The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics
Open accessAbstract
Significance: The human placenta is a dynamic and cellular heterogeneous organ, which is critical in fetomaternal homeostasis and the development of preeclampsia. Previous work has shown that placenta-derived cell-free RNA increases during pregnancy. We applied large-scale microfluidic single-cell transcriptomic technology to comprehensively characterize cellular heterogeneity of the human placentas and identified multiple placental cell-type–specific gene signatures. Analysis of the cellular signature expression in maternal plasma enabled noninvasive delineation of the cellular dynamics of the placenta during pregnancy and the elucidation of extravillous trophoblastic dysfunction in early preeclampsia.
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
STAR: ultrafast universal RNA-seq aligner
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Massively parallel digital transcriptional profiling of single cells
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Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
Klein, A. M., Mazutis, L., Akartuna, I., Tallapragada, N., Veres, A., Li, V., Peshkin, L., Weitz, D. A., & Kirschner, M. W. (2015) · Cell · doi:10.1016/j.cell.2015.04.044 · Cited by 3,356
Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation
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Self-citationUsing ultrasound in the clinical management of placental implantation abnormalities
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Cited by
Single-cell reconstruction of the early maternal–fetal interface in humans
Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358
Construction of a human cell landscape at single-cell level
Han, X., Zhou, Z., Fei, L., Sun, H., Wang, R., Chen, Y., Chen, H., Wang, J., Tang, H., Ge, W., et al. (2020) · Nature · doi:10.1038/s41586-020-2157-4 · Cited by 1,087
Ambient black carbon particles reach the fetal side of human placenta
Bové, H., Bongaerts, E., Slenders, E., Bijnens, E. M., Saenen, N. D., Gyselaers, W., Van Eyken, P., Plusquin, M., Roeffaers, M. B. J., Ameloot, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11654-3 · Cited by 709
Single-Cell Transcriptomics Meets Lineage Tracing
Kester, L., & van Oudenaarden, A. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.04.014 · Cited by 375
Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution
Cheng, J. B., Sedgewick, A. J., Finnegan, A. I., Harirchian, P., Lee, J., Kwon, S., Fassett, M. S., Golovato, J., Gray, M., Ghadially, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.006 · Cited by 284
Metadata
- Authors
- Tsang, J. C. H., Vong, J. S. L., Ji, L., Poon, L. C. Y., Jiang, P., Lui, K. O., Ni, Y.-B., To, K. F., Cheng, Y. K. Y., Chiu, R. W. K., & Lo, Y. M. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-08-22
- Volume
- 114
- Issue
- 37
- Pages
- E7786-E7795
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2749281307
- Cited by
- 328
- References
- 8
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Tsang, J. C. H., Vong, J. S. L., Ji, L., Poon, L. C. Y., Jiang, P., Lui, K. O., Ni, Y.-B., To, K. F., Cheng, Y. K. Y., Chiu, R. W. K., & Lo, Y. M. D. (2017). Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1710470114
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