The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians
Open accessAbstract
Freshwater planarian flatworms are capable of regenerating complete organisms from tiny fragments of their bodies; the basis for this regenerative prowess is an experimentally accessible stem cell population that is present in the adult planarian. The study of these organisms, classic experimental models for investigating metazoan regeneration, has been revitalized by the application of modern molecular biological approaches. The identification of thousands of unique planarian ESTs, coupled with large-scale whole-mount in situ hybridization screens, and the ability to inhibit planarian gene expression through double-stranded RNA-mediated genetic interference, provide a wealth of tools for studying the molecular mechanisms that regulate tissue regeneration and stem cell biology in these organisms. Here we show that, as in Caenorhabditis elegans , ingestion of bacterially expressed double-stranded RNA can inhibit gene expression in planarians. This inhibition persists throughout the process of regeneration, allowing phenotypes with disrupted regenerative patterning to be identified. These results pave the way for large-scale screens for genes involved in regenerative processes.
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Citations
Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Cited by
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
Dietzl, G., Chen, D., Schnorrer, F., Su, K.-C., Barinova, Y., Fellner, M., Gasser, B., Kinsey, K., Oppel, S., Scheiblauer, S., et al. (2007) · Nature · doi:10.1038/nature05954 · Cited by 2,644
Control of coleopteran insect pests through RNA interference
Baum, J. A., Bogaert, T., Clinton, W., Heck, G. R., Feldmann, P., Ilagan, O., Johnson, S., Plaetinck, G., Munyikwa, T., Pleau, M., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1359 · Cited by 1,789
Cell type transcriptome atlas for the planarian Schmidtea mediterranea
Fincher, C. T., Wurtzel, O., de Hoog, T., Kravarik, K. M., & Reddien, P. W. (2018) · Science · doi:10.1126/science.aaq1736 · Cited by 436
Self-citationJuliano, C., Wang, J., & Lin, H. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132541 · Cited by 374
Cebrià, F., & Newmark, P. A. (2005) · Development · doi:10.1242/dev.01941 · Cited by 286
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Metadata
- Authors
- Newmark, P. A., Reddien, P. W., Cebrià, F., & Alvarado, A. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-09-30
- Volume
- 100
- Issue
- suppl_1
- Pages
- 11861-11865
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2023719014
- Cited by
- 301
- References
- 1
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Newmark, P. A., Reddien, P. W., Cebrià, F., & Alvarado, A. S. (2003). Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1834205100
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