The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging
Open accessAbstract
Significance: Antibiotic resistance is a global threat to human health. The problem is aggravated by unnecessary and incorrect use of broad spectrum antibiotics. One way to provide correct treatment and slow down the development of antibiotic resistance is to assay the susceptibility profile of the infecting bacteria before treatment is initiated and let this information guide the choice of antibiotic. Here, we present an antibiotic susceptibility test that is sufficiently fast to be used at the point of care. We show that it is possible to determine if a urinary tract infection is caused by resistant bacteria within 30 min of loading a urine sample, even if the bacterial concentration in the urine is very low.
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Cites
Robust single-particle tracking in live-cell time-lapse sequences
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Urinary Tract Infections: Disease Panorama and Challenges
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Fast radial symmetry for detecting points of interest
Loy, G., & Zelinsky, A. (2003) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2003.1217601 · Cited by 593
The Diagnosis of Urinary Tract Infection
Schmiemann, G., Kniehl, E., Gebhardt, K., Matejczyk, M. M., & Hummers-Pradier, E. (2010) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2010.0361 · Cited by 440
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The Synchronization of Replication and Division Cycles in Individual E. coli Cells
Wallden, M., Fange, D., Lundius, E. G., Baltekin, Ö., & Elf, J. (2016) · Cell · doi:10.1016/j.cell.2016.06.052 · Cited by 331
Self-citationInterplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness
Marcusson, L. L., Frimodt-Møller, N., & Hughes, D. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000541 · Cited by 320
A rapid antimicrobial susceptibility test based on single-cell morphological analysis
Choi, J., Yoo, J., Lee, M., Kim, E.-G., Lee, J. S., Lee, S., Joo, S., Song, S. H., Kim, E.-C., Lee, J. C., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009650 · Cited by 311
Cited by
Sequencing-based methods and resources to study antimicrobial resistance
Boolchandani, M., D’Souza, A. W., & Dantas, G. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0108-4 · Cited by 522
Mechanisms and clinical relevance of bacterial heteroresistance
Andersson, D. I., Nicoloff, H., & Hjort, K. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0218-1 · Cited by 513
Self-citationCurrent and Emerging Methods of Antibiotic Susceptibility Testing
Khan, Z. A., Siddiqui, M. F., & Park, S. (2019) · Diagnostics · doi:10.3390/diagnostics9020049 · Cited by 442
Innovative and rapid antimicrobial susceptibility testing systems
van Belkum, A., Burnham, C.-A. D., Rossen, J. W. A., Mallard, F., Rochas, O., & Dunne, W. M. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0327-x · Cited by 355
Antibiotic resistance: turning evolutionary principles into clinical reality
Andersson, D. I., Balaban, N. Q., Baquero, F., Courvalin, P., Glaser, P., Gophna, U., Kishony, R., Molin, S., & Tønjum, T. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa001 · Cited by 238
Self-citation
Metadata
- Authors
- Baltekin, Ö., Boucharin, A., Tano, E., Andersson, D. I., & Elf, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-08-08
- Volume
- 114
- Issue
- 34
- Pages
- 9170-9175
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2744332922
- Cited by
- 417
- References
- 21
- FWCI
- 24.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Baltekin, Ö., Boucharin, A., Tano, E., Andersson, D. I., & Elf, J. (2017). Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1708558114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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