The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades
Open accessAbstract
Receptors coupled to heterotrimeric GTP-binding proteins (G proteins) are integral membrane proteins involved in the transmission of signals from the extracellular environment to the cytoplasm. The best known family of G protein-coupled receptors (GPCRs),1 currently comprising more than 1000 members, exhibits a common structural motif consisting of seven membrane-spanning regions (1) (Fig. 1). A diverse array of external stimuli including neurotransmitters, hormones, phospholipids, photons, odorants, certain taste ligands, and growth factors can activate specific members of this receptor family and promote interaction between the receptor and the G protein on the intracellular side of the membrane.
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The Ras family of proteins are GTP-dependent molecular switches that are essential for cell growth and differentiation.
“The Ras family of proteins are GTP-dependent molecular switches that are essential for cell growth and differentiation (61,62).”
From c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor (1999) · cites this paper as [62]
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- Authors
- Gutkind, J. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Gutkind, J. Silvio
- ORCID
- Gutkind, J. Silvio
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 273
- Issue
- 4
- Pages
- 1839-1842
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2107258432
- Cited by
- 812
- References
- 73
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 22 · 2022: 2 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 16
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- G protein-coupled receptors, heterotrimeric G proteins, mitogen-activated protein kinase cascade, signal transduction, nuclear signaling, MAPK signaling, receptor-G protein coupling
- MeSH terms
- Animals, Cell Division, Cell Transformation, Neoplastic, Humans, Models, Biological, Receptors, Cell Surface, Signal Transduction, Calcium-Calmodulin-Dependent Protein Kinases, GTP-Binding Proteins
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