BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

The amyloid hypothesis of Alzheimer's disease at 25 years

Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164 · see citing works

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · cited 1× · see citing works

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960 · see citing works

Alzheimer's disease

Masters, C. L., Bateman, R., Blennow, K., Rowe, C. C., Sperling, R. A., & Cummings, J. L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.56 · Cited by 1,853 · see citing works

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757 · see citing works

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., et al. (2012) · Nature · doi:10.1038/nature11283 · Cited by 1,738 · see citing works

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668 · see citing works

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease

Busche, M. A., Eichhoff, G., Adelsberger, H., Abramowski, D., Wiederhold, K.-H., Haass, C., Staufenbiel, M., Konnerth, A., & Garaschuk, O. (2008) · Science · doi:10.1126/science.1162844 · Cited by 1,125 · see citing works

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880 · see citing works

Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

Koffie, R. M., Meyer-Luehmann, M., Hashimoto, T., Adams, K. W., Mielke, M. L., Garcia-Alloza, M., Micheva, K. D., Smith, S. J., Kim, M. L., Lee, V. M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811698106 · Cited by 850 · see citing works

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780 · see citing works

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease

Busche, M. A., Chen, X., Henning, H. A., Reichwald, J., Staufenbiel, M., Sakmann, B., & Konnerth, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206171109 · Cited by 715 · see citing works

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

Musiek, E. S., & Holtzman, D. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4018 · Cited by 697 · see citing works

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

Mander, B. A., Marks, S. M., Vogel, J. W., Rao, V. R., Lu, B. S., Saletin, J., Ancoli‐Israel, S., Jagust, W. J., & Walker, M. P. (2015) · Nature Neuroscience · doi:10.1038/nn.4035 · Cited by 546 · see citing works

Astrocytes in physiological aging and Alzheimer’s disease

Rodríguez-Arellano, J. J., Parpura, V., Zorec, R., & Verkhratsky, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.007 · Cited by 439 · see citing works

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Willem, M., Tahirovic, S., Busche, M. A., Ovsepian, S. V., Chafai, M., Kootar, S., Hornburg, D., Evans, L. D. B., Moore, S., Daria, A., et al. (2015) · Nature · doi:10.1038/nature14864 · Cited by 398 · cited 1× · see citing works

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients

Kennedy, M., Stamford, A., Chen, X., Cox, K., Cumming, J., Dockendorf, M., Egan, M. F., Ereshefsky, L., Hodgson, R., Hyde, L., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9704 · Cited by 391 · see citing works

Impairments of neural circuit function in Alzheimer's disease

Busche, M. A., & Konnerth, A. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0429 · Cited by 360 · see citing works

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

Yang, T., Li, S., Xu, H., Walsh, D. M., & Selkoe, D. J. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1698-16.2016 · Cited by 347 · see citing works

Neuronal hyperactivity--A key defect in Alzheimer’s disease?

Busche, M. A., & Konnerth, A. (2015) · BioEssays · doi:10.1002/bies.201500004 · Cited by 266 · see citing works

Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice

Yan, P., Bero, A. W., Cirrito, J. R., Xiao, Q., Hu, X., Wang, Y., Gonzales, E., Holtzman, D. M., & Lee, J.-M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2637-09.2009 · Cited by 264 · see citing works

Hippocampal Hyperactivation Associated with Cortical Thinning in Alzheimer's Disease Signature Regions in Non-Demented Elderly Adults

Putcha, D., Brickhouse, M. J., O’Keefe, K., Sullivan, C., Rentz, D. M., Marshall, G. A., Dickerson, B. C., & Sperling, R. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4740-11.2011 · Cited by 258 · see citing works

Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo

Stroh, A., Adelsberger, H., Groh, A., Rühlmann, C., Fischer, S., Schierloh, A., Deisseroth, K. A., & Konnerth, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.031 · Cited by 249 · see citing works

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

Yamamoto, K., Tanei, Z., Hashimoto, T., Wakabayashi, T., Okuno, H., Naka, Y., Yizhar, O., Fenno, L. E., Fukayama, M., Bito, H., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.017 · Cited by 225 · see citing works

