The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Regulation of myelin structure and conduction velocity by perinodal astrocytes
Open accessAbstract
Significance: Proper communication between brain regions, via white matter tracts, allows us to carry out complex cognitive and motor tasks. Impulses traveling must arrive at relay points almost simultaneously for such communication to be effective. Myelin enables saltatory conduction of impulses and hence is a candidate for modulation of impulse conduction velocity. But myelin structure, once formed, has been considered static. In this study, we show that mature myelin structure is dynamic. The mature myelin sheath thickness and nodal gap length can be reversibly modulated to optimize the speed of axonal impulses. This modulation of myelin is regulated by exocytosis of thrombin protease inhibitors from astrocytes at the node of Ranvier.
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Cites
White matter in learning, cognition, and psychiatric disorders
Fields, R. D. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.04.001 · Cited by 1,337
Self-citationAstrocytic Purinergic Signaling Coordinates Synaptic Networks
Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280
Scaling Brain Size, Keeping Timing: Evolutionary Preservation of Brain Rhythms
Buzsáki, G., Logothetis, N., & Singer, W. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.002 · Cited by 886
Determinants of conduction velocity in myelinated nerve fibers
Waxman, S. G. (1980) · Muscle & Nerve · doi:10.1002/mus.880030207 · Cited by 629
Role of myelin plasticity in oscillations and synchrony of neuronal activity
Pajevic, S., Basser, P. J., & Fields, R. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.007 · Cited by 378
Self-citationLearning-enhanced coupling between ripple oscillations in association cortices and hippocampus
Khodagholy, D., Gelinas, J. N., & Buzsáki, G. (2017) · Science · doi:10.1126/science.aan6203 · Cited by 357
Reactivations of emotional memory in the hippocampus-amygdala system during sleep
Girardeau, G., Inema, I., & Buzsáki, G. (2017) · Nature Neuroscience · doi:10.1038/nn.4637 · Cited by 266
Cited by
Myelin in the Central Nervous System: Structure, Function, and Pathology
Stadelmann, C., Timmler, S., Barrantes-Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 728
Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration
Molina-Gonzalez, I., Holloway, R. K., Jiwaji, Z., Dando, O., Kent, S. A., Emelianova, K., Lloyd, A. F., Forbes, L. H., Mahmood, A., Skripuletz, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39046-8 · Cited by 176
“Astrocytes are promising therapeutic targets as they are the most abundant glial cell type in the CNS and communicate with oligodendrocytes in development to support initial myelin formation 9,10 , yet their role in remyelination is understudied and controversial 11 – 14 .”
Beyond the gut: decoding the gut–immune–brain axis in health and disease
Park, J. C., Chang, L., Kwon, H.-K., & Im, S.-H. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01333-3 · Cited by 149
Noori, R., Park, D., Griffiths, J. D., Bells, S., Frankland, P. W., Mabbott, D., & Lefebvre, J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916646117 · Cited by 137
Regulation of myelination by microglia
Santos, E. N., & Fields, R. D. (2021) · Science Advances · doi:10.1126/sciadv.abk1131 · Cited by 137
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Metadata
- Authors
- Dutta, D. J., Woo, D. H., Lee, P. R., Pajevic, S., Bukalo, O., Huffman, W. C., Wake, H., Basser, P. J., SheikhBahaei, S., Lazarevic, V., Smith, J. C., & Fields, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-10-29
- Volume
- 115
- Issue
- 46
- Pages
- 11832-11837
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2899141782
- Cited by
- 200
- References
- 7
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dutta, D. J., Woo, D. H., Lee, P. R., Pajevic, S., Bukalo, O., Huffman, W. C., Wake, H., Basser, P. J., SheikhBahaei, S., Lazarevic, V., Smith, J. C., & Fields, R. D. (2018). Regulation of myelin structure and conduction velocity by perinodal astrocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1811013115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
