The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Reducing resistance allele formation in CRISPR gene drive
Open accessAbstract
Significance: A functioning gene drive mechanism could fundamentally change our strategies for the control of vector-borne diseases, such as malaria, dengue, and Zika. CRISPR homing gene drive promises such a mechanism, which could be used to rapidly spread genetic modifications among the mosquitoes that transmit these diseases. However, recent studies have shown that current drives would likely be unable to spread in insect populations due to the high rate at which resistance will evolve. In this study, we provide an experimental demonstration that guide RNA multiplexing can successfully reduce resistance rates but also find that such an approach would still need to be combined with additional strategies to create drives that are efficient enough for use in wild populations.
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Cites
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Kleinstiver, B. P., Pattanayak, V., Prew, M. S., Tsai, S. Q., Nguyen, N. T., Zheng, Z., & Joung, J. K. (2016) · Nature · doi:10.1038/nature16526 · Cited by 2,673
Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila
Port, F., Chen, H.-M., Lee, T., & Bullock, S. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405500111 · Cited by 1,046
Cited by
Fungicide resistance management: Maximizing the effective life of plant protection products
Corkley, I., Fraaije, B., & Hawkins, N. (2022) · Plant Pathology · doi:10.1111/ppa.13467 · Cited by 280
Metadata
- Authors
- Champer, J., Liu, J., Oh, S. Y., Reeves, R., Luthra, A., Oakes, N., Clark, A. G., & Messer, P. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-05-07
- Volume
- 115
- Issue
- 21
- Pages
- 5522-5527
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2950208551
- Cited by
- 274
- References
- 2
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Champer, J., Liu, J., Oh, S. Y., Reeves, R., Luthra, A., Oakes, N., Clark, A. G., & Messer, P. W. (2018). Reducing resistance allele formation in CRISPR gene drive. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1720354115
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