The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination
Open accessAbstract
Significance: Vaccine kinetics, the timing of antigen and/or adjuvant delivery to lymphoid organs, have recently been shown to substantially influence immune responses to subunit vaccines, but strategies to control vaccine kinetics in a clinically translatable manner are still lacking. MNs are arrays of solid micron-sized projections that have been utilized in early clinical trials for vaccine delivery. Here, we investigated whether implantable MN skin patches could be used to control vaccine kinetics. We show that sustained intradermal release of an HIV subunit vaccine from MNs enhanced GC responses and significantly improved humoral immunity compared with traditional bolus injections. The findings of this study have strong translational relevance as MNs, such as described here, can provide rapid needle-free vaccine administration.
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Cites
Broad neutralization coverage of HIV by multiple highly potent antibodies
Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J.-P., Wang, S.-K., Ramos, A., Chan-Hui, P.-Y., Moyle, M., et al. (2011) · Nature · doi:10.1038/nature10373 · Cited by 1,480
Self-citationTam, H. H., Melo, M. B., Kang, M., Pelet, J. M., Ruda, V. M., Foley, M. H., Hu, J. K., Kumari, S., Crampton, J., Baldeon, A. D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606050113 · Cited by 425
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Cited by
Kim, E., Erdos, G., Huang, S., Kenniston, T. W., Balmert, S. C., Carey, C. D., Raj, V. S., Epperly, M. W., Klimstra, W. B., Haagmans, B. L., et al. (2020) · eBioMedicine · doi:10.1016/j.ebiom.2020.102743 · Cited by 404
Zhang, X., Chen, G., Liu, Y., Sun, L., Sun, L., & Zhao, Y. (2020) · ACS Nano · doi:10.1021/acsnano.0c01059 · Cited by 363
Recent advances in regenerative biomaterials
Cao, D., & Ding, J. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac098 · Cited by 259
Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects
Hettinga, J., & Carlisle, R. (2020) · Vaccines · doi:10.3390/vaccines8030534 · Cited by 72
Metadata
- Authors
- Boopathy, A. V., Mandal, A., Kulp, D. W., Menis, S., Bennett, N. R., Watkins, H. C., Wang, W., Martin, J. T., Thai, N. T., He, Y., Schief, W. R., Hammond, P. T., & Irvine, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-07-29
- Volume
- 116
- Issue
- 33
- Pages
- 16473-16478
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2964893194
- Cited by
- 198
- References
- 2
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination. https://app.cochat.ai/papers/10.1073/pnas.1902179116
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- Boopathy, A. V., Mandal, A., Kulp, D. W., Menis, S., Bennett, N. R., Watkins, H. C., Wang, W., Martin, J. T., Thai, N. T., He, Y., Schief, W. R., Hammond, P. T., & Irvine, D. J. (2019). Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1902179116
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