Rescue of long-range circuit dysfunction in Alzheimer's disease models

Busche, M. A., Kekuš, M., Adelsberger, H., Noda, T., Förstl, H., Nelken, I., & Konnerth, A. (2015) · Nature Neuroscience · doi:10.1038/nn.4137 · Cited by 215 · see citing works

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans

May, P. C., Willis, B. A., Lowe, S. L., Dean, R. A., Monk, S. A., Cocke, P. J., Audia, J. E., Boggs, L. N., Borders, A. R., Brier, R. A., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4129-14.2015 · Cited by 206 · see citing works

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Barão, S., Moechars, D., Lichtenthaler, S., & de Strooper, B. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.01.003 · Cited by 161 · see citing works

Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition

Das, P., Murphy, M. P., Younkin, L. H., Younkin, S. G., & Golde, T. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00245-7 · Cited by 150 · see citing works

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

Busche, M. A., Grienberger, C., Keskin, A. D., Song, B., Neumann, U., Staufenbiel, M., Förstl, H., & Konnerth, A. (2015) · Nature Neuroscience · doi:10.1038/nn.4163 · Cited by 141 · see citing works

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

Grienberger, C., Rochefort, N. L., Adelsberger, H., Henning, H. A., Hill, D. N., Reichwald, J., Staufenbiel, M., & Konnerth, A. (2012) · Nature Communications · doi:10.1038/ncomms1783 · Cited by 138 · see citing works

Neuropathology after active Aβ42 immunotherapy: implications for Alzheimer’s disease pathogenesis

Boche, D., Denham, N., Holmes, C., & Nicoll, J. A. R. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0719-5 · Cited by 135 · see citing works

Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion

Maier, F. C., Wehrl, H. F., Schmid, A. M., Mannheim, J. G., Wiehr, S., Lerdkrai, C., Calaminus, C., Stahlschmidt, A., Ye, L., Burnet, M. W. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3734 · Cited by 123 · see citing works

Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline

Leal, S. L., Landau, S. M., Bell, R. K., & Jagust, W. J. (2017) · eLife · doi:10.7554/elife.22978 · Cited by 117 · see citing works

Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity

Yuan, P., & Grutzendler, J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2531-15.2016 · Cited by 114 · see citing works

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.

Neumann, U., Rueeger, H., Machauer, R., Veenstra, S. J., Lueoend, R. M., Tintelnot-Blomley, M., Laue, G., Beltz, K., Vogg, B., Schmid, P., et al. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0033-8 · Cited by 113 · see citing works

Impairment of in vivo calcium signaling in amyloid plaque-associated microglia

Brawek, B., Schwendele, B., Riester, K., Kohsaka, S., Lerdkrai, C., Liang, Y., & Garaschuk, O. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1242-2 · Cited by 106 · see citing works

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

Shimshek, D. R., Jacobson, L. H., Kolly, C., Zamurovic, N., Balavenkatraman, K. K., Morawiec, L., Kreutzer, R., Schelle, J., Jucker, M., Bertschi, B., et al. (2016) · Scientific Reports · doi:10.1038/srep21917 · Cited by 69 · see citing works

In vivo calcium imaging of the aging and diseased brain

Eichhoff, G., Busche, M. A., & Garaschuk, O. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-007-0709-6 · Cited by 59 · see citing works

Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice

Mably, A. J., Liu, W., Donald, J. M. M., Dodart, J., Bard, F., Lemere, C. A., O’Nuallain, B., & Walsh, D. M. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.07.008 · Cited by 52 · see citing works

Imaging microcircuit function in healthy and diseased brain

Garaschuk, O. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.02.009 · Cited by 23 · see citing works

Component analysis reveals sharp tuning of the local field potential in the guinea pig auditory cortex

Alain De Cheveigné, A., Edeline, J., Gaucher, Q., & Gourévitch, B. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00040.2012 · Cited by 20 · see citing works

Alzheimer disease

Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606 · see citing works

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870 · see citing works

A vicious cycle of β amyloid−dependent neuronal hyperactivation

Zott, B., Simon, M. M., Hong, W., Unger, F., Chen-Engerer, H.-J., Frosch, M. P., Sakmann, B., Walsh, D. M., & Konnerth, A. (2019) · Science · doi:10.1126/science.aay0198 · Cited by 640 · see citing works

