T cell metabolism in the tumor microenvironment: an anti‐cancer therapeutic strategy

Yin, Z., Bai, L., Li, W., Zeng, T., Tian, H., & Cui, J. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1409-3 · Cited by 133 · see citing works

Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

Choi, I. Y., Lee, C., & Longo, V. D. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.042 · Cited by 133 · see citing works

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

Ho, P.-C., & Liu, P.-S. (2016) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-016-0109-1 · Cited by 124 · see citing works

Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ

Ho, P.-C., Meeth, K. M., Tsui, Y.-C., Srivastava, B., Bosenberg, M. W., & Kaech, S. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3461 · Cited by 126 · see citing works

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R., & Ferrucci, L. (2019) · Aging · doi:10.18632/aging.102438 · Cited by 116 · see citing works

Interleukin-7 and Immunosenescence

Nguyen, V., Mendelsohn, A., & Larrick, J. W. (2017) · Journal of Immunology Research · doi:10.1155/2017/4807853 · Cited by 96 · see citing works

Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling

Apostolidis, S. A., Rauen, T., Hedrich, C. M., Tsokos, G. C., & Crispín, J. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.483743 · Cited by 91 · see citing works

Cerebral gluconeogenesis and diseases

Yip, J., Geng, X., Shen, J., & Ding, Y. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00521 · Cited by 89 · see citing works

Powering the Immune System: Mitochondria in Immune Function and Deficiency

Walker, M. A., Volpi, S., Sims, K. B., Walter, J. E., & Traggiai, E. (2014) · Journal of Immunology Research · doi:10.1155/2014/164309 · Cited by 83 · see citing works

Th17 cell pathogenicity in autoimmune disease

Park, E., & Ciofani, M. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01535-9 · Cited by 75 · see citing works

Metabolic reprogramming: a bridge between aging and tumorigenesis

Drapela, S., Ilter, D., & Gomes, A. P. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13261 · Cited by 41 · see citing works

Abnormal Mitochondrial Physiology in the Pathogenesis of Systemic Lupus Erythematosus

Wincup, C., & Radziszewska, A. (2021) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2021.05.001 · Cited by 15 · see citing works

T cell proliferation-related genes: predicting prognosis, identifying the cold and hot tumors, and guiding treatment in clear cell renal cell carcinoma

Huang, H., Cai, Y., Hong, X., Gao, W., Tang, J., Zhang, S., & Xu, Z. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.948734 · Cited by 6 · see citing works

Research progress of T cells in cholangiocarcinoma

Wang, Z., Dai, Y., Zhou, Y., Wang, Y., Chen, P., Li, Y., Zhang, Y., Wang, X., Hu, Y., Li, H., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1453344 · Cited by 2 · see citing works

Crucial Roles of Effectors in Interactions between Horticultural Crops and Pathogens

Liu, T., Chen, Y., Tian, S., et al. (2023) · Horticulturae · doi:10.3390/horticulturae9020250 · Cited by 9 · see citing works

20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades

Orth, K., Dixon, J. E., & Bliska, J. B. (2002) · Methods in microbiology · doi:10.1016/s0580-9517(02)31021-3

324: BRCA1 as a regulator of global cell metabolism – identifying functional targets through integromic analysis

Powell, A., Savage, K., & Harkin, D. P. (2014) · European Journal of Cancer · doi:10.1016/s0959-8049(14)50289-4

Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses

Moreno‐Altamirano, M. M. B., Kolstoe, S. E., & Sánchez-García, F. J. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00095 · Cited by 133 · see citing works

Research progress on metabolic regulating cell fate

Cheng, J., Qian, D., & Ding, X. (2018) · Guoji shengwu yixue gongcheng zazhi · doi:10.3760/cma.j.issn.1673-4181.2018.04.009