Antibiotic resistance: turning evolutionary principles into clinical reality
Open accessAbstract
Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The past few decades have witnessed rapid progress in our understanding of the multiple factors that affect the emergence and spread of antibiotic resistance at the population level and the level of the individual patient. However, the process of translating this progress into health policy and clinical practice has been slow. Here, we attempt to consolidate current knowledge about the evolution and ecology of antibiotic resistance into a roadmap for future research as well as clinical and environmental control of antibiotic resistance. At the population level, we examine emergence, transmission and dissemination of antibiotic resistance, and at the patient level, we examine adaptation involving bacterial physiology and host resilience. Finally, we describe new approaches and technologies for improving diagnosis and treatment and minimizing the spread of resistance.
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For immunocompromised cancer patients, multidrug-resistant infections can be life-threatening, with limited treatment options, prolonged hospital stays, and delayed or interrupted cancer therapy.
“For immunocompromised cancer patients, MDR infections can be life-threatening, with limited treatment options, prolonged hospital stays, and delayed or interrupted cancer therapy [126]”
From Phage therapy in oncology: opportunities for cancer prevention and treatment (2026) · cites this paper as [126]
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- Authors
- Andersson, D. I., Balaban, N. Q., Baquero, F., Courvalin, P., Glaser, P., Gophna, U., Kishony, R., Molin, S., & Tønjum, T.
- Affiliations
- Uppsala University (SE)
- Hebrew University of Jerusalem (IL)
- Department of Microbiology, Ramón y Cajal Health Research Institute, Ctra. Colmenar Viejo Km 9,100 28034 – Madrid, Madrid, Spain
- Institut Pasteur (FR)
- Tel Aviv University (IL)
- Technion – Israel Institute of Technology (IL)
- Novo Nordisk Foundation (DK)
- Oslo University Hospital (NO)
- Corresponding author
- Gophna, Uri
- ORCID
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-01-25
- Volume
- 44
- Issue
- 2
- Pages
- 171-188
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W3002094434
- Cited by
- 238
- References
- 5
- Citations by year
- 2026: 21 · 2025: 30 · 2024: 38 · 2023: 41 · 2022: 48 · 2021: 40 · 2020: 20
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- green
- urn.nb.no
- Licence
- Locations
- FEMS Microbiology Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Funders
- European Academy of Microbiology
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- antibiotic resistance, antibiotic resistance evolution, emergence of resistance, bacterial physiology, host resilience, resistance diagnosis, health policy
- MeSH terms
- Animals, Bacterial Infections, Humans, Preventive Medicine, Bacterial Physiological Phenomena, Evolution, Molecular, Drug Resistance, Bacterial
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