Arousal regulates frequency tuning in primary auditory cortex
Open accessAbstract
Significance: Changes in brain state modulate how information is processed in sensory cortical areas. Here we use population imaging and intracellular recording to show that arousal regulates frequency tuning in layer 2/3 of primary auditory cortex. Increased arousal reduces lateral inhibition, broadens frequency tuning and enhances cortical representations of pure tones. Despite the arousal-dependent reduction in stimulus selectivity, frequency discrimination by cell ensembles improves due to a reduction in correlated variability (noise correlations).
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Head-restrained preparations have shown that behavioral state fluctuations have a strong impact on neuronal gain and coding properties in primary sensory areas and modulate neuronal firing within brain-wide neuronal networks.
“By employing head-restrained preparations, a growing body of work has demonstrated that behavioral state fluctuations have a strong impact on neuronal gain and coding properties in primary sensory areas36,43,66–70 and modulate neuronal firing within brain-wide neuronal networks44,71–74.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [68]
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Place and behavioral modulation of hippocampal neurons during immobility
Sartorato, N., Zouridis, I. S., Narantsatsralt, U.-U., Blanco-Hernández, E., & Burgalossi, A. (2026) · Nature Communications · doi:10.1038/s41467-026-75492-w · Cited by 1 · see citing works
- Authors
- Lin, P.-A., Asinof, S. K., Edwards, N. J., & Isaacson, J. S.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Isaacson, Jeffry S.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2019-11-22
- Volume
- 116
- Issue
- 50
- Pages
- 25304-25310
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6911239
- OpenAlex
- W2990271016
- Cited by
- 51
- References
- 33
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 4 · 2019: 1
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- HHS | NIH | National Institute on Deafness and Other Communication Disorders (R01DC04682, R01DC015239)
- National Science Foundation (NSFGRP)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Keywords
- arousal, primary auditory cortex, frequency tuning, lateral inhibition, layer 2/3, frequency discrimination, noise correlation, correlated variability, intracellular recording, brain states
- MeSH terms
- Action Potentials, Animals, Arousal, Auditory Cortex, Mice, Inbred C57BL, Neural Inhibition, Sound, Mice
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