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

Busche, M. A., Wegmann, S., Dujardin, S., Commins, C., Schiantarelli, J., Klickstein, N., Kamath, T. V., Carlson, G. A., Nelken, I., & Hyman, B. T. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0289-8 · Cited by 413 · see citing works

BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

Moussa‐Pacha, N. M., Abdin, S. M., Omar, H. A., Alniss, H. Y., & Al‐Tel, T. H. (2019) · Medicinal Research Reviews · doi:10.1002/med.21622 · Cited by 308 · see citing works

Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

Maestú, F., de Haan, W., Busche, M. A., & DeFelipe, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101372 · Cited by 235 · see citing works

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Zott, B., Busche, M. A., Sperling, R. A., & Konnerth, A. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061725 · Cited by 215 · see citing works

Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease

Hijazi, S., Heistek, T. S., Scheltens, P., Neumann, U., Shimshek, D. R., Mansvelder, H. D., Smit, A. B., & van Kesteren, R. E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0483-4 · Cited by 216 · see citing works

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

Neumann, U., Ufer, M., Jacobson, L. H., Rouzade‐Dominguez, M., Huledal, G., Kolly, C., Lüönd, R. M., Machauer, R., Veenstra, S. J., Hurth, K., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809316 · Cited by 177 · see citing works

Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s Disease

Harris, S. S., Wolf, F., De Strooper, B., & Busche, M. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.005 · Cited by 161 · see citing works

Intracellular Ca 2+ stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer’s disease

Lerdkrai, C., Asavapanumas, N., Brawek, B., Kovalchuk, Y., Mojtahedi, N., Olmedillas, M., & Garaschuk, O. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714409115 · Cited by 137 · see citing works

Amyloid-β: a potential link between epilepsy and cognitive decline

Romoli, M., Sen, A., Parnetti, L., Calabresi, P., & Costa, C. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00505-9 · Cited by 132 · see citing works

Investigational BACE inhibitors for the treatment of Alzheimer’s disease

Imbimbo, B. P., & Watling, M. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1683160 · Cited by 132 · see citing works

Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S. S., Dey, P. N., Chen, C., Monteiro, O., et al. (2018) · eLife · doi:10.7554/elife.38744 · Cited by 117 · see citing works

Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer’s Disease

Toniolo, S., Sen, A., & Husain, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239318 · Cited by 94 · see citing works

Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease

Hector, A., & Brouillette, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.600084 · Cited by 90 · see citing works

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

Peters, F., Salihoglu, H., Rodrigues, E. F., Herzog, É., Blume, T., Filser, S., Dorostkar, M. M., Shimshek, D. R., Brose, N., Neumann, U., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1804-9 · Cited by 86 · see citing works

Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies

Zheng, Q., Kebede, M. T., Kemeh, M. M., Islam, S., Lee, B., Bleck, S. D., Wurfl, L. A., & Lazo, N. D. (2019) · Molecules · doi:10.3390/molecules24122316 · Cited by 81 · see citing works

Amyloid, APP, and Electrical Activity of the Brain

Hefter, D., Ludewig, S., Draguhn, A., & Körte, M. (2019) · The Neuroscientist · doi:10.1177/1073858419882619 · Cited by 76 · see citing works

Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus

Rodriguez, G. A., Barrett, G., Duff, K., & Hussaini, S. A. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000851 · Cited by 76 · see citing works

Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease

McDaid, J., Mustaly-Kalimi, S., & Stutzmann, G. E. (2020) · Cells · doi:10.3390/cells9122655 · Cited by 73 · see citing works

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1

Johnson, E. C. B., Ho, K., Yu, G.-Q., Das, M., Sanchez, P. E., Djukic, B., Lopez, I., Yu, X., Gill, M., Zhang, W., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00393-5 · Cited by 73 · see citing works

AdipoRon improves cognitive dysfunction of Alzheimer’s disease and rescues impaired neural stem cell proliferation through AdipoR1/AMPK pathway

Liu, B., Liu, J., Wang, J., Liu, C., & Yan, H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113249 · Cited by 67 · see citing works

