The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Gasdermins: Effectors of Pyroptosis
Open accessAbstract
Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD). The PFD oligomerizes to form large pores in the membrane that drive swelling and membrane rupture. Gasdermin D is one of six (in humans) gasdermin family members; several other gasdermins have also been shown to form pores that cause pyroptosis after cleavage to activate their PFDs. One of these, gasdermin E, is activated by caspase-3 cleavage. We review our current understanding of pyroptosis as well as current knowledge of the gasdermin family.
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Cites
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
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Huang, Y., Xu, W., & Zhou, R. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00740-6 · Cited by 1,527
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
Evavold, C. L., Ruan, J., Tan, Y., Xia, S., Wu, H., & Kagan, J. C. (2018) · Immunity · doi:10.1016/j.immuni.2017.11.013 · Cited by 1,115
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Luo, Z., Tian, M., Yang, G., Tan, Q., Chen, Y., Li, G., Zhang, Q., Li, Y., Wan, P., & Wu, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01080-1 · Cited by 499
Current understanding of osteoarthritis pathogenesis and relevant new approaches
Tong, L., Yu, H., Huang, X., Shen, J., Xiao, G., Chen, L., Wang, H., Xing, L., & Chen, D. (2022) · Bone Research · doi:10.1038/s41413-022-00226-9 · Cited by 437
Metadata
- Authors
- Kovacs, S. B., & Miao, E. A.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 27
- Issue
- 9
- Pages
- 673-684
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2627048017
- Cited by
- 1,379
- References
- 74
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- green
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