Reply to Gronwald et al. Exercise intensity does indeed matter; maximal oxygen uptake is the gold-standard indicator.
Open accessAbstract
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most research on interindividual heterogeneity in response to acute and regular physical exercising has focused on non-modifiable factors such as sex and different genotypes, while relatively little attention has been paid to exercise prescription as a modifiable factor.
“In an attempt to better understand this interindividual heterogeneity in response to acute and regular physical exercising, most research, so far, has focused on non-modifiable factors such as sex and different genotypes, while relatively little attention has been paid to exercise prescription as a modifiable factor.”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Suwabe et al., 2018
Not all scientific disciplines investigating exercise-cognition are taking the issue of optimal exercise prescription parameters into account sufficiently.
“Notably, what parameters are optimal to prescribe the best exercise for an individual is extensively discussed in the literature (Katch et al., 1978; Weltman et al., 1989, 1990; Gass et al., 1991; Meyer et al., 1999; Hofmann and Tschakert, 2010; Scharhag-Rosenberger et al., 2010; Mann et al., 2013; Weatherwax et al., 2016), but not all scientific disciplines investigating exercise–cognition are ta”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Suwabe et al., 2018
Cites
Borg's Perceived Exertion and Pain Scales
Borg, G. A. V. (1998) · Cited by 3,366 · see citing works
Borg's Perceived Exertion and Pain Scales
Heath, E. M. (1998) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199809000-00018 · Cited by 3,049 · see citing works
Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574 · see citing works
Yanagisawa, H., Dan, I., Tsuzuki, D., Kato, M., Okamoto, M., Kyutoku, Y., & Soya, H. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.023 · Cited by 634 · see citing works
Self-citationByun, K., Hyodo, K., Suwabe, K., Ochi, G., Sakairi, Y., Kato, M., Dan, I., & Soya, H. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.04.067 · Cited by 435 · see citing works
Self-citationBDNF induction with mild exercise in the rat hippocampus
Soya, H., Nakamura, T., Deocaris, C. C., Kimpara, A., Iimura, M., Fujikawa, T., Chang, H., McEwen, B. S., & Nishijima, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.173 · Cited by 269 · see citing works
Self-citationRapid stimulation of human dentate gyrus function with acute mild exercise
Suwabe, K., Byun, K., Hyodo, K., Reagh, Z. M., Roberts, J. M., Matsushita, A., Saotome, K., Ochi, G., Fukuie, T., Suzuki, K., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805668115 · Cited by 174 · see citing works
Self-citationOkamoto, M., Hojo, Y., Inoue, K., Matsui, T., Kawato, S., McEwen, B. S., & Soya, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210023109 · Cited by 157 · see citing works
Self-citationMcKay, G., & Banister, E. W. (1976) · European Journal of Applied Physiology · doi:10.1007/bf02336193 · Cited by 105 · see citing works
Acute moderate exercise improves mnemonic discrimination in young adults
Suwabe, K., Hyodo, K., Byun, K., Ochi, G., Yassa, M. A., & Soya, H. (2016) · Hippocampus · doi:10.1002/hipo.22695 · Cited by 99 · see citing works
Self-citationIncreasing exercise’s effect on mental health: Exercise intensity does matter
Gronwald, T., Velasques, B., Ribeiro, P. F. M., Machado, S. E. D. C., Murillo‐Rodríguez, E., Ludyga, S., Yamamoto, T., & Budde, H. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818161115 · Cited by 43 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research
Herold, F., Müller, P., Gronwald, T., & Müller, N. G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02338 · Cited by 196 · see citing works
Herold, F., Törpel, A., Hamacher, D., Budde, H., Zou, L., Strobach, T., Müller, N. G., & Gronwald, T. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.682891 · Cited by 73 · see citing works
Herold, F., Törpel, A., Hamacher, D., Budde, H., & Gronwald, T. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030055 · Cited by 47 · see citing works
Herold, F., Gronwald, T., Scholkmann, F., Zohdi, H., Wyser, D., Müller, N. G., & Hamacher, D. (2020) · Brain Sciences · doi:10.3390/brainsci10060342 · Cited by 40 · see citing works
A fitness training optimization system based on heart rate prediction under different activities
Zhu, Z., Li, H., Xiao, J. K., Xu, W., & Huang, M.-C. (2022) · Methods · doi:10.1016/j.ymeth.2022.06.006 · Cited by 25 · see citing works
Suwabe, K., Yassa, M. A., Suzuki, K., Sankai, Y., & Soya, H. (2025) · Advances in neurobiology · doi:10.1007/978-981-95-0066-6_5 · Cited by 3 · see citing works
Self-citationAntropometria, composição corporal e desempenho motor em escolares
da Silva, J. C. P. L., Ferreira, H. D. S., Junqueira, C. G. S., Medeiros, F. D. S., Araújo, G. D. S., Pires, P. J. D. S., & Frankenfeld, S. P. (2025) · Congresso de Educação Física de Volta Redonda · doi:10.47385/cedvr.2177.6.2025
- Authors
- Suwabe, K., Byun, K., Hyodo, K., Reagh, Z. M., Roberts, J. M., Matsushita, A., Saotome, K., Ochi, G., Fukuie, T., Suzuki, K., Sankai, Y., Yassa, M. A., & Soya, H.
- Affiliations
- University of Tsukuba (JP)
- University of California, Irvine (US)
- Ibaraki Prefectural University of Health Sciences (JP)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-12-12
- Volume
- 115
- Issue
- 51
- Pages
- E11892-E11893
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6304988
- OpenAlex
- W2903824113
- Cited by
- 7
- References
- 11
- Citations by year
- 2025: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- MEXT | Japan Society for the Promotion of Science (18H04081, 16H06405)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- exercise intensity, VO2max, exercise training, cardiorespiratory fitness
- MeSH terms
- Gold, Humans, Oxygen, Oxygen Consumption, Exercise, Dentate Gyrus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
