TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132 · see citing works

ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494 · see citing works

A TRP Channel that Senses Cold Stimuli and Menthol

Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361 · see citing works

TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents

Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,921 · see citing works

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Jordt, S., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. J. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,896 · see citing works

Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin

Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,822 · see citing works

The serotonin signaling system: from basic understanding to drug development for functional GI disorders

Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563 · see citing works

TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction

Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267 · see citing works

Pungent products from garlic activate the sensory ion channel TRPA1

Bautista, D. M., Movahed, P., Hinman, A., Axelsson, H. E., Sterner, O., Högestätt, E. D., Julius, D. J., Jordt, S., & Zygmunt, P. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505356102 · Cited by 863 · see citing works

Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing

Nagata, K., Duggan, A., Kumar, G., & Garcı́a-Añoveros, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0013-05.2005 · Cited by 646 · see citing works

The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin

Macpherson, L. J., Geierstanger, B. H., Viswanath, V., Bandell, M., Eid, S. R., Hwang, S. W., & Patapoutian, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.018 · Cited by 613 · see citing works

Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats

Fukumoto, S., Tatewaki, M., Yamada, T., Fujimiya, M., Mantyh, C., Voss, M., Eubanks, S., Harris, M., Pappas, T. N., & Takahashi, T. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00442.2002 · Cited by 465 · see citing works

An Ankyrin-like Protein with Transmembrane Domains Is Specifically Lost after Oncogenic Transformation of Human Fibroblasts

Jaquemar, D., Schenker, T., & Trüeb, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7325 · Cited by 333 · see citing works

The “Normal” Endocrine Cell of the Gut: Changing Concepts and New Evidences

Rindi, G., Leiter, A. B., Kopin, A. S., Bordi, C., & Solcia, E. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1294.001 · Cited by 296 · see citing works

5-HT3 Receptor Antagonists for the Prevention of Chemotherapy-Induced Nausea and Vomiting

Gregory, R. E., & Ettinger, D. S. (1998) · Drugs · doi:10.2165/00003495-199855020-00002 · Cited by 266 · see citing works

Enterochromaffin Cells of the Human Gut: Sensors for Spices and Odorants

Braun, T., Voland, P., Kunz, L., Prinz, C., & Gratzl, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.036 · Cited by 264 · see citing works

Neurohumoral control of gastrointestinal motility

Hansen, M. (2003) · Physiological Research · doi:10.33549/physiolres.930255 · Cited by 246 · see citing works

Pancreatic Endocrine Tumors

Klöppel, G., & Heitz, P. U. (1988) · Pathology - Research and Practice · doi:10.1016/s0344-0338(88)80043-8 · Cited by 244 · see citing works

Regulation of 5-HT release from enterochromaffin cells

Racké, K., Reimann, A., Schwörer, H., & Kilbinger, H. J. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00075-7 · Cited by 230 · see citing works

Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing

Berthoud, H., Kressel, M., Raybould, H., & Neuhuber, W. (1995) · Anatomy and Embryology · doi:10.1007/bf00187819 · Cited by 216 · see citing works

Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine

Foxx-Orenstein, A., Jf, K., & Grider, J. R. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8898642 · Cited by 190 · see citing works

Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.

Brock, N., Stekar, J., Pohl, J., Niemeyer, U., & Scheffler, G. (1979) · PubMed · Cited by 187 · see citing works

D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells

Kim, M., Cooke, H. J., Javed, N., Carey, H. V., Christofi, F. L., & Raybould, H. E. (2001) · Gastroenterology · doi:10.1053/gast.2001.29567 · Cited by 120 · see citing works

TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD

Stokes, A. J., Wakano, C., Koblan‐Huberson, M., Adra, C. N., Fleig, A., & Turner, H. C. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.12.009 · Cited by 116 · see citing works

Transient receptor potential A1 mediates an osmotically activated ion channel

Zhang, X., Chen, J., Faltynek, C. R., Moreland, R. B., & Neelands, T. R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06030.x · Cited by 112 · see citing works