Impairments of glutamatergic synaptic transmission in Alzheimer’s disease

Zott, B., & Konnerth, A. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.013 · Cited by 64 · see citing works

Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

Yao, J., Sun, B., Institóris, Á., Zhan, X., Guo, W., Song, Z., Liu, Y., Hiess, F., Boyce, A. K. J., Ni, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108169 · Cited by 65 · see citing works

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease

Rajani, R. M., Ellingford, R., Hellmuth, M., Harris, S. S., Taso, O. S., Graykowski, D., Lam, F. K. W., Arber, C., Fertan, E., Danial, J. S. H., et al. (2024) · PLOS Biology · doi:10.1371/journal.pbio.3002727 · Cited by 57 · see citing works

Cerebral hyperactivation across the Alzheimer’s disease pathological cascade

Corriveau‐Lecavalier, N., Adams, J. N., Fischer, L., Molloy, E. N., & Maaß, A. (2024) · Brain Communications · doi:10.1093/braincomms/fcae376 · Cited by 56 · see citing works

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Meier, S. R., Syvänen, S., Hultqvist, G., Fang, X. T., Roshanbin, S., Lannfelt, L., Neumann, U., & Sehlin, D. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.213140 · Cited by 51 · see citing works

Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice

Focke, C., Blume, T., Zott, B., Shi, Y., Deußing, M., Peters, F., Schmidt, C., Kleinberger, G., Lindner, S., Gildehaus, F., et al. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.217703 · Cited by 48 · see citing works

The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer’s disease

Fronza, M. G., Alves, D. A. C., Praticò, D., & Savegnago, L. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102033 · Cited by 47 · see citing works

Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

Hijazi, S., Heistek, T. S., van der Loo, R. J., Mansvelder, H. D., Smit, A. B., & van Kesteren, R. E. (2020) · iScience · doi:10.1016/j.isci.2020.101271 · Cited by 48 · see citing works

Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease

Wang, J., Liu, B., Xu, Y. X., Yang, M., Wang, C., Song, M., Liu, J., Wang, W., You, J., Sun, F., et al. (2021) · Aging Cell · doi:10.1111/acel.13333 · Cited by 46 · see citing works

Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease

Volloch, V., & Rits‐Volloch, S. (2018) · Medical Sciences · doi:10.3390/medsci6020045 · Cited by 42 · see citing works

11C-PiB and124I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention

Meier, S. R., Sehlin, D., Roshanbin, S., Falk, V. L., Saito, T., Saido, T. C., Neumann, U., Rokka, J., Eriksson, J., & Syvänen, S. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262083 · Cited by 39 · see citing works

Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review

Gehlot, P., Kumar, S., Vyas, V. K., Choudhary, B. S., Sharma, M., & Malik, R. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.117047 · Cited by 40 · see citing works

Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology

Jiang, X., Liu, W.-W., Wu, Y., Wu, Q., Lu, H., Xu, Z., Gao, H., & Zhao, Q.-C. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112433 · Cited by 37 · see citing works

Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials

Scheijbeler, E. P., de Haan, W., Stam, C. J., Twisk, J. W. R., & Gouw, A. A. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01327-1 · Cited by 37 · see citing works

A multi-scale model explains oscillatory slowing and neuronal hyperactivity in Alzheimer’s disease

Alexandersen, C. G., de Haan, W., Bick, C., & Goriely, A. (2023) · Journal of The Royal Society Interface · doi:10.1098/rsif.2022.0607 · Cited by 36 · see citing works

Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer’s Disease

Paolis, M. L. D., Paoletti, I., Zaccone, C., Capone, F., D’Amelio, M., & Krashia, P. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00423-y · Cited by 39 · see citing works

Mutual Interactions between Brain States and Alzheimer’s Disease Pathology: A Focus on Gamma and Slow Oscillations

Byron, N., Semenova, A., & Sakata, S. (2021) · Biology · doi:10.3390/biology10080707 · Cited by 31 · see citing works

Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer’s Disease

Wang, Z.-J., Zhao, F., Wang, C.-F., Zhang, X., Xiao, Y., Zhou, F., Wu, M., Zhang, J., Qi, J., & Yang, W. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190796 · Cited by 30 · see citing works

