The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein
Open accessAbstract
Significance: The exact function of gasdermin-B, a protein involved in epithelial cell development, is unknown. We provide insights into gasdermin-B function and how it may contribute to cancer progression and genetic susceptibility to asthma and inflammatory bowel disease (IBD). In contrast to other gasdermins, which bind phosphoinositides and cardiolipin only upon cleavage between their N- and C-terminal domains, intact gasdermin-B binds phosphoinositides and, uniquely, sulfatide, a component of the apical membrane of epithelial cells. Polymorphism residues in the C-terminal domain, associated with asthma and IBD, induce structural changes that may affect protein activity. Components of the apical plasma membrane maintain the cell barrier integrity; thus, aberrant sulfatide levels due to changes in the cellular gasdermin-B concentration or activity could affect disease risk.
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Phaser crystallographic software
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An integrated map of genetic variation from 1,092 human genomes
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“A DALI search (36) revealed a single structure exhibiting the same topology: that of the cytoplasmic domain of a putative membrane protein from Clostridium difficile 630 (PDB ID code 3KMI, determined by the Midwest Structural Genomic Consortium).”
BackgroundCaspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
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Pore-forming activity and structural autoinhibition of the gasdermin family
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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
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Cited by
The gasdermins, a protein family executing cell death and inflammation
Broz, P., Pelegrín, P., & Shao, F. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0228-2 · Cited by 1,641
NLRP3 inflammasome activation and cell death
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Gasdermins: Effectors of Pyroptosis
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Newton, K., Strasser, A., Kayagaki, N., & Dixit, V. M. (2024) · Cell · doi:10.1016/j.cell.2023.11.044 · Cited by 990
Pyroptosis in inflammatory diseases and cancer
Rao, Z., Zhu, Y., Yang, P., Chen, Z., Xia, Y., Qiao, C., Liu, W., Deng, H., Li, J., Ning, P., et al. (2022) · Theranostics · doi:10.7150/thno.71086 · Cited by 800
Metadata
- Authors
- Chao, K. L., Kulakova, L., & Herzberg, O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-02
- Volume
- 114
- Issue
- 7
- Pages
- E1128-E1137
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2584952294
- Cited by
- 214
- References
- 8
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein. https://app.cochat.ai/papers/10.1073/pnas.1616783114
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- Chao, K. L., Kulakova, L., & Herzberg, O. (2017). Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1616783114
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