The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality
Open accessAbstract
Significance: This contribution reports on the application of gold nanorods to the detection of amyloids in Parkinson’s and prion diseases. We found that gold nanorods show no interaction with monomeric proteins but adsorb onto helical protein fibrils. Chiral amyloid templates induce helical arrangement of nanorods, giving rise to intense optical activity at the plasmon resonance wavelengths. This report shows the use of protein fibrils as templates for chiral nanoparticle assembly and development of a biodetection technique. We show this effect on a model recombinant protein, α-synuclein (involved in Parkinson’s disease), using CD, cryogenic transmission EM tomography, and theoretical simulations supporting the experimental findings. We additionally show application to identify patients with Parkinson’s disease from human brain homogenates.
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Citations
Cites
Protein aggregation and neurodegenerative disease
Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454
The amyloid state and its association with protein misfolding diseases.
Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3810 · Cited by 2,382
Biological metals and metal-targeting compounds in major neurodegenerative diseases
Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497
Roeters, S. J., Iyer, A., Pletikapić, G., Kogan, V., Subramaniam, V., & Woutersen, S. (2017) · Scientific Reports · doi:10.1038/srep41051 · Cited by 146
Metadata
- Authors
- Kumar, J., Eraña, H., López-Martínez, E., Claes, N., Martín, V. F., Solís, D. M., Bals, S., Cortajarena, A. L., Castilla, J., & Liz-Marzán, L. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-03-12
- Volume
- 115
- Issue
- 13
- Pages
- 3225-3230
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2792699430
- Cited by
- 312
- References
- 4
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
