The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Matrix stiffening promotes a tumor vasculature phenotype
Open accessAbstract
Significance: Dysregulation of both vascular architecture and function is a hallmark of numerous diseases, including cancer. This dysregulation is currently largely attributed to up-regulated proangiogenic growth factors. Here, we show that the stiffness of the underlying extracellular matrix also plays a central role in promoting angiogenesis and a characteristic tumor-like vasculature both in vitro and in vivo. The matrix stiffness-mediated angiogenesis is dependent on increased matrix metalloprotease activity. In addition, increased matrix cross-linking disrupts endothelial cell–cell junctional integrity and results in leakier vasculature. These results suggest that altered tissue mechanics, which are characteristic of solid tumors, directly influence vascular phenotype and, subsequently, may impair therapeutic delivery and efficacy.
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1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
RetractedNormalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527 · cited 2×
“Notably, tumor angiogenesis is marked by increased branching and tortuosity (5).”
BackgroundThe extracellular matrix: A dynamic niche in cancer progression
Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201102147 · Cited by 3,024
Drug Resistance and the Solid Tumor Microenvironment
Tredan, O., Galmarini, C. M., Patel, K., & Tannock, I. F. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm135 · Cited by 2,116 · cited 1×
“Solid tumor tissue is typically stiffer than native, healthy tissue (1, 6).”
BackgroundHirose, A., Tanikawa, T., Mori, H., Okada, Y., & Tanaka, Y. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.11.082 · Cited by 129
Cited by
Three-dimensional in vitro cell culture models in drug discovery and drug repositioning
Langhans, S. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00006 · Cited by 1,522
Extracellular matrix and its therapeutic potential for cancer treatment
Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962
Nia, H. T., Munn, L. L., & Jain, R. K. (2020) · Science · doi:10.1126/science.aaz0868 · Cited by 855
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
The role of collagen in cancer: from bench to bedside
Xu, S., Xu, H., Wang, W., Li, S., Li, H., Li, T., Zhang, W., Yu, X., & Liu, L. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2058-1 · Cited by 735
Metadata
- Authors
- Bordeleau, F., Mason, B. N., Lollis, E. M., Mazzola, M., Zanotelli, M. R., Somasegar, S., Califano, J. P., Montague, C., LaValley, D. J., Huynh, J., Mencia-Trinchant, N., Negrón Abril, Y. L., Hassane, D. C., Bonassar, L. J., Butcher, J. T., Weiss, R. S., & Reinhart-King, C. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-12-29
- Volume
- 114
- Issue
- 3
- Pages
- 492-497
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2565401689
- Cited by
- 416
- References
- 5
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Bordeleau, F., Mason, B. N., Lollis, E. M., Mazzola, M., Zanotelli, M. R., Somasegar, S., Califano, J. P., Montague, C., LaValley, D. J., Huynh, J., Mencia-Trinchant, N., Negrón Abril, Y. L., Hassane, D. C., Bonassar, L. J., Butcher, J. T., Weiss, R. S., & Reinhart-King, C. A. (2017). Matrix stiffening promotes a tumor vasculature phenotype. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1613855114
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
