Cited by 812Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

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Gutkind, J. Silvio·1998·Journal of Biological Chemistry

Abstract

Receptors coupled to heterotrimeric GTP-binding proteins (G proteins) are integral membrane proteins involved in the transmission of signals from the extracellular environment to the cytoplasm. The best known family of G protein-coupled receptors (GPCRs),1 currently comprising more than 1000 members, exhibits a common structural motif consisting of seven membrane-spanning regions (1) (Fig. 1). A diverse array of external stimuli including neurotransmitters, hormones, phospholipids, photons, odorants, certain taste ligands, and growth factors can activate specific members of this receptor family and promote interaction between the receptor and the G protein on the intracellular side of the membrane.

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Crossref · 10.1074/jbc.273.4.1839

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  • The Ras family of proteins are GTP-dependent molecular switches that are essential for cell growth and differentiation.

    “The Ras family of proteins are GTP-dependent molecular switches that are essential for cell growth and differentiation (61,62).”

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Authors
Gutkind, J. S.
Affiliations
National Institutes of Health (US)
Corresponding author
Gutkind, J. Silvio
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1998-01
Volume
273
Issue
4
Pages
1839-1842
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2107258432
Cited by
812
References
73
Citations by year
2026: 4 · 2025: 4 · 2024: 7 · 2023: 22 · 2022: 2 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 16
FWCI
7.85
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
G protein-coupled receptors, heterotrimeric G proteins, mitogen-activated protein kinase cascade, signal transduction, nuclear signaling, MAPK signaling, receptor-G protein coupling
MeSH terms
Animals, Cell Division, Cell Transformation, Neoplastic, Humans, Models, Biological, Receptors, Cell Surface, Signal Transduction, Calcium-Calmodulin-Dependent Protein Kinases, GTP-Binding Proteins

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