The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments?
Open accessAbstract
By considering temperature effects on the mechanical unfolding rates of proteins and RNA, whose energy landscape is rugged, the question posed in the title is answered in the affirmative. Adopting a theory by Zwanzig [Zwanzig, R. (1988) Proc. Natl. Acad. Sci. USA 85, 2029-2030], we show that, because of roughness characterized by an energy scale ε, the unfolding rate at constant force is retarded. Similarly, in nonequilibrium experiments done at constant loading rates, the most probable unfolding force increases because of energy landscape roughness. The effects are dramatic at low temperatures. Our analysis suggests that, by using temperature as a variable in mechanical unfolding experiments of proteins and RNA, the ruggedness energy scale ε, can be directly measured.
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Cites
Reaction-rate theory: fifty years after Kramers
Hänggi, P., Talkner, P., & Borkovec, M. (1990) · Reviews of Modern Physics · doi:10.1103/revmodphys.62.251 · Cited by 6,154
Funnels, pathways, and the energy landscape of protein folding: A synthesis
Bryngelson, J. D., Onuchic, J. N., Socci, N. D., & Wolynes, P. G. (1995) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340210302 · Cited by 2,648
From Levinthal to pathways to funnels
Dill, K. A., & Chan, H. S. (1997) · Nature Structural & Molecular Biology · doi:10.1038/nsb0197-10 · Cited by 2,293
Cited by
Ribas-Arino, J., & Marx, D. (2012) · Chemical Reviews · doi:10.1021/cr200399q · Cited by 448
Direct Measurement of the Full, Sequence-Dependent Folding Landscape of a Nucleic Acid
Woodside, M. T., Anthony, P. C., Behnke-Parks, W. M., Larizadeh, K., Herschlag, D., & Block, S. M. (2006) · Science · doi:10.1126/science.1133601 · Cited by 391
Ensemble-based characterization of unbound and bound states on protein energy landscape
Ruvinsky, A. M., Kirys, T., Tuzikov, A. V., & Vakser, I. A. (2013) · Protein Science · doi:10.1002/pro.2256 · Cited by 9
Metadata
- Authors
- Hyeon, C., & Thirumalai, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-08-21
- Volume
- 100
- Issue
- 18
- Pages
- 10249-10253
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967197458
- Cited by
- 165
- References
- 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- green
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