The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The functional activity of E-cadherin controls tumor cell metastasis at multiple steps
Open accessAbstract
Significance: The expression of E-cadherin has been implicated in tumor metastasis, often as a tumor suppressor, but also as a promoter of growth and metastasis. We have shown that the functional activity of E-cadherin at the cell surface is often modified in response to environmental factors, and have developed monoclonal antibodies (mAbs) that activate E-cadherin adhesive function. These activating mAbs inhibit the metastasis of endogenous genetically driven mammary tumors in mice, and we dissect the process to show that these mAbs work at multiple steps of the metastatic cascade, including local invasion, intravasation, cell survival, and extravasation into the target organ. Thus, the functional state of E-cadherin is an important determinant of metastatic potential beyond whether the gene is expressed.
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Self-citationConvergence of Wnt, ß-Catenin, and Cadherin Pathways
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Epithelial-Mesenchymal Transitions
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Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program
Cheung, K. J., Gabrielson, E., Werb, Z., & Ewald, A. J. (2013) · Cell · doi:10.1016/j.cell.2013.11.029 · Cited by 833
E-cadherin is required for metastasis in multiple models of breast cancer
Padmanaban, V., Krol, I., Suhail, Y., Szczerba, B. M., Aceto, N., Bader, J. S., & Ewald, A. J. (