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Cited by 489

The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.

Gradients of structure–function tethering across neocortex

Open access
Vázquez-Rodríguez, Bertha, Suárez, Laura E., Markello, Ross D., Shafiei, Golia, Paquola, Casey, Hagmann, Patric, van den Heuvel, Martijn P., Bernhardt, Boris C., Spreng, R. Nathan, Misic, Bratislav·2019·Proceedings of the National Academy of Sciences

Abstract

The white matter architecture of the brain imparts a distinct signature on neuronal coactivation patterns. Interregional projections promote synchrony among distant neuronal populations, giving rise to richly patterned functional networks. A variety of statistical, communication, and biophysical models have been proposed to study the relationship between brain structure and function, but the link is not yet known. In the present report we seek to relate the structural and functional connection profiles of individual brain areas. We apply a simple multilinear model that incorporates information about spatial proximity, routing, and diffusion between brain regions to predict their functional connectivity. We find that structure–function relationships vary markedly across the neocortex. Structure and function correspond closely in unimodal, primary sensory, and motor regions, but diverge in transmodal cortex, particularly the default mode and salience networks. The divergence between structure and function systematically follows functional and cytoarchitectonic hierarchies. Altogether, the present results demonstrate that structural and functional networks do not align uniformly across the brain, but gradually uncouple in higher-order polysensory areas.

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Crossref · 10.1073/pnas.1903403116

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Metadata

Authors
Vázquez-Rodríguez, B., Suárez, L. E., Markello, R. D., Shafiei, G., Paquola, C., Hagmann, P., van den Heuvel, M. P., Bernhardt, B. C., Spreng, R. N., & Misic, B.
Venue
Proceedings of the National Academy of Sciences
Published
2019-09-30
Volume
116
Issue
42
Pages
21219-21227
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2978356506
Cited by
489
References
95
FWCI
25.96
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Gradients of structure–function tethering across neocortex. https://app.cochat.ai/papers/10.1073/pnas.1903403116
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Vázquez-Rodríguez, B., Suárez, L. E., Markello, R. D., Shafiei, G., Paquola, C., Hagmann, P., van den Heuvel, M. P., Bernhardt, B. C., Spreng, R. N., & Misic, B. (2019). Gradients of structure–function tethering across neocortex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1903403116

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.