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Cited by 472

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Investigation and treatment of repeated implantation failure following IVF-ET

Open access
Margalioth, E.J., Ben-Chetrit, A., Gal, M., Eldar-Geva, T.·2006·Human Reproduction

Abstract

Pregnancy rate following one cycle of IVF and ET can be as high as 60%. But even in the very successful units, some couples fail repeatedly. The causes for repeated implantation failure (RIF) may be because of reduced endometrial receptivity, embryonic defects or multifactorial causes. Various uterine pathologies, such as thin endometrium, altered expression of adhesive molecules and immunological factors, may decrease endometrial receptivity, whereas genetic abnormalities of the male or female, sperm defects, embryonic aneuploidy or zona hardening are among the embryonic reasons for failure of implantation. Endometriosis and hydrosalpinges may adversely influence both. In this mini review, we discuss the suggested methods for evaluation and treatment of RIF: repeated hysteroscopy, myomectomy, endometrial stimulation, immunotherapy, preimplantation genetic screening (PGS), assisted hatching, zygote intra-Fallopian transfer (ZIFT), co-culture, blastocyst transfer, cytoplasmic transfer, tailoring stimulation protocols and salpingectomy for hydrosalpinges.

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Metadata

Authors
Margalioth, E. J., Ben-Chetrit, A., Gal, M., & Eldar-Geva, T.
Venue
Human Reproduction
Published
2006-08-12
Volume
21
Issue
12
Pages
3036-3043
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
OpenAlex
W2118661243
Cited by
472
References
54
FWCI
4.51
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Investigation and treatment of repeated implantation failure following IVF-ET. https://app.cochat.ai/papers/10.1093/humrep/del305
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Margalioth, E. J., Ben-Chetrit, A., Gal, M., & Eldar-Geva, T. (2006). Investigation and treatment of repeated implantation failure following IVF-ET. Human Reproduction. https://doi.org/10.1093/humrep/del305

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