The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Deep neural network improves fracture detection by clinicians
Open accessAbstract
Significance: Historically, computer-assisted detection (CAD) in radiology has failed to achieve improvements in diagnostic accuracy, decreasing clinician sensitivity and leading to unnecessary further diagnostic tests. With the advent of deep learning approaches to CAD, there is great excitement about its application to medicine, yet there is little evidence demonstrating improved diagnostic accuracy in clinically-relevant applications. We trained a deep learning model to detect fractures on radiographs with a diagnostic accuracy similar to that of senior subspecialized orthopedic surgeons. We demonstrate that when emergency medicine clinicians are provided with the assistance of the trained model, their ability to accurately detect fractures significantly improves.
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U-Net: Convolutional Networks for Biomedical Image Segmentation
Ronneberger, O., Fischer, P., & Brox, T. (2015) · Lecture notes in computer science · doi:10.1007/978-3-319-24574-4_28 · Cited by 99,404
Adam: A Method for Stochastic Optimization
Kingma, D. P., & Ba, J. (2014) · arXiv · doi:10.48550/arxiv.1412.6980 · Cited by 98,946
LeCun, Y., Bengio, Y., & Hinton, G. (2015) · Nature · doi:10.1038/nature14539 · Cited by 84,126
Dermatologist-level classification of skin cancer with deep neural networks
Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swetter, S. M., Blau, H. M., & Thrun, S. (2017) · Nature · doi:10.1038/nature21056 · Cited by 14,362
Gulshan, V., Peng, L., Coram, M., Stumpe, M. C., Wu, D., Narayanaswamy, A., Venugopalan, S., Widner, K., Madams, T., Cuadros, J., et al. (2016) · JAMA · doi:10.1001/jama.2016.17216 · Cited by 7,697
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DiCiccio, T. J., & Efron, B. (1996) · Statistical Science · doi:10.1214/ss/1032280214 · Cited by 2,286
Mitosis Detection in Breast Cancer Histology Images with Deep Neural Networks
Cireşan, D. C., Giusti, A., Gambardella, L. M., & Schmidhuber, J. (2013) · Lecture Notes in Computer Science · doi:10.1007/978-3-642-40763-5_51 · Cited by 1,536
Sirinukunwattana, K., Raza, S. E. A., Tsang, Y.-W., Snead, D. R. J., Cree, I. A., & Rajpoot, N. M. (2016) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2016.2525803 · Cited by 1,224
Prevalence of Diabetic Retinopathy in the United States, 2005-2008
Zhang, X., Saaddine, J. B., Chou, C.-F., Cotch, M. F., Cheng, Y. J., Geiss, L. S., Gregg, E. W., Albright, A. L., Klein, B. E. K., & Klein, R. (2010) · JAMA · doi:10.1001/jama.2010.1111 · Cited by 1,196
Diagnostic Accuracy of Digital Screening Mammography With and Without Computer-Aided Detection
Lehman, C. D., Wellman, R. D., Buist, D. S. M., Kerlikowske, K., Tosteson, A. N. A., & Miglioretti, D. L. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.5231 · Cited by 678
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Topol, E. J. (2019) · Nature Medicine · doi:10.1038/s41591-018-0300-7 · Cited by 10,450
Key challenges for delivering clinical impact with artificial intelligence
Kelly, C. J., Karthikesalingam, A., Suleyman, M., Corrado, G., & King, D. (2019) · BMC Medicine · doi:10.1186/s12916-019-1426-2 · Cited by 3,136
Liu, X., Faes, L., Kale, A. U., Wagner, S. K., Fu, D. J., Bruynseels, A., Mahendiran, T., Moraes, G., Shamdas, M., Kern, C., et al. (2019) · The Lancet Digital Health · doi:10.1016/s2589-7500(19)30123-2 · Cited by 1,883
Rethinking drug design in the artificial intelligence era
Schneider, P., Walters, W. P., Plowright, A. T., Sieroka, N., Listgarten, J., Goodnow, R. A., Fisher, J., Jansen, J. M., Duca, J. S., Rush, T. S., et al. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0050-3 · Cited by 894
Larrazabal, A. J., Nieto, N., Peterson, V., Milone, D. H., & Ferrante, E. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919012117 · Cited by 685
Metadata
- Authors
- Lindsey, R., Daluiski, A., Chopra, S., Lachapelle, A., Mozer, M., Sicular, S., Hanel, D., Gardner, M., Gupta, A., Hotchkiss, R., & Potter, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-10-22
- Volume
- 115
- Issue
- 45
- Pages
- 11591-11596
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2897228760
- Cited by
- 640
- References
- 19
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lindsey, R., Daluiski, A., Chopra, S., Lachapelle, A., Mozer, M., Sicular, S., Hanel, D., Gardner, M., Gupta, A., Hotchkiss, R., & Potter, H. (2018). Deep neural network improves fracture detection by clinicians. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1806905115
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