The β‐secretase (BACE) inhibitor NB‐360 in preclinical models: From amyloid‐β reduction to downstream disease‐relevant effects

Neumann, U., Machauer, R., & Shimshek, D. R. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14582 · Cited by 27 · see citing works

Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice

Tang, Y., Shao, S., Guo, Y., Zhou, Y., Cao, J., Xu, A., Wu, J., Li, Z., & Xiang, D. (2019) · Neural Plasticity · doi:10.1155/2019/2823679 · Cited by 28 · see citing works

Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis

Wang, J., Liu, B., Xu, Y. X., Luan, H., Wang, C., Yang, M., Zhao, R., Song, M., Liu, J., Sun, L., et al. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113870 · Cited by 26 · see citing works

Develop potential multi-target drugs by self-assembly of quercetin with amino acids and metal ion to achieve significant efficacy in anti-Alzheimer’s disease

Zhu, C., Yang, Y., Li, X., Chen, X., Lin, X., & Wu, X. (2022) · Nano Research · doi:10.1007/s12274-021-4066-8 · Cited by 26 · see citing works

The Amyloid Cascade Hypothesis 2.0 for Alzheimer’s Disease and Aging-Associated Cognitive Decline: From Molecular Basis to Effective Therapy

Volloch, V., & Rits‐Volloch, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512246 · Cited by 28 · see citing works

Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer’s Disease Model Mice

Takamura, R., Mizuta, K., Sekine, Y., Islam, T., Saito, T., Sato, M., Ohkura, M., Nakai, J., Ohshima, T., Saido, T. C., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0208-21.2021 · Cited by 24 · see citing works

β-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models of Alzheimer’s Disease

Zott, B., Nästle, L., Grienberger, C., Unger, F., Knauer, M., Wolf, C., Keskin, A. D., Feuerbach, A., Busche, M. A., Skerra, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50153-y · Cited by 22 · see citing works

Alzheimer’s Disease is Driven by Intraneuronally Retained Beta-Amyloid Produced in the AD-Specific, βAPP-Independent Pathway: Current Perspective and Experimental Models for Tomorrow

Volloch, V., Olsen, B. R., & Rits‐Volloch, S. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.02-1007 · Cited by 23 · see citing works

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

Pini, L., Lista, S., Griffa, A., Allali, G., & Imbimbo, B. P. (2024) · Brain Communications · doi:10.1093/braincomms/fcae460 · Cited by 21 · see citing works

Limiting RyR2 open time prevents Alzheimer's disease‐related deficits in the 3xTG‐AD mouse model

Liu, Y., Yao, J., Song, Z., Guo, W., Sun, B., Wei, J., Estillore, J. P., Back, T. G., & Chen, S. R. W. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24936 · Cited by 22 · see citing works

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo

Papanikolaou, A., Graykowski, D. R., Lee, B. I., Yang, M., Ellingford, R. A., Zünkler, J., Bond, S. A., Rowland, J. M., Rajani, R. M., Harris, S., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.04.010 · Cited by 22 · see citing works

β-Secretase BACE1 Is Required for Normal Cochlear Function

Dierich, M., Hartmann, S., Dietrich, N., Moeser, P., Brede, F. A., Chacko, L. J., Tziridis, K., Schilling, A., Krauß, P., Hessler, S., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0028-19.2019 · Cited by 21 · see citing works

Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation

Biechele, G., Blume, T., Deußing, M., Zott, B., Shi, Y., Xiang, X., Franzmeier, N., Kleinberger, G., Peters, F., Ochs, K., et al. (2021) · Theranostics · doi:10.7150/thno.64022 · Cited by 20 · see citing works

Failure in a population: Tauopathy disrupts homeostatic set-points in emergent dynamics despite stability in the constituent neurons

McGregor, J. N., Farris, C. A., Ensley, S., Schneider, A. M., Fosque, L. J., Wang, C., Tilden, E. I., Liu, Y., Tu, J., Elmore, H., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.08.006 · Cited by 23 · see citing works

AD “Statin”: Alzheimer’s Disorder is a “Fast” Disease Preventable by Therapeutic Intervention Initiated Even Late in Life and Reversible at the Early Stages

Volloch, V., Olsen, B. R., & Rits‐Volloch, S. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.02-1006 · Cited by 19 · see citing works

