Cited by 129Advanced Glycation End Products researchBarrier Structure and Function StudiesCell Adhesion Molecules Research

Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway

Hirose, Akiko, Tanikawa, Takahisa, Mori, Hiroko, Okada, Yosuke, Tanaka, Yoshiya·2010·FEBS Letters

Abstract

MINT‐7301204, MINT‐7301186: RhoA (uniprotkb:P61586) physically interacts (MI:0915) with RAGE (uniprotkb:Q15109) by anti bait coimmunoprecipitation (MI:0006)

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Crossref · 10.1016/j.febslet.2009.11.082

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16 of 16 references verified0 citation errors · 0 not checkable

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  • Upon binding to their cognate receptor, AGEs trigger activation of downstream effectors including ERK1/2, p38 MAPK, rho-GTPases, JAK, JNK, and NF-kB.

    “Upon binding to their cognate receptor, AGEs trigger the activation of different downstream effectors, including extracellularsignal-regulated kinase 1/2 and p38 mitogen-activated protein kinase, rho-GTPases, Janus kinase, c-Jun N-terminal kinase (JNK), and the transcription factor nuclear-factor-kappa B (NF-𝜅B).[49][50][51][52][53]”

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Authors
Hirose, A., Tanikawa, T., Mori, H., Okada, Y., & Tanaka, Y.
Affiliations
University of Occupational and Environmental Health Japan (JP)
Corresponding author
Tanaka, Yoshiya
Venue
FEBS Letters
Publisher
Wiley
Published
2009-11-26
Volume
584
Issue
1
Pages
61-66
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2052034057
Cited by
129
References
15
Citations by year
2026: 2 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 10 · 2016: 13 · 2015: 9 · 2014: 10 · 2013: 11 · 2012: 5
FWCI
4.26
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Health, Labor and Welfare of Japan
  • the Ministry of Education, Culture, Sports, Science and Technology of Japan
  • University of Occupational and Health, Japan
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
advanced glycation end products, RAGE, RhoA, endothelial permeability, diabetic vascular disease, stress fibers, Rho kinase, cytoskeletal remodeling, AGE-BSA
MeSH terms
Receptor for Advanced Glycation End Products, Actins, Amides, Capillary Permeability, Cells, Cultured, Cytoskeleton, Diabetic Angiopathies, Endothelium, Vascular, Humans, Pyridines, Receptors, Immunologic, Serum Albumin, Bovine, Signal Transduction, Glycation End Products, Advanced, rhoA GTP-Binding Protein

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