Plasticity in serotonin control mechanisms in the gut

Gershon, M. D. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.07.005 · Cited by 111 · see citing works

Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder

de Andrade, E. L., Ferreira, J., Andrè, E., & Calixto, J. Β. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.003 · Cited by 106 · see citing works

Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine

Penuelas, A., Tashima, K., Tsuchiya, S., Matsumoto, K., Nakamura, T., Horie, S., & Yano, S. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.08.015 · Cited by 95 · see citing works

Mechanical stimulation activates Gαq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells

Kim, M., Javed, N., Yu, J., Christofi, F. L., & Cooke, H. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12467 · Cited by 89 · see citing works

Luminal sensing in the gut: an overview.

Dockray, G. (2003) · PubMed · Cited by 87 · see citing works

Insulin, Glucagon, and Somatostatin Receptors on Cultured Cells and Clones from Rat Islet Cell Tumor

Bhathena, S. J., Oie, H. K., Gazdar, A. F., Voyles, N. R., Wilkins, S. D., & Recant, L. (1982) · Diabetes · doi:10.2337/diab.31.6.521 · Cited by 84 · see citing works

Stroking human jejunal mucosa induces 5-HT release and Cl− secretion via afferent neurons and 5-HT4receptors

Kellum, J. M., Albuquerque, F. C., Stoner, M. C., & Harris, R. P. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.3.g515 · Cited by 84 · see citing works

Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine

Rindi, G., Ratineau, C., Ronco, A., Candusso, M. E., Tsai, M., & Leiter, A. B. (1999) · Development · doi:10.1242/dev.126.18.4149 · Cited by 83 · see citing works

Block by Ruthenium Red of Cloned Neuronal Voltage-Gated Calcium Channels

Cibulsky, S. M., & Sather, W. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38291-6 · Cited by 76 · see citing works

REVIEW: Small Bowel Review: Normal Physiology Part 1

Thomson, A. B. R., Keelan, M., Thiesen, A., Clandinin, M. T., Ropeleski, M. J., & Wild, G. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1012794505897 · Cited by 75 · see citing works

Evidence for a 5‐HT 3 receptor involvement in the facilitation of peristalsis on mucosal application of 5‐HT in the guinea pig isolated ileum

Tuladhar, B. R., Kaisar, M. E., & Naylor, R. J. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701503 · Cited by 59 · see citing works

Effects of serotonin on intestinal secretion and motility

Spiller, R. E. (2001) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200103000-00001 · Cited by 57 · see citing works

An examination of the 5‐HT3 receptor mediating contraction and evoked [3H]‐acetylcholine release in the guinea‐pig ileum

Fox, A. J., & Morton, I. K. M. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14119.x · Cited by 51 · see citing works

Isolation and receptor profiling of ileal enterochromaffin cells

Schäfermeyer, A., Gratzl, M., Rad, R. G., Dossumbekova, A., Sachs, G. M., & Prinz, C. (2004) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01299.x · Cited by 47 · see citing works

The Neuroendocrine System of the Gastrointestinal Tract

Heitz, P. U. (1979) · Pathology - Research and Practice · doi:10.1016/s0344-0338(79)80028-x · Cited by 40 · see citing works

REVIEW: Small Bowel Review: Normal Physiology Part 2

Thomson, A. B. R., Keelan, M., Thiesen, A., Clandinin, M. T., Ropeleski, M. J., & Wild, G. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1012746622735 · Cited by 36 · see citing works

Evidence for two types of 5-hydroxytryptamine receptor on secretomotor neurons of the guinea-pig ileum

Hendriks, R., Bornstein, J. C., & Furness, J. B. (1989) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00736055 · Cited by 31 · see citing works

Characterization of YM060, a potent and selective 5-hydroxytryptamine3 receptor antagonist, in rabbit nodose ganglion and N1E-115 neuroblastoma cells.

