Relation between blood pressure and pulse wave velocity for human arteries
Open accessAbstract
Significance: Continuous, cuffless, and noninvasive blood pressure monitoring by measuring the pulse wave velocity is generally considered to be a promising technique for noninvasive measurements. Previously reported relations between blood pressure and pulse wave velocity relation involve unrealistic assumptions that do not hold for human arteries, and also rely on empirical expressions without any theoretical basis. Here, an analytical model without such assumptions or empirical expressions is established to yield a relation between blood pressure and pulse wave velocity that has general utility for future work in continuous, cuffless, and noninvasive blood pressure monitoring.
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Both PAT and PTT depend on vascular system geometry, elasticity, SBP, and other factors.
“Ultimately, both PAT and PTT depend on vascular system geometry, elasticity, SBP, and other factors30,33,34.”
From Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units (2020) · cites this paper as [30]
The In Vitro Experiments section relates pulse transit time to pulse wave velocity and reports pulse arrival times measured with ECG and PPG. It also states that the pressure–velocity relation depends on arterial material properties and geometry. The reported human measurements concern diastolic blood pressure, however, so the paper does not establish the stated dependence on SBP for both PAT and PTT. (LLM, conf=0.84)
Experimental — accuracy not yet measuredExtensive studies on adult subjects establish calibrated correlations between PAT, PTT and SBP using both empirical and theoretical models, some of which are clinically approved for monitoring in certain scenarios.
“Extensive studies on adult subjects establish calibrated correlations between PAT, PTT and SBP using both empirical and theoretical models30, some of which are clinically approved for monitoring in certain scenarios (e.g. Sotera ViSi Mobile® System).”
From Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units (2020) · cites this paper as [30]
The In Vitro Experiments section (page not provided) reports a calibrated relationship between pulse arrival time and blood pressure in human subjects, and describes a theoretical pressure–pulse-wave-velocity model alongside an empirical equation. Its reported human measurements concern diastolic blood pressure, not an established PAT/PTT–systolic blood pressure correlation across extensive adult studies. The copy also does not establish clinical approval of a monitoring system such as Sotera ViSi Mobile. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPAT and PTT are two related but distinct measures with established correlations to systolic BP.
“Pulse arrival time (PAT) and pulse transit time (PTT) are two related but distinct measures with established correlations to systolic BP (SBP)30.”
From Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units (2020) · cites this paper as [30]
The In Vitro Experiments section describes pulse arrival time measurements and evaluates their correlation with blood pressure, specifically reporting a relationship with diastolic blood pressure. It also relates pulse-wave velocity to the time between pulses at two sensors. The copy does not establish correlations of both PAT and PTT with systolic blood pressure or explicitly distinguish the two measures. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPulse arrival time serves as a surrogate measurement for blood pressure.
“The outputs of the chest and limb sensors are then capable of calculating pulse arrival time (PAT), which serves as a surrogate measurement for BP (24, 25).”
From Comprehensive pregnancy monitoring with a network of wireless, soft, and flexible sensors in high- and low-resource health settings (2021) · cites this paper as [25]
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References 35 · Cited by 309
- Authors
- Ma, Y., Choi, J., Hourlier-Fargette, A., Xue, Y., Chung, H. U., Lee, J. Y., Wang, X., Xie, Z., Kang, D., Wang, H., Han, S., Kang, S.-K., Kang, Y., Yu, X., Slepian, M. J., Raj, M. S., Model, J. B., Feng, X., Ghaffari, R., Rogers, J. A., & Huang, Y.
- Affiliations
- Tsinghua University (CN)
- Northwestern University (US)
- Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;
- Xiangtan University (CN)
- Ajou University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- University of Illinois Urbana-Champaign (US)
- City University of Hong Kong (HK)
- University of Arizona (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-10-15
- Volume
- 115
- Issue
- 44
- Pages
- 11144-11149
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6217416
- OpenAlex
- W2896545929
- Cited by
- 309
- References
- 35
- Citations by year
- 2026: 27 · 2025: 43 · 2024: 40 · 2023: 44 · 2022: 49 · 2021: 50 · 2020: 36 · 2019: 19 · 2018: 1
- FWCI
- 20.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Basic Research Program of China (2015CB351900)
- National Natural Science Foundation of China (11402135, 11625207, 11320101001, 11222220)
- National Science Foundation (1400169, 1534120, 1635443)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Keywords
- pulse wave velocity, blood pressure, human arteries, cuffless blood pressure measurement, non-invasive blood pressure measurement, arterial wall mechanics, analytical model, continuous blood pressure monitoring
- MeSH terms
- Arteries, Blood Flow Velocity, Blood Pressure, Blood Pressure Determination, Electrocardiography, Humans, Monitoring, Physiologic, Pulsatile Flow, Pulse Wave Analysis
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