The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
Open accessAbstract
Significance: The cell is divided into compartments where specific biochemical functions are performed. These compartments can be delineated by membranes or through phase separation of proteins or protein and nucleic acids to form membraneless organelles. The latter situation occurs with an intrinsically disordered region of Ddx4, a major constituent of germ granules. The nature of the interior of membraneless organelles is poorly understood. Here, we use NMR to show that the intrinsically disordered Ddx4 region remains disordered and highly dynamic in the phase-separated state, while diffusing as slowly as a particle the size of a bacterial cell. Ddx4 molecules form a network of interactions on phase separation, providing an alternative environment to that found in membrane-encapsulated organelles.
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Cites
Lipari, G., & Szabo, A. (1982) · Journal of the American Chemical Society · doi:10.1021/ja00381a009 · Cited by 3,777
Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.017 · Cited by 2,012
Anderson, P., & Kedersha, N. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512082 · Cited by 984
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Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
Martin, E. W., Holehouse, A. S., Peran, I., Farag, M., Incicco, J. J., Bremer, A., Grace, C. R., Soranno, A., Pappu, R. V., & Mittag, T. (2020) · Science · doi:10.1126/science.aaw8653 · Cited by 1,147
Harmon, T. S., Holehouse, A. S., Rosen, M. K., & Pappu, R. V. (2017) · eLife · doi:10.7554/elife.30294 · Cited by 713
Relationship of sequence and phase separation in protein low-complexity regions
Martin, E. W., & Mittag, T. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00008 · Cited by 389
Abyzov, A., Blackledge, M., & Zweckstetter, M. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00774 · Cited by 215
Metadata
- Authors
- Brady, J. P., Farber, P. J., Sekhar, A., Lin, Y.-H., Huang, R., Bah, A., Nott, T. J., Chan, H. S., Baldwin, A. J., Forman-Kay, J. D., & Kay, L. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-09-11
- Volume
- 114
- Issue
- 39
- Pages
- E8194-E8203
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2755105920
- Cited by
- 533
- References
- 3
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