Ito, H., Hidaka, K., Miyata, K., Kamato, T., Nishida, A., & Honda, K. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10449-7 · Cited by 29 · see citing works

SEROTONIN AS A USEFUL PARAMETER FOR COLD AND WARM ISCHEMIC INJURY IN SMALL BOWEL TRANSPLANTATION

Kaihara, S., Egawa, H., Inomata, Y., Üemoto, S., Asonuma, K., & Tanaka, K. (1997) · Transplantation · doi:10.1097/00007890-199708150-00005 · Cited by 17 · see citing works

Cytological and immunocytochemical characterization of the insulin secreting insulinoma cell line RINm5F

Bargsten, G. (2004) · Archivum histologicum japonicum · doi:10.1679/aohc.67.79 · Cited by 13 · see citing works

Serotonin levels in the small bowel mucosa as a marker of ischemic injury during small bowel preservation.

Matia, I., Baláž, P., Jackanin, S., Rybárová, E., Kron, I., Pomfy, M., Froněk, J., & Ryska, M. (2004) · PubMed · Cited by 13 · see citing works

Investigation of 5-HT3 receptor-mediated contraction in guinea-pig distal colon

Yamano, M., & Miyata, K. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00754-6 · Cited by 10 · see citing works

Channeling pain

Patapoutian, A., & Macpherson, L. J. (2006) · Nature Medicine · doi:10.1038/nm0506-506 · Cited by 9 · see citing works

[The neuroendocrine system of the gastrointestinal tract].

Sundler, F., Böttcher, G., Ekblad, E., & Håkanson, R. (1988) · PubMed · Cited by 2 · see citing works

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works

Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways

Bellono, N. W., Bayrer, J. R., Leitch, D. B., Castro, J., Zhang, C., O’Donnell, T. A., Brierley, S. M., Ingraham, H. A., & Julius, D. (2017) · Cell · doi:10.1016/j.cell.2017.05.034 · Cited by 910 · see citing works

Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis

Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Patel, K. V., O’Connor, G., Grati, M., Mittal, J., Yan, D. L. S., Eshraghi, A. A., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25518 · Cited by 644 · see citing works

The gut as a sensory organ

Furness, J. B., Rivera, L. R., Cho, H., Bravo, D. M., & Callaghan, B. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.180 · Cited by 549 · see citing works

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Nilius, B., & SZALLASI, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 504 · see citing works

The functions of TRPA1 and TRPV1: moving away from sensory nerves

Fernandes, E. S., Fernandes, M. A., & Keeble, J. E. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01851.x · Cited by 415 · see citing works

TRPA1: A Gatekeeper for Inflammation

Bautista, D. M., Pellegrino, M., & Tsunozaki, M. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183811 · Cited by 411 · see citing works

Mammalian transient receptor potential TRPA1 channels: from structure to disease.

Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y., Sánchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 365 · see citing works

Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial

Tian, P., Chen, Y., Zhu, H., Wang, L., Qian, X., Zou, R., Zhao, J., Zhang, H., Qian, L., Wang, Q., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.023 · Cited by 365 · see citing works

The transient receptor potential channel TRPA1: from gene to pathophysiology

Nilius, B., Appendino, G., & Owsianik, G. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1158-z · Cited by 337 · see citing works

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways

Ye, L., Bae, M., Cassilly, C. D., Jabba, S. V., Thorpe, D. W., Martin, A. M., Lu, H.-Y., Wang, J., Thompson, J., Lickwar, C. R., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.11.011 · Cited by 321 · see citing works

Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety

Zhu, R., Liu, H., Liu, C., Wang, L., Ma, R., Chen, B., Li, L., Niu, J., Fu, M., Zhang, D., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.019 · Cited by 310 · see citing works

Regulation of Pain and Itch by TRP Channels

Moore, C. D., Gupta, R., Jordt, S., Chen, Y., & Liedtke, W. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0200-8 · Cited by 311 · see citing works

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

Beumer, J., Artegiani, B., Post, Y., Reimann, F. M., Gribble, F. M., Nguyen, T. N., Zeng, H., van den Born, M., van Es, J. H., & Clevers, H. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0143-y · Cited by 280 · see citing works

Serotonin release and uptake in the gastrointestinal tract

Bertrand, P. P., & Bertrand, R. L. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.08.002 · Cited by 272 · see citing works

