Prediction of disease activity in models of multiple sclerosis by molecular magnetic resonance imaging of P-selectin
Open accessAbstract
Significance: Multiple sclerosis is a brain and spinal cord disease. In the most common forms, the disease unfolds by switching between periods of relapses, during which symptoms rise, and remissions, during which symptoms decline. However, it is not yet possible to predict the occurrence of relapses and remissions. Today, the diagnosis of multiple sclerosis is based on clinical criteria and on the use of magnetic resonance imaging (MRI). Here, we developed an MRI method that helps predict relapses and remissions in a classical model of multiple sclerosis in the mouse.
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In experimental autoimmune encephalomyelitis models, a key pathophysiological event is encephalitogenic leukocyte CNS infiltration across the blood-brain barrier via sequential steps of capture, rolling, activation, adhesion, crawling, and diapedesis in postcapillary venules, capillaries, and mid-capillaries.
“Experimental findings in MS models of chronic and relapsing EAE have shown that a key pathophysiological event is encephalitogenic leukocyte CNSinfiltration across the BBB that occurs via sequential steps of capture, rolling, activation, adhesion, crawling, and diapedesis in postcapillary venules, capillaries, and mid-capillaries (161, 182, 215, 216, 456, 617)”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [182]
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Experimental — accuracy not yet measuredIn experimental autoimmune encephalomyelitis mice, blood-spinal cord barrier disruption occurs following a caudo-rostral progression over time.
“A recent study also confirmed that BSCB disruption occurs following a caudo-rostral progression over time using both Evans blue dye injection and fibrin(ogen) immunostaining in EAE mice (182).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [182]
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Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion
Barkalow, F., Goodman, M., Gerritsen, M., & Mayadas, T. (1996) · Blood · doi:10.1182/blood.v88.12.4585.bloodjournal88124585 · Cited by 110 · see citing works
Montagne, A., Gauberti, M., Macrez, R., Jullienne, A., Briens, A., Raynaud, J.-S., Louin, G., Buisson, A., Haelewyn, B., Docagne, F., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.018 · Cited by 70 · see citing works
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
- Authors
- Fournier, A. P., Quenault, A., Martinez de Lizarrondo, S., Gauberti, M., Defer, G., Vivien, D., Docagne, F., & Macrez, R.
- Affiliations
- Inserm (FR)
- Normandie University, Unicaen, INSERM, Physiopathology and Imaging of Neurological Disorders, 14074 Caen, France;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-05-22
- Volume
- 114
- Issue
- 23
- Pages
- 6116-6121
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5468646
- OpenAlex
- W2618644874
- Cited by
- 54
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 11 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 2
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- multiple sclerosis, P-selectin, molecular MRI, disease activity prediction, experimental autoimmune encephalomyelitis, recurrence prediction, remission, myelopathy, endothelial adhesion molecules, disease surveillance
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Contrast Media, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Multiple Sclerosis, Recurrence, Spinal Cord, Disease Progression, P-Selectin, Mice
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