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Label‐Free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer‐Based Sensor

Xiao, Yi, Lubin, Arica A., Heeger, Alan J., Plaxco, Kevin W.·2005·Angewandte Chemie International Edition
DOI 10.1002/anie.200500989
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Abstract

Blue, gold, and DNA: A methylene blue (MB) tagged, thrombin-binding DNA aptamer immobilized on a gold surface undergoes a large conformational change upon target binding (see schematic representation; eT: electron transfer). This folding produces a large, readily measurable change in redox current and allows the electrochemical detection of thrombin in blood serum.

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Metadata

Authors
Xiao, Y., Lubin, A. A., Heeger, A. J., & Plaxco, K. W.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2005-08-22
Volume
44
Issue
34
Pages
5456-5459
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
DOI
10.1002/anie.200500989
OpenAlex
W2103205961
Cited by
812
References
0
FWCI
12.10
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Label‐Free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer‐Based Sensor. https://app.cochat.ai/papers/10.1002/anie.200500989
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Xiao, Y., Lubin, A. A., Heeger, A. J., & Plaxco, K. W. (2005). Label‐Free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer‐Based Sensor. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200500989

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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