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804938115 · Cited by 267 · see citing works

The diverse metabolic roles of peripheral serotonin

Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J. (2017) · Endocrinology · doi:10.1210/en.2016-1839 · Cited by 261 · see citing works

Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis

Tian, P., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.007 · Cited by 257 · see citing works

Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

Holzer, P. D. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.006 · Cited by 245 · see citing works

Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation

Nassini, R., Pedretti, P., Moretto, N., Fusi, C., Carnini, C., Facchinetti, F., Viscomi, A. R., Pisano, A. R., Stokesberry, S. A., Brunmark, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042454 · Cited by 237 · see citing works

The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine

Liu, N., Sun, S., Wang, P., Sun, Y., Hu, Q., & Wang, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157931 · Cited by 226 · see citing works

The TRPA1 Channel in Inflammatory and Neuropathic Pain and Migraine

Nassini, R., Materazzi, S., Benemei, S., & Geppetti, P. (2014) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2014_18 · Cited by 210 · see citing works

Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens

Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Microbiome · doi:10.1186/s40168-021-01040-x · Cited by 203 · see citing works

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

Camacho, S., Michlig, S., de Senarclens-Bezençon, C., Meylan, J., Meystre, J., Pezzoli, M., Markram, H., & le Coutre, J. (2015) · Scientific Reports · doi:10.1038/srep07919 · Cited by 189 · see citing works

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents

Baraldi, P. G., Preti, D., Materazzi, S., & Geppetti, P. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100062h · Cited by 175 · see citing works

Inhibitory effect of cannabichromene, a major non‐psychotropic cannabinoid extracted from Cannabis sativa, on inflammation‐induced hypermotility in mice

Izzo, A. A., Capasso, R., Aviello, G., Borrelli, F., Romano, B., Piscitelli, F., Gallo, L., Capasso, F., Orlando, P., & Marzo, V. D. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01879.x · Cited by 171 · see citing works

Serotonin in the gut: Blessing or a curse

Banskota, S., Ghia, J., & Khan, W. I. (2018) · Biochimie · doi:10.1016/j.biochi.2018.06.008 · Cited by 166 · see citing works

Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut–Brain Axis

Engevik, M. A., Luck, B., Visuthranukul, C., Ihekweazu, F. D., Engevik, A. C., Shi, Z., Danhof, H. A., Chang-Graham, A. L., Hall, A., Endres, B. T., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.08.002 · Cited by 164 · see citing works

Gut enterochromaffin cells drive visceral pain and anxiety

Bayrer, J. R., Castro, J., Venkataraman, A., Touhara, K. K., Rossen, N. D., Morrie, R. D., Maddern, J., Hendry, A., Braverman, K. N., Garcia‐Caraballo, S., et al. (2023) · Nature · doi:10.1038/s41586-023-05829-8 · Cited by 163 · see citing works

TRPA1 as a drug target—promise and challenges

Chen, J., & Hackos, D. H. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1088-3 · Cited by 161 · see citing works

Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases

Yu, Y., Yang, W., Li, Y., & Cong, Y. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz217 · Cited by 151 · see citing works

TRPA1 antagonists as potential analgesic drugs

de Andrade, E. L., Meotti, F. C., & Calixto, J. Β. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.10.008 · Cited by 149 · see citing works

Microbiota–neuroepithelial signalling across the gut–brain axis

Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147 · see citing works

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

Brierley, S. M., Castro, J., Harrington, A. M., Hughes, P. A., Page, A. J., Rychkov, G. Y., & Blackshaw, L. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.206789 · Cited by 147 · see citing works

Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells

Mukhopadhyay, I., Gomes, P., Aranake, S., Shetty, M., Karnik, P., Damle, M., Kuruganti, S., Thorat, S., & Khairatkar-Joshi, N. (2011) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2011.602413 · Cited by 146 · see citing works

The TRPA1 channel in migraine mechanism and treatment

Benemei, S., Fusi, C., Trevisan, G., & Geppetti, P. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12512 · Cited by 146 · see citing works

Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors

Gwak, M.-G., & Chang, S. (2021) · Immune Network · doi:10.4110/in.2021.21.e20 · Cited by 143 · see citing works

Upregulation of the Transient Receptor Potential Ankyrin 1 Ion Channel in the Inflamed Human and Mouse Colon and Its Protective Roles

Kun, J., Szitter, I., Kemény, Á., Perkecz, A., Kereskai, L., Pohóczky, K., Vincze, Á., Gódi, S., Szabó, I., Szolcsányi, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108164 · Cited by 137 · see citing works

The gut-to-brain axis for toxin-induced defensive responses

Xie, Z., Zhang, X., Zhao, M., Huo, L., Huang, M., Li, D., Zhang, S., Cheng, X., Gu, H., Zhang, C., et al. (2022) · Cell · doi:10.1016/j.cell.2022.10.001 · Cited by 137 · see citing works

TRPs in Pain Sensation

Jardín, I., López, J. J., Diez, R., Sánchez-Collado, J., Cantonero, C., Albarrán, L., Woodard, G. E., Redondo, P. C., Salido, G. M., Smani, T., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00392 · Cited by 131 · see citing works

Methylglyoxal Evokes Pain by Stimulating TRPA1

Andersson, D. A., Gentry, C., Light, E., Vastani, N., Vallortigara, J., Bierhaus, A., Fleming, T. H., & Bevan, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077986 · Cited by 131 · see citing works

The outer membrane protein Amuc_1100 of Akkermansia muciniphila promotes intestinal 5-HT biosynthesis and extracellular availability through TLR2 signalling

Wang, J., Xu, W., Wang, R., Cheng, R., Tang, Z., & Zhang, M. (2021) · Food & Function · doi:10.1039/d1fo00115a · Cited by 127 · see citing works

Enteric neuroimmune interactions coordinate intestinal responses in health and disease

Wang, H., Foong, J. P. P., Harris, N. L., & Bornstein, J. C. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00443-1 · Cited by 128 · see citing works

Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice

Cattaruzza, F., Spreadbury, I., Miranda‐Morales, M., Grady, E. F., Vanner, S. J., & Bunnett, N. W. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00221.2009 · Cited by 123 · see citing works

Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori

Sato, A., Sokabe, T., Kashio, M., Yasukochi, Y., Tominaga, M., & Shiomi, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322134111 · Cited by 116 · see citing works

Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation

Liñán-Rico, A., Ochoa‐Cortés, F., Beyder, A., Soghomonyan, S., Zuleta-Alarcón, A., Coppola, V., & Christofi, F. L. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00564 · Cited by 116 · see citing works

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling

Roberts, G. P., Larraufie, P., Richards, P., Kay, R. G., Galvin, S. G., Miedzybrodzka, E. L., Leiter, A. B., Li, H. J., Glasssmith, L. L., Ma, M. K. L., et al. (2019) · Diabetes · doi:10.2337/db18-0883 · Cited by 116 · see citing works

Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine

Kono, T., Kaneko, A., Omiya, Y., Ohbuchi, K., Ohno, N., & Yamamoto, M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00356.2012 · Cited by 116 · see citing works

TRP Channels in the Digestive System

Holzer, P. D. (2010) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111793937862 · Cited by 115 · see citing works

Involvement of TRPV2 Activation in Intestinal Movement through Nitric Oxide Production in Mice

Mihara, H., Boudaka, A., Shibasaki, K., Yamanaka, A., Sugiyama, T., & Tominaga, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4426-10.2010 · Cited by 114 · see citing works

Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence

Lai, N. Y., Mills, K. R., & Chiu, I. M. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12591 · Cited by 113 · see citing works

A Western Diet Increases Serotonin Availability in Rat Small Intestine

Bertrand, R. L., Senadheera, S. N., Markus, I., Liu, L., Howitt, L., Chen, H., Murphy, T. V., Sandow, S. L., & Bertrand, P. P. (2010) · Endocrinology · doi:10.1210/en.2010-0377 · Cited by 102 · see citing works

