The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
How tissue fluidity influences brain tumor progression
Open accessAbstract
Significance: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults, with one of the most dismal prognoses of all cancers. Yet, the reason why GBM grows so fast and aggressively is not understood. Our study provides an intriguingly simple explanation for the infiltrative behavior of GBM by looking at fluidity—a material property that quantifies the viscous behavior of biological tissues measured in vivo by magnetic resonance elastography. We show that fluidity of neurotumors is anomalous in that it decreases as water content increases, enabling GBM to infiltratively finger into normal surrounding brain matter. Fluidity might thus become an important target for cancer research and opens horizons for the diagnosis and treatment of cancer.
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Cites
Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807
Solid stress inhibits the growth of multicellular tumor spheroids
Helmlinger, G., Netti, P. A., Lichtenbeld, H. C., Melder, R. J., & Jain, R. K. (1997) · Nature Biotechnology · doi:10.1038/nbt0897-778 · Cited by 859
Cited by
Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy
Li, H., Kim, Y., Jung, H., Hyun, J. Y., & Shin, I. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00722c · Cited by 356
The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics
Elosegui-Artola, A. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.04.002 · Cited by 170
Rigidity transitions in development and disease
Hannezo, E., & Heisenberg, C.-P. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.12.006 · Cited by 69
Metadata
- Authors
- Streitberger, K.-J., Lilaj, L., Schrank, F., Braun, J., Hoffmann, K.-T., Reiss-Zimmermann, M., Käs, J. A., & Sack, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-12-16
- Volume
- 117
- Issue
- 1
- Pages
- 128-134
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2996744075
- Cited by
- 175
- References
- 2
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Streitberger, K.-J., Lilaj, L., Schrank, F., Braun, J., Hoffmann, K.-T., Reiss-Zimmermann, M., Käs, J. A., & Sack, I. (2020). How tissue fluidity influences brain tumor progression. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1913511116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
