The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex
Open accessAbstract
A requirement for scaffolding complexes containing internalized G protein-coupled receptors and β-arrestins in the activation and subcellular localization of extracellular signal-regulated kinases 1 and 2 (ERK1/2) has recently been proposed. However, the composition of these complexes and the importance of this requirement for function of ERK1/2 appear to differ between receptors. Here we report that substance P (SP) activation of neurokinin-1 receptor (NK1R) stimulates the formation of a scaffolding complex comprising internalized receptor, β-arrestin, src, and ERK1/2 (detected by gel filtration, immunoprecipitation, and immunofluorescence). Inhibition of complex formation, by expression of dominant-negative β-arrestin or a truncated NK1R that fails to interact with β-arrestin, inhibits both SP-stimulated endocytosis of the NK1R and activation of ERK1/2, which is required for the proliferative and antiapoptotic effects of SP. Thus, formation of a β-arrestin-containing complex facilitates the proliferative and antiapoptotic effects of SP, and these effects of SP could be diminished in cells expressing truncated NK1R corresponding to a naturally occurring variant.
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Gutkind, J. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1839 · Cited by 812
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Morrison, D. K., & Davis, R. J. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.091942 · Cited by 786
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
Shenoy, S. K., Drake, M. T., Nelson, C. D., Houtz, D. A., Xiao, K., Madabushi, S., Reiter, E., Premont, R. T., Lichtarge, O., & Lefkowitz, R. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506576200 · Cited by 759
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Metadata
- Authors
- DeFea, K. A., Vaughn, Z. D., O'Bryan, E. M., Nishijima, D., Déry, O., & Bunnett, N. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-09-19
- Volume
- 97
- Issue
- 20
- Pages
- 11086-11091
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2159588204
- Cited by
- 405
- References
- 1
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- green
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- DeFea, K. A., Vaughn, Z. D., O'Bryan, E. M., Nishijima, D., Déry, O., & Bunnett, N. W. (2000). The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.190276697
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