TRPA1 and other TRP channels in migraine

Benemei, S., Cesaris, F. D., Fusi, C., Rossi, E., Lupi, C., & Geppetti, P. (2013) · The Journal of Headache and Pain · doi:10.1186/1129-2377-14-71 · Cited by 100 · see citing works

TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

Moilanen, L., Laavola, M., Kukkonen, M., Korhonen, R., Leppänen, T., Högestätt, E. D., Zygmunt, P. M., Nieminen, R. M., & Moilanen, E. (2012) · Scientific Reports · doi:10.1038/srep00380 · Cited by 91 · see citing works

TRP channels in neurogastroenterology: opportunities for therapeutic intervention

Boesmans, W., Owsianik, G., Tack, J. F., Voets, T., & Berghe, P. V. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01009.x · Cited by 90 · see citing works

Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine

Poole, D. P., Pelayo, J. C., Cattaruzza, F., Kuo, Y., Gai, G., Chiu, J. V., Bron, R., Furness, J. B., Grady, E. F., & Bunnett, N. W. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.049 · Cited by 90 · see citing works

Mechanosensitive Piezo Channels in the Gastrointestinal Tract

Alcaino, C., Farrugia, G., & Beyder, A. (2017) · Current topics in membranes · doi:10.1016/bs.ctm.2016.11.003 · Cited by 89 · see citing works

Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity

Derbenev, A. V., & Zsombok, A. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0529-x · Cited by 89 · see citing works

The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain

Hossain, M. Z., Bakri, M. M., Yahya, F., Ando, H., Unno, S., & Kitagawa, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030526 · Cited by 88 · see citing works

Enteroendocrine cell regulation of the gut-brain axis

Barton, J. R., Londregan, A., Alexander, T. D., Entezari, A. A., Covarrubias, M., & Waldman, S. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1272955 · Cited by 90 · see citing works

Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity

Balemans, D., Boeckxstaens, G. E., Talavera, K., & Wouters, M. M. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00401.2016 · Cited by 85 · see citing works

Identification of enteroendocrine cells that express TRPA1 channels in the mouse intestine

Cho, H., Callaghan, B. P., Bron, R., Bravo, D. M., & Furness, J. B. (2014) · Cell and Tissue Research · doi:10.1007/s00441-013-1780-x · Cited by 84 · see citing works

TRPA1 Is a Polyunsaturated Fatty Acid Sensor in Mammals

Motter, A. L., & Ahern, G. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038439 · Cited by 83 · see citing works

TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway

Du, E. J., Ahn, T. J., Kwon, I., Lee, J. H., Park, J.-H., Park, S. H., Kang, T. M., Cho, H., Kim, T. J., Kim, H.-W., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005773 · Cited by 83 · see citing works

Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat

Zhao, H., Sprunger, L. K., & Simasko, S. M. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00396.2009 · Cited by 82 · see citing works

TRP channels: new targets for visceral pain

Blackshaw, L. A., Brierley, S. M., & Hughes, P. A. (2009) · Gut · doi:10.1136/gut.2009.179523 · Cited by 79 · see citing works

Blastocystis: A Mysterious Member of the Gut Microbiome

Aykur, M., Malatyalı, E., Demirel, F., Koçak, B. C., Gentekaki, E., Tsaousis, A. D., & Al, F. D. (2024) · Microorganisms · doi:10.3390/microorganisms12030461 · Cited by 79 · see citing works

Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity

Zhou, Y., Suzuki, Y., Uchida, K., & Tominaga, M. (2013) · Nature Communications · doi:10.1038/ncomms3399 · Cited by 79 · see citing works

Identification of unique release kinetics of serotonin from guinea‐pig and human enterochromaffin cells

Raghupathi, R., Duffield, M. D., Zelkas, L., Meedeniya, A. C. B., Brookes, S. J., Sia, T. C., Wattchow, D. A., Spencer, N. J., & Keating, D. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.259796 · Cited by 79 · see citing works

Artepillin C, a Major Ingredient of Brazilian Propolis, Induces a Pungent Taste by Activating TRPA1 Channels

