The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells
Open accessAbstract
Stem cells (SCs) are functionally defined by their abilities to self-renew and generate differentiated cells. Although much effort has been focused on defining the common characteristics among various types of SCs, the genetic and functional differences between multipotent and pluripotent SCs have garnered less attention. We report a direct genetic and functional comparison of molecularly defined and clonally related populations of neural SCs (NSCs) and embryonic SCs (ESCs), using the Sox2 promoter for isolation of purified populations by fluorescence-activated cell sorting. A stringent expression profile comparison of promoter-defined NSCs and ESCs revealed a striking dissimilarity, and subsequent chimera analyses confirmed the fundamental differences in cellular potency between these populations. This direct comparison elucidates the molecular basis for the functional differences in pluripotent ESCs and multipotent NSCs.
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Cites
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133
Wood, H. B., & Episkopou, V. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00116-1 · Cited by 550
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Metadata
- Authors
- D'Amour, K. A., & Gage, F. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-09-30
- Volume
- 100
- Issue
- suppl_1
- Pages
- 11866-11872
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2125189150
- Cited by
- 209
- References
- 2
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- green
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- D'Amour, K. A., & Gage, F. H. (2003). Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1834200100
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