The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components
Open accessAbstract
Significance: LLPS plays an important role in the spatiotemporal organization of the numerous molecular constituents of living cells, via formation of biomolecular condensates. Our simulations provide predictive rules governing the stability and composition of multicomponent biomolecular condensates. Biomolecules that increase the molecular connectivity of condensates are present in higher concentrations because connectivity is positively correlated with stability. Greater connectivity within highly multicomponent condensates manifests in higher critical temperatures in the phase diagrams of accessible systems involving just a few components. Hence, composition of highly multicomponent condensates can be predicted from the critical points of reduced-component mixtures. Our findings expand the mechanisms relating phase behavior of multicomponent intracellular mixtures to critical parameters (temperature, pH, salt concentration, etc.) of the constituent biomolecules.
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Biomolecular condensates: organizers of cellular biochemistry
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Cited by
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Surface electrostatics govern the emulsion stability of biomolecular condensates
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Self-citationGutierrez‐Beltran, E., Elander, P. H., Dalman, K., Dayhoff, G. W., Moschou, P. N., Uversky, V. N., Crespo, J. L., & Bozhkov, P. V. (2021) · The EMBO Journal · doi:10.15252/embj.2020105043 · Cited by 83
(2024) · doi:10.1038/s41467-024-47654-1 · Cited by 39
The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus**
Zhu, H., Narita, M., Joseph, J. A., Krainer, G., Arter, W. E., Olan, I., Saar, K. L., Ermann, N., Espinosa, J. R., Shen, Y., et al. (2023) · ChemBioChem · doi:10.1002/cbic.202200450 · Cited by 23
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Metadata
- Authors
- Espinosa, J. R., Joseph, J. A., Sanchez-Burgos, I., Garaizar, A., Frenkel, D., & Collepardo-Guevara, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2020-06
- Volume
- 117
- Issue
- 24
- Pages
- 13238-13247
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W3031487353
- Cited by
- 259
- References
- 73
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- green
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