Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway
Abstract
MINT‐7301204, MINT‐7301186: RhoA (uniprotkb:P61586) physically interacts (MI:0915) with RAGE (uniprotkb:Q15109) by anti bait coimmunoprecipitation (MI:0006)
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Upon binding to their cognate receptor, AGEs trigger activation of downstream effectors including ERK1/2, p38 MAPK, rho-GTPases, JAK, JNK, and NF-kB.
“Upon binding to their cognate receptor, AGEs trigger the activation of different downstream effectors, including extracellularsignal-regulated kinase 1/2 and p38 mitogen-activated protein kinase, rho-GTPases, Janus kinase, c-Jun N-terminal kinase (JNK), and the transcription factor nuclear-factor-kappa B (NF-𝜅B).[49][50][51][52][53]”
From The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction (2021) · cites this paper as [50]
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- Authors
- Hirose, A., Tanikawa, T., Mori, H., Okada, Y., & Tanaka, Y.
- Affiliations
- University of Occupational and Environmental Health Japan (JP)
- Corresponding author
- Tanaka, Yoshiya
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-11-26
- Volume
- 584
- Issue
- 1
- Pages
- 61-66
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2052034057
- Cited by
- 129
- References
- 15
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 10 · 2016: 13 · 2015: 9 · 2014: 10 · 2013: 11 · 2012: 5
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, Labor and Welfare of Japan
- the Ministry of Education, Culture, Sports, Science and Technology of Japan
- University of Occupational and Health, Japan
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- advanced glycation end products, RAGE, RhoA, endothelial permeability, diabetic vascular disease, stress fibers, Rho kinase, cytoskeletal remodeling, AGE-BSA
- MeSH terms
- Receptor for Advanced Glycation End Products, Actins, Amides, Capillary Permeability, Cells, Cultured, Cytoskeleton, Diabetic Angiopathies, Endothelium, Vascular, Humans, Pyridines, Receptors, Immunologic, Serum Albumin, Bovine, Signal Transduction, Glycation End Products, Advanced, rhoA GTP-Binding Protein
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