Cited by 233Nerve injury and regenerationPhagocytosis and Immune RegulationAutophagy in Disease and Therapy

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Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

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Brosius Lutz, Amanda, Chung, Won-Suk, Sloan, Steven A., Carson, Glenn A., Zhou, Lu, Lovelett, Emilie, Posada, Sean, Zuchero, J. Bradley, Barres, Ben A.·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1710566114PMC PMC5617301

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Abstract

Significance: Myelin is a potent inhibitor of axon regeneration. In the central nervous system, failure to clear myelin debris after injury presents a major roadblock to recovery. In contrast, rapid myelin clearance in the peripheral nervous system (PNS) contributes to this system’s remarkable regenerative capacity, but the mechanisms involved have remained incompletely understood. In this work, we set out to identify novel mechanisms of PNS myelin clearance to generate new ideas about activating myelin clearance in the injured CNS. We provide evidence that Schwann cells, myelinating glia of the PNS, engulf myelin debris using two receptors, Axl and Mertk. We hypothesize that astrocytes have the potential to use this same mechanism to engulf myelin debris after CNS injury.

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Authors: Brosius Lutz, A., Chung, W.-S., Sloan, S. A., Carson, G. A., Zhou, L., Lovelett, E., Posada, S., Zuchero, J. B., & Barres, B. A.
Affiliations: Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5125;
Korea Advanced Institute of Science and Technology (KR)
Stanford Medicine (US)
ORCID: Chung, Won-Suk
Sloan, Steven A.
Zhou, Lu
Zuchero, J. Bradley
Barres, Ben A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-09-05
Volume: 114
Issue: 38
Pages: E8072-E8080
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1710566114
PMC: PMC5617301
OpenAlex: W2752650605
Cited by: 225
References: 41
Citations by year: 2026: 20 · 2025: 20 · 2024: 23 · 2023: 27 · 2022: 30 · 2021: 35 · 2020: 29 · 2019: 22 · 2018: 19
FWCI: 9.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (none)
Christopher and Dana Reeve Foundation (none)
HHS | National Institutes of Health (EY11310, NIH NS069375, NIH 1S10RR02678001, NIH S10 Shared Instrument Grant S10RR027431-01)
Stanford Medical Scientist Training Program (none)
Developmental and Neonatal Biology Training Program (NIH T32 HD007249)
National Multiple Sclerosis Society (none)
National Research Foundation of Korea (NRF-2016M3C7A1905391, NRF-2016R1C1B3006969)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: Schwann cells, myelin debris clearance, TAM receptors, AXL, MERTK, phagocytosis, autophagy, peripheral nerve injury, nerve crush injury, macrophages, central nervous system regeneration, astrocytes, myelin debris
MeSH terms: c-Mer Tyrosine Kinase, Axl Receptor Tyrosine Kinase, Animals, Autophagy, Disease Models, Animal, Myelin Sheath, Phagocytosis, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, Mice, Peripheral Nerve Injuries

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Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

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