Hata, T., Tazawa, S., Ohta, S., Rhyu, M., Misaka, T., & Ichihara, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048072 · Cited by 77 · see citing works

Chemoreceptors in the Gut

Steensels, S., & Depoortere, I. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121332 · Cited by 78 · see citing works

Neural signalling of gut mechanosensation in ingestive and digestive processes

Kim, M., Heo, G., & Kim, S. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00544-7 · Cited by 79 · see citing works

Ingestion of Cinnamaldehyde, a TRPA1 Agonist, Reduces Visceral Fats in Mice Fed a High-Fat and High-Sucrose Diet

TAMURA, Y., Iwasaki, Y., Narukawa, M., & Watanabe, T. (2012) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.58.9 · Cited by 76 · see citing works

Transient Receptor Potential Vanilloid 4 (TRPV4) Is Downregulated in Keratinocytes in Human Non-Melanoma Skin Cancer

Fusi, C., Materazzi, S., Minocci, D., Maio, V., Oranges, T., Massi, D., & Nassini, R. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.145 · Cited by 76 · see citing works

TRP Channels as Sensors of Bacterial Endotoxins

Boonen, B., Alpizar, Y. A., Meseguer, V., & Talavera, K. (2018) · Toxins · doi:10.3390/toxins10080326 · Cited by 75 · see citing works

The Role of TRPA1 in Skin Physiology and Pathology

Maglie, R., de Araújo, D. S. M., Antiga, E., Geppetti, P., Nassini, R., & Logu, F. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063065 · Cited by 76 · see citing works

Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1

Rhyu, M., Kim, Y., & Lyall, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073360 · Cited by 75 · see citing works

QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells

Doihara, H., Nozawa, K., Kojima, R., Kawabata-Shoda, E., Yokoyama, T., & Ito, H. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0165-7 · Cited by 72 · see citing works

Polysulfide Evokes Acute Pain through the Activation of Nociceptive TRPA1 in Mouse Sensory Neurons

Hatakeyama, Y., Takahashi, K., Tominaga, M., Kimura, H., & Ohta, T. (2015) · Molecular Pain · doi:10.1186/s12990-015-0023-4 · Cited by 72 · see citing works

Artepillin C: A comprehensive review of its chemistry, bioavailability, and pharmacological properties

Shahinozzaman, M., Basak, B., Emran, R., Rozario, P., & Obanda, D. N. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104775 · Cited by 72 · see citing works

Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat

Due, M. R., Park, J., Zheng, L., Walls, M. K., Allette, Y. M., White, F. A., & Shi, R. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12500 · Cited by 69 · see citing works

TRPV3, a thermosensitive channel is expressed in mouse distal colon epithelium

Ueda, T., Yamada, T., Ugawa, S., Ishida, Y., & Shimada, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.03.143 · Cited by 68 · see citing works

Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain

Kojima, R., Nozawa, K., Doihara, H., Keto, Y., Kaku, H., Yokoyama, T., & Itou, H. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.020 · Cited by 67 · see citing works

The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the Epithelium

Walsh, K. T., & Zemper, A. E. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.05.003 · Cited by 65 · see citing works

Integrative physiology of depression and antidepressant drug action: Implications for serotonergic mechanisms of action and novel therapeutic strategies for treatment of depression

Hale, M. W., Raison, C. L., & Lowry, C. A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.005 · Cited by 64 · see citing works

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Wang, Z., Ye, D., Ye, J., Wang, M., Liu, J., Jiang, H., Xu, Y. Q., Zhang, J., Chen, J., & Wan, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01253 · Cited by 64 · see citing works

Neurochemical mechanisms and pharmacologic strategies in managing nausea and vomiting related to cyclic vomiting syndrome and other gastrointestinal disorders

Bashashati, M., & McCallum, R. W. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.09.075 · Cited by 63 · see citing works

Metagenomic and metabolomic analysis of the toxic effects of trichloroacetamide-induced gut microbiome and urine metabolome perturbations in mice

