The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
Open accessAbstract
The use of Cre/ loxP recombination in mammalian cells has expanded rapidly. We describe here that Cre expression in cultured mammalian cells may result in a markedly reduced proliferation and that this effect is dependent on the endonuclease activity of Cre. Chromosome analysis after Cre expression revealed numerous chromosomal aberrations and an increased number of sister chromatid exchanges. Titration experiments in mouse embryo fibroblasts with a ligand-regulatable Cre-ER T show that toxicity is dependent on the level of Cre activity. Prolonged, low levels of Cre activity permit recombination without concomitant toxicity. This urges for a careful titration of Cre activity in conditional gene modification in mammalian cells.
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Cites
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
Metzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570
Cited by
Tuveson, D. A., Shaw, A. T., Willis, N. A., Silver, D. P., Jackson, E. L., Chang, S., Mercer, K. L., Grochow, R., Hock, H., Crowley, D., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00085-6 · Cited by 798
Vagaries of conditional gene targeting
Schmidt-Supprian, M., & Rajewsky, K. (2007) · Nature Immunology · doi:10.1038/ni0707-665 · Cited by 414
Conditional mouse models of sporadic cancer
Jonkers, J., & Berns, A. (2002) · Nature Reviews Cancer · doi:10.1038/nrc777 · Cited by 294
Self-citationMdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
Francoz, S., Froment, P., Bogaerts, S., De Clercq, S., Maetens, M., Doumont, G., Bellefroid, E., & Marine, J.-C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508476103 · Cited by 260
Artus, J., Piliszek, A., & Hadjantonakis, A.-K. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.12.007 · Cited by 232
Metadata
- Authors
- Loonstra, A., Vooijs, M., Beverloo, H. B., Allak, B. A., van Drunen, E., Kanaar, R., Berns, A., & Jonkers, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-07-31
- Volume
- 98
- Issue
- 16
- Pages
- 9209-9214
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042796276
- Cited by
- 590
- References
- 2
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Loonstra, A., Vooijs, M., Beverloo, H. B., Allak, B. A., van Drunen, E., Kanaar, R., Berns, A., & Jonkers, J. (2001). Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.161269798
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