The DOI matches its Crossref record; 655 of the 655 references it cites were found in a registry or an index.
Myelin in the Central Nervous System: Structure, Function, and Pathology
Open accessAbstract
Oligodendrocytes generate multiple layers of myelin membrane around axons of the central nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve conduction was considered the only purpose of myelin, but it is now clear that myelin has more functions. In fact, myelinating oligodendrocytes are embedded in a vast network of interconnected glial and neuronal cells, and increasing evidence supports an active role of oligodendrocytes within this assembly, for example, by providing metabolic support to neurons, by regulating ion and water homeostasis, and by adapting to activity-dependent neuronal signals. The molecular complexity governing these interactions requires an in-depth molecular understanding of how oligodendrocytes and axons interact and how they generate, maintain, and remodel their myelin sheaths. This review deals with the biology of myelin, the expanded relationship of myelin with its underlying axons and the neighboring cells, and its disturbances in various diseases such as multiple sclerosis, acute disseminated encephalomyelitis, and neuromyelitis optica spectrum disorders. Furthermore, we will highlight how specific interactions between astrocytes, oligodendrocytes, and microglia contribute to demyelination in hereditary white matter pathologies.
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Cites
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Astrocytes: Biology and pathology
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International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
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Self-citationA serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
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“The concept that glial cells contribute to neuronal metabolism was initially proposed for astrocytes and led to the astrocyte-neuron lactate shuttle hypothesis (295, 464).”
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Cited by
White matter aging drives microglial diversity
Safaiyan, S., Besson-Girard, S., Kaya, T., Cantuti-Castelvetri, L., Liu, L., Ji, H., Schifferer, M., Gouna, G., Usifo, F., Kannaiyan, N., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.027 · Cited by 477
Self-citationDiagnosis and classification of optic neuritis
Petzold, A., Fraser, C. L., Abegg, M., Alroughani, R., Alshowaeir, D., Alvarenga, R., Andris, C., Asgari, N., Barnett, Y., Battistella, R., et al. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00200-9 · Cited by 330
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging
Kaya, T., Mattugini, N., Liu, L., Ji, H., Cantuti-Castelvetri, L., Wu, J., Schifferer, M., Groh, J., Martini, R., Besson-Girard, S., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01183-6 · Cited by 224
Self-citationCNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
Franklin, R. J. M., & Simons, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.023 · Cited by 184
Self-citationWhite matter aging and its impact on brain function
Groh, J., & Simons, M. (2025) · Neuron · doi:10.1016/j.neuron.2024.10.019 · Cited by 124
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Metadata
- Authors
- Stadelmann, C., Timmler, S., Barrantes-Freer, A., & Simons, M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2019-07-01
- Volume
- 99
- Issue
- 3
- Pages
- 1381-1431
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2944786249
- Cited by
- 728
- References
- 655
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
