The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Direct Measurement of the Full, Sequence-Dependent Folding Landscape of a Nucleic Acid
Open accessAbstract
Nucleic acid hairpins provide a powerful model system for understanding macromolecular folding, with free-energy landscapes that can be readily manipulated by changing the hairpin sequence. The full shapes of energy landscapes for the reversible folding of DNA hairpins under controlled loads exerted by an optical force clamp were obtained by deconvolution from high-resolution, single-molecule trajectories. The locations and heights of the energy barriers for hairpin folding could be tuned by adjusting the number and location of G:C base pairs, and the presence and position of folding intermediates were controlled by introducing single-nucleotide mismatches.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Protein folding and misfolding
Dobson, C. M. (2003) · Nature · doi:10.1038/nature02261 · Cited by 4,791
Bell, G. I. (1978) · Science · doi:10.1126/science.347575 · Cited by 4,328
Structure and Mechanism in Protein Science
Fersht, A. (1998) · Cited by 1,882
Onuchic, J. N., & Wolynes, P. G. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.01.009 · Cited by 1,301
INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS
Kim, P. S., & Baldwin, R. L. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.003215 · Cited by 1,135
Reversible Unfolding of Single RNA Molecules by Mechanical Force
Liphardt, J., Onoa, B., Smith, S. B., Tinoco, I., & Bustamante, C. (2001) · Science · doi:10.1126/science.1058498 · Cited by 931
Toward High-Resolution de Novo Structure Prediction for Small Proteins
Bradley, P., Misura, K. M. S., & Baker, D. (2005) · Science · doi:10.1126/science.1113801 · Cited by 864
Woodside, M. T., Behnke-Parks, W. M., Larizadeh, K., Travers, K., Herschlag, D., & Block, S. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511048103 · Cited by 474
Self-citationIs there a unifying mechanism for protein folding?
Daggett, V., & Fersht, A. R. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)00012-9 · Cited by 454
Deconvolution of images and spectra
Jansson, P. (1997) · Cited by 411
Cited by
The Complex Folding Network of Single Calmodulin Molecules
Stigler, J., Ziegler, F., Gieseke, A., Gebhardt, J. C. M., & Rief, M. (2011) · Science · doi:10.1126/science.1207598 · Cited by 372
Ferreiro, D. U., Komives, E. A., & Wolynes, P. G. (2014) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583514000092 · Cited by 314
Metadata
- Authors
- Woodside, M. T., Anthony, P. C., Behnke-Parks, W. M., Larizadeh, K., Herschlag, D., & Block, S. M.
- Venue
- Science
- Published
- 2006-11-10
- Volume
- 314
- Issue
- 5801
- Pages
- 1001-1004
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030261975
- Cited by
- 391
- References
- 18
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Direct Measurement of the Full, Sequence-Dependent Folding Landscape of a Nucleic Acid. https://app.cochat.ai/papers/10.1126/science.1133601
- The paper
- Woodside, M. T., Anthony, P. C., Behnke-Parks, W. M., Larizadeh, K., Herschlag, D., & Block, S. M. (2006). Direct Measurement of the Full, Sequence-Dependent Folding Landscape of a Nucleic Acid. Science. https://doi.org/10.1126/science.1133601
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
