The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Real-time measurement of small molecules directly in awake, ambulatory animals
Open accessAbstract
Significance: The ability to monitor arbitrary molecules directly in living subjects as they undergo their daily routines remains one of the “holy grails” of bioanalytical chemistry. Such a technology would, for example, vastly improve our knowledge of physiology, pharmacokinetics, and toxicology by allowing the high-precision measurement of drugs and metabolites under realistic physiological conditions. Real-time molecular measurements would also provide an unparalleled window into health status (e.g., kidney function) and would facilitate “therapeutic drug monitoring,” in which dosing is personalized to the specific metabolism of each individual patient. Finally, the ability to measure molecules in the body in real time would provide unprecedented new routes by which drugs with dangerously narrow therapeutic windows could be safely and efficiently administered.
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Cites
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Self-citationModelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
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Accessing analytes in biofluids for peripheral biochemical monitoring
Heikenfeld, J., Jajack, A., Feldman, B., Granger, S. W., Gaitonde, S., Begtrup, G., & Katchman, B. A. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0040-3 · Cited by 758
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Flynn, C. D., Chang, D., Mahmud, A., Yousefi, H., Das, J., Riordan, K. T., Sargent, E. H., & Kelley, S. O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00067-z · Cited by 226
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Vázquez-Guardado, A., Yang, Y., Bandodkar, A. J., & Rogers, J. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00739-8 · Cited by 202
Achievements and Challenges for Real-Time Sensing of Analytes in Sweat within Wearable Platforms
Brothers, M. C., DeBrosse, M., Grigsby, C. C., Naik, R. R., Hussain, S. M., Heikenfeld, J., & Kim, S. S. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00555 · Cited by 207
Metadata
- Authors
- Arroyo-Currás, N., Somerson, J., Vieira, P. A., Ploense, K. L., Kippin, T. E., & Plaxco, K. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-01-09
- Volume
- 114
- Issue
- 4
- Pages
- 645-650
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2567786944
- Cited by
- 451
- References
- 32
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Arroyo-Currás, N., Somerson, J., Vieira, P. A., Ploense, K. L., Kippin, T. E., & Plaxco, K. W. (2017). Real-time measurement of small molecules directly in awake, ambulatory animals. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1613458114
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