The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
Open accessAbstract
Significance: Mechanical forces are important for normal gastrointestinal tract function. The enterochromaffin cells in the gastrointestinal epithelium have been proposed, but not previously shown, to be specialized sensors that convert forces into serotonin release, and serotonin released from these cells is important for normal gastrointestinal secretion and motility. The findings in this study show that some enterochromaffin cells are indeed mechanosensitive, and that they use mechanosensitive Piezo2 channels to generate an ionic current that is critical for the intracellular Ca 2+increase, serotonin release, and epithelial fluid secretion.
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Cites
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
A single-cell survey of the small intestinal epithelium
Haber, A. L., Biton, M., Rogel, N., Herbst, R. H., Shekhar, K., Smillie, C., Burgin, G., Delorey, T. M., Howitt, M. R., Katz, Y., et al. (2017) · Nature · doi:10.1038/nature24489 · Cited by 1,750
Single-cell messenger RNA sequencing reveals rare intestinal cell types
Grün, D., Lyubimova, A., Kester, L., Wiebrands, K., Basak, O., Sasaki, N., Clevers, H., & van Oudenaarden, A. (2015) · Nature · doi:10.1038/nature14966 · Cited by 1,234
Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
Bellono, N. W., Bayrer, J. R., Leitch, D. B., Castro, J., Zhang, C., O’Donnell, T. A., Brierley, S. M., Ingraham, H. A., & Julius, D. (2017) · Cell · doi:10.1016/j.cell.2017.05.034 · Cited by 910
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
Bae, C., Sachs, F., & Gottlieb, P. A. (2011) · Biochemistry · doi:10.1021/bi200770q · Cited by 566
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
Nozawa, K., Kawabata-Shoda, E., Doihara, H., Kojima, R., Okada, H., Mochizuki, S., Sano, Y., Inamura, K., Matsushime, H., Koizumi, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805323106 · Cited by 399
Costorage of enteroendocrine hormones evaluated at the cell and subcellular levels in male mice
Fothergill, L. J., Callaghan, B., Hunne, B., Bravo, D. M., & Furness, J. B. (2017) · Endocrinology · doi:10.1210/en.2017-00243 · Cited by 63
Cited by
Intestinal epithelial cells: At the interface of the microbiota and mucosal immunity
Soderholm, A. T., & Pedicord, V. A. (2019) · Immunology · doi:10.1111/imm.13117 · Cited by 281
Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction
Kaelberer, M. M., Rupprecht, L. E., Liu, W. W., Weng, P., & Bohórquez, D. V. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091619-022657 · Cited by 236
“The receptor that senses mechanical stimuli is Piezo2 (Wang et al. 2017), and genetic ablation of Piezo2 impairs the mechanosensitivity of enterochromaffin cells (Alcaino et al. 2018).”
BackgroundIntegrative neurocircuits that control metabolism and food intake
Brüning, J. C., & Fenselau, H. (2023) · Science · doi:10.1126/science.abl7398 · Cited by 214
Peterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160
Drobny, A., Ngo, P. A., Neurath, M. F., Zunke, F., & López-Posadas, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655123 · Cited by 24
Metadata
- Authors
- Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G., & Beyder, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-07-23
- Volume
- 115
- Issue
- 32
- Pages
- E7632-E7641
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2883884554
- Cited by
- 266
- References
- 7
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. https://app.cochat.ai/papers/10.1073/pnas.1804938115
- The paper
- Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G., & Beyder, A. (2018). A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1804938115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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