Zhang, Y., Zhao, F., Deng, Y., Zhao, Y., & Ren, H. (2015) · Journal of Proteome Research · doi:10.1021/pr5011263 · Cited by 62 · see citing works

Gut microbiota alteration after cholecystectomy contributes to post-cholecystectomy diarrhea via bile acids stimulating colonic serotonin

Xu, Y., Wang, J., Wu, X., Jing, H., Zhang, S., Hu, Z., Rao, L., Chang, Q., Wang, L., & Zhang, Z. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2168101 · Cited by 61 · see citing works

Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction

Wei, L., Singh, R., & Ghoshal, U. C. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm22008 · Cited by 65 · see citing works

Involvement of TRPA1 Activation in Acute Pain Induced by Cadmium in Mice

Miura, S., Takahashi, K., Imagawa, T., Uchida, K., Saito, S., Tominaga, M., & Ohta, T. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-7 · Cited by 60 · see citing works

Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9

Kubota, K., Ohtake, N., Ohbuchi, K., Mase, A., Imamura, S., Sudo, Y., Miyano, K., Yamamoto, M., Kono, T., & Uezono, Y. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00114.2014 · Cited by 60 · see citing works

Enteroendocrine cell lineages that differentially control feeding and gut motility

Hayashi, M., Kaye, J., Douglas, E., Joshi, N. R., Gribble, F., Reimann, F., & Liberles, S. (2022) · bioRxiv · doi:10.7554/elife.78512 · Cited by 48 · see citing works

Essential Amino Acid Metabolites as Chemical Mediators of Host-Microbe Interaction in the Gut

McCann, J. R., & Rawls, J. F. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-032421-111819 · Cited by 59 · see citing works

Chemo‐nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels

Mitrovic, M., Shahbazian, A., Bock, E., Pabst, M. A., & Holzer, P. D. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00794.x · Cited by 59 · see citing works

TRPA1 expression and its functional activation in rodent cortex

Kheradpezhouh, E., Choy, J. M. C., Daria, V. R., & Arabzadeh, E. (2017) · Open Biology · doi:10.1098/rsob.160314 · Cited by 59 · see citing works

TRPA1 agonists delay gastric emptying in rats through serotonergic pathways

Doihara, H., Nozawa, K., Kawabata-Shoda, E., Kojima, R., Yokoyama, T., & Ito, H. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0435-7 · Cited by 58 · see citing works

Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review

Bioque, M., González-Rodríguez, A., García‐Rizo, C., Cobo, J., Monreal, J. A., Usall, J., Soria, V., & Labad, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110130 · Cited by 58 · see citing works

The TRPA1 Agonist, Methyl Syringate Suppresses Food Intake and Gastric Emptying

Kim, M. J., Son, H. J., Song, S. H., Jung, M., Kim, Y., & Rhyu, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071603 · Cited by 57 · see citing works

Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs

Doihara, H., Nozawa, K., Kawabata-Shoda, E., Kojima, R., Yokoyama, T., & Ito, H. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.038 · Cited by 56 · see citing works

QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells

Doihara, H., Nozawa, K., Kojima, R., Kawabata-Shoda, E., Yokoyama, T., & Ito, H. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0165-7 · Cited by 72 · see citing works

Dynamics and regulation of serotonin release in the intestinal epithelium

Rossen, N. D. (2025) · eScholarship (California Digital Library)

5‐HT secretion by enterochromaffin cells is a very touching story

Galligan, J. J. (2016) · The Journal of Physiology · doi:10.1113/jp273041 · Cited by 8 · see citing works

p-chlorophenylalanine depletion of gastrointestinal 5-hydroxytryptamine

Weber, L. J. (1970) · Biochemical Pharmacology · doi:10.1016/0006-2952(70)90317-5 · Cited by 25 · see citing works

Identification of enteroendocrine cells that express TRPA1 channels in the mouse intestine

Cho, H., Callaghan, B. P., Bron, R., Bravo, D. M., & Furness, J. B. (2014) · Cell and Tissue Research · doi:10.1007/s00441-013-1780-x · Cited by 84 · see citing works