Early hippocampal hyperexcitability and synaptic reorganization in mouse models of amyloidosis

Ray, A., Loghinov, I., Ravindranath, V., & Barth, A. L. (2024) · iScience · doi:10.1016/j.isci.2024.110629 · Cited by 17 · see citing works

Protein-Encoding RNA to RNA Information Transfer in Mammalian Cells: RNA-dependent mRNA Amplification. Identification of Chimeric RNA Intermediates and Putative RNA End Products

Volloch, V., Rits‐Volloch, S., & Olsen, B. R. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.01-1003 · Cited by 18 · see citing works

β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses

Hartmann, S., Zheng, F., Kyncl, M. C., Karch, S., Voelkl, K., Zott, B., D’Avanzo, C., Lomoio, S., Tesco, G., Kim, D. Y., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2643-17.2018 · Cited by 17 · see citing works

Emerging links between cell competition and Alzheimer's disease

Coelho, D. S., & Moreno, E. (2019) · Journal of Cell Science · doi:10.1242/jcs.231258 · Cited by 17 · see citing works

Modelling the contributions to hyperexcitability in a mouse model of Alzheimer's disease

Mittag, M., Mediavilla, L., Remy, S., Cuntz, H., & Jedlička, P. (2023) · The Journal of Physiology · doi:10.1113/jp283401 · Cited by 19 · see citing works

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AβPP-β Cleavage Decreasing Amyloid-β Production and Accumulation in Alzheimer’s Disease Models

Resende, R., Ferreira-Marques, M., Moreira, P., Coimbra, J. R. M., Baptista, S. J., Isidoro, C., Salvador, J. A. R., Dinis, T., Pereira, C., & Santos, A. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200381 · Cited by 12 · see citing works

AdipoRon promotes amyloid‐β clearance through enhancing autophagy via nuclear GAPDH‐induced sirtuin 1 activation in Alzheimer's disease

Sun, F., Wang, J., Meng, L., Zhou, Z., Xu, Y., Yang, M., Li, Y., Jiang, T., Liu, B., & Yan, H. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16400 · Cited by 15 · see citing works

Protein-Encoding RNA-to-RNA Information Transfer in Mammalian Cells: Principles of RNA-Dependent mRNA Amplification

Volloch, V. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.01-1002 · Cited by 17 · see citing works

Precursor-Independent Overproduction of Beta-Amyloid in AD: Mitochondrial Dysfunction as Possible Initiator of Asymmetric RNA-Dependent βAPP mRNA Amplification. An Engine that Drives Alzheimer’s Disease

Volloch, V., Olsen, B. R., & Rits‐Volloch, S. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.01-1005 · Cited by 14 · see citing works

The Amyloid Cascade Hypothesis 2.0: On the Possibility of Once-in-a-Lifetime-Only Treatment for Prevention of Alzheimer’s Disease and for Its Potential Cure at Symptomatic Stages

Volloch, V., & Rits‐Volloch, S. (2022) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220031 · Cited by 14 · see citing works

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

Zhu, K., Wang, H., Ye, K., Chen, G., & Zhang, Z. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01573 · Cited by 13 · see citing works

Selective Regional Loss of Cortical Synapses Lacking Presynaptic Mitochondria in the 5xFAD Mouse Model

Seo, N., Kim, G. H., Noh, J. E., Shin, J. W., Lee, C. H., & Lee, K. J. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.690168 · Cited by 13 · see citing works

Verubecestat for Prodromal Alzheimer’s Disease

Li, S., Liu, L., & Selkoe, D. J. (2019) · New England Journal of Medicine · doi:10.1056/nejmc1906679 · Cited by 13 · see citing works

Next Generation Therapeutic Strategy for Treatment and Prevention of Alzheimer’s Disease and Aging-Associated Cognitive Decline: Transient, Once-in-a-Lifetime-Only Depletion of Intraneuronal Aβ (iAβ) by Its Targeted Degradation via Augmentation of Intra-iAβ-Cleaving Activities of BACE1 and/or BACE2

Volloch, V., & Rits‐Volloch, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417586 · Cited by 12 · see citing works

Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting

Sandoval, K. E., & WITT, K. A. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001117 · Cited by 14 · see citing works

Structural and functional remodeling of neural networks in β-amyloid driven hippocampal hyperactivity

Li, J., Liu, Y., Yin, C., Zeng, Y., & Mei, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102468 · Cited by 12 · see citing works

BACE1 as an early biomarker and its relevance to risk factors for Alzheimer’s disease

Ohno, M. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111475 · Cited by 12 · see citing works

Alzheimer’s Disease Prevention and Treatment: Case for Optimism

Volloch, V., Olsen, B. R., & Rits‐Volloch, S. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.02-1008 · Cited by 11 · see citing works

RyR2‐dependent modulation of neuronal hyperactivity: A potential therapeutic target for treating Alzheimer's disease

Yao, J., & Chen, S. R. W. (2023) · The Journal of Physiology · doi:10.1113/jp283824 · Cited by 10 · see citing works

Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition

Blume, T., Deussing, M., Biechele, G., Peters, F., Zott, B., Schmidt, C., Franzmeier, N., Wind, K., Eckenweber, F., Sacher, C., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.854031 · Cited by 10 · see citing works

News from Mars: Two-Tier Paradox, Intracellular PCR, Chimeric Junction Shift, Dark Matter mRNA and Other Remarkable Features of Mammalian RNA-Dependent mRNA Amplification. Implications for Alzheimer’s Disease, RNA-Based Vaccines and mRNA Therapeutics

Volloch, V., & Rits‐Volloch, S. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.02-1009 · Cited by 9 · see citing works

Genetically and pharmacologically limiting RyR2 open time prevents neuronal hyperactivity of hippocampal CA1 neurons in brain slices of 5xFAD mice

Sun, B., Yao, J., Chen, A. W., Estillore, J. P., Wang, R., Back, T. G., & Chen, S. R. W. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136011 · Cited by 9 · see citing works

β-secretase inhibition prevents structural spine plasticity deficits in AppNL-G-F mice

Blume, T., Filser, S., Sgobio, C., Peters, F., Neumann, U., Shimshek, D. R., Saito, T., Saido, T. C., Brendel, M., & Herms, J. W. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.909586 · Cited by 9 · see citing works

On the Inadequacy of the Current Transgenic Animal Models of Alzheimer’s Disease: The Path Forward

Volloch, V., & Rits‐Volloch, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052981 · Cited by 8 · see citing works

A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity

Bonifazi, G., Luchena, C., Gaminde‐Blasco, A., Ortiz-Sanz, C., Capetillo‐Zarate, E., Matute, C., Alberdi, E. M., & Pittà, M. D. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106473 · Cited by 9 · see citing works

Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties

Sun, D., Chen, C., Moschke, K., Huang, J., & Fang, W. (2019) · Molecules · doi:10.3390/molecules25010102 · Cited by 8 · see citing works

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Harris, S., Rajani, R. M., Zünkler, J., Ellingford, R. A., Yang, M., Rowland, J. M., Schmidt, A., Lee, B. I., Kehring, M., Hellmuth, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115801 · Cited by 7 · see citing works

Excitation–inhibition imbalance as a common thread linking early Alzheimer's disease with temporal lobe epilepsy

Okechukwu, N. G., Zaccone, C., Barbera, L. L., Nobili, A., & D’Amelio, M. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115581 · Cited by 7 · see citing works

R-carvedilol, a potential new therapy for Alzheimer’s disease

Yao, J., & Chen, S. R. W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1062495 · Cited by 7 · see citing works

Capturing Amyloid-β Oligomers by Stirring with Microscaled Iron Oxide Stir Bars into Magnetic Plaques to Reduce Cytotoxicity toward Neuronal Cells

Tsai, Y.-C., Luo, J.-C., Liu, T., Lu, I.-L., Shen, M., Chuang, C., Chern, C., & Chiu, H. (2020) · Nanomaterials · doi:10.3390/nano10071284 · Cited by 6 · see citing works

Alzheimer’s Disease is Driven by Beta-Amyloid Generated in the Amyloid Precursor Protein-Independent Pathway and Retained Intraneuronally: Research and Therapeutic Strategies in a New AD Paradigm

