The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization
Open accessAbstract
Significance: In in vitro fertilization (IVF), current methods of diagnosing chromosome abnormality and screening for viability of transfer require biopsy of embryos, which affects embryo quality, awaits long-term biosafety test, and requires specialized skills. We demonstrate the principle of noninvasive chromosome screening (NICS), which is based on sequencing the genomic DNA secreted into the culture medium from the embryo, avoiding the need for embryo biopsy and substantially increasing the safety. By characterizing its precision and demonstrating successful live births, we validate that NICS offers the potential of significantly improving the clinical outcome of IVF.
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Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell
Zong, C., Lu, S., Chapman, A. R., & Xie, X. S. (2012) · Science · doi:10.1126/science.1229164 · Cited by 1,154
Self-citationDown syndrome phenotypes: the consequences of chromosomal imbalance.
Korenberg, J. R., Chen, X. N., Schipper, R., Sun, Z., Gonsky, R., Gerwehr, S., Carpenter, N., Daumer, C., Dignan, P., & Disteche, C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4997 · Cited by 784
Battaglia, D. E., Goodwin, P., Klein, N. A., & Soules, M. R. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019080 · Cited by 645
Scott, R. T., Upham, K. M., Forman, E. J., Hong, K. H., Scott, K. L., Taylor, D., Tao, X., & Treff, N. R. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.04.035 · Cited by 589
Yang, Z., Liu, J., Collins, G. S., Salem, S. A., Liu, X., Lyle, S. S., Peck, A. C., Sills, E. S., & Salem, R. D. (2012) · Molecular Cytogenetics · doi:10.1186/1755-8166-5-24 · Cited by 545
In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial
Forman, E. J., Hong, K. H., Ferry, K. M., Tao, X., Taylor, D., Levy, B., Treff, N. R., & Scott, R. T. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.02.056 · Cited by 497
Investigation and treatment of repeated implantation failure following IVF-ET
Margalioth, E. J., Ben-Chetrit, A., Gal, M., & Eldar-Geva, T. (2006) · Human Reproduction · doi:10.1093/humrep/del305 · Cited by 472
Single-Cell Whole-Genome Amplification and Sequencing: Methodology and Applications
Huang, L., Ma, F., Chapman, A., Lu, S., & Xie, X. S. (2015) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090413-025352 · Cited by 423
Self-citation
Metadata
- Authors
- Xu, J., Fang, R., Chen, L., Chen, D., Xiao, J.-P., Yang, W., Wang, H., Song, X., Ma, T., Bo, S., Shi, C., Ren, J., Huang, L., Cai, L.-Y., Yao, B., Xie, X. S., & Lu, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-09-29
- Volume
- 113
- Issue
- 42
- Pages
- 11907-11912
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2524720610
- Cited by
- 288
- References
- 40
- FWCI
- 29.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xu, J., Fang, R., Chen, L., Chen, D., Xiao, J.-P., Yang, W., Wang, H., Song, X., Ma, T., Bo, S., Shi, C., Ren, J., Huang, L., Cai, L.-Y., Yao, B., Xie, X. S., & Lu, S. (2016). Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1613294113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