Volloch, V., & Rits‐Volloch, S. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.-v2-id1010 · Cited by 6 · see citing works

Biomarker evidence of early vision and rod energy-linked pathophysiology benefits from very low dose DMSO in 5xFAD mice

Berkowitz, B. A., Paruchuri, A., Stanek, J., Abdul-Nabi, M., Podolsky, R. H., Bustos, A. H., Childers, K. L., Murphy, G. G., Stangis, K. A., & Roberts, R. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01799-8 · Cited by 5 · see citing works

ACH2.0/E, the Consolidated Theory of Conventional and Unconventional Alzheimer’s Disease: Origins, Progression, and Therapeutic Strategies

Volloch, V., & Rits‐Volloch, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116036 · Cited by 5 · see citing works

Amyloid Beta Dynamics in Biological Fluids—Therapeutic Impact

Schreiner, T. G., & Popescu, B. O. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245986 · Cited by 5 · see citing works

A Strategy for Allowing Earlier Diagnosis and Rigorous Evaluation of BACE1 Inhibitors in Preclinical Alzheimer’s Disease

Ohno, M. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231451 · Cited by 5 · see citing works

The Reciprocal Interaction Between Sleep and Alzheimer’s Disease

Harris, S., Schwerd-Kleine, T., Lee, B. I., & Busche, M. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-81147-1_10 · Cited by 5 · see citing works

Neuroprotection in Alzheimer Disease

Jain, K. K. (2019) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-1-4939-9465-6_8 · Cited by 5 · see citing works

Alzheimer’s disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits

Ellingford, R. A., Harris, S., Kehring, M., Rajani, R. M., Lam, F. K. W., Graykowski, D. R., Böken, D., Welikovitch, L. A., Khasnavis, A., Laban, R., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.02.027 · Cited by 6 · see citing works

The intracerebral injection of Aβ1-42 oligomers does not invariably alter seizure susceptibility in mice

Vyver, M. V., Daeninck, L., Smet, G. D., Aourz, N., Sahu, S., Engelborghs, S., Pauwels, K., Bundel, D. D., & Smolders, I. J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1239140 · Cited by 4 · see citing works

Evaluating the Diagnostic Value of Electrovestibulography (EVestG) in Alzheimer’s Patients with Mixed Pathology: A Pilot Study

Dastgheib, Z. A., Lithgow, B., & Moussavi, Z. (2023) · Medicina · doi:10.3390/medicina59122091 · Cited by 4 · see citing works

Microbial Trojan Horses: Virulence Factors as Key Players in Neurodegenerative Diseases

Grahl, M. V. C., Hohl, K. S., Smaniotto, T. Â., & Carlini, C. R. (2025) · Molecules · doi:10.3390/molecules30030687 · Cited by 4 · see citing works

Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium

Lin, R., Sims, S. L., Wright, N. A., Galopin, L. B., Weiss, B. E., Kraner, S. D., Rhinehart, J. E., Lu, T., Sompol, P. M., Norris, C. M., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70564 · Cited by 4 · see citing works

Chronic BACE-1 Inhibitor Administration in TASTPM Mice (APP KM670/671NL and PSEN1 M146V Mutation): An EEG Study

Lopez, S., Percio, C. D., Forloni, G., Frasca, A., Drinkenburg, W. H. I. M., Lizio, R., Noce, G., Ferri, R., Soricelli, A., Stocchi, F., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239072 · Cited by 4 · see citing works

BACE inhibition-dependent repair of Alzheimer’s disease pathophysiology

Keskin, A. D., Konnerth, A., & München, T. U. (2021)

Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease

Devi, L., & Ohno, M. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.59 · Cited by 38 · see citing works

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice

Kimura, R., Devi, L., & Ohno, M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06608.x · Cited by 139 · see citing works

Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s disease

Yan, R., Fan, Q., Zhou, J., & Vassar, R. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.025 · Cited by 71 · see citing works

BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

Ohno, M., Sametsky, E. A., Younkin, L. H., Oakley, H., Younkin, S. G., Citron, M., Vassar, R., & Disterhoft, J. F. (2004) · Neuron · doi:10.1016/s0896-6273(03)00810-9 · Cited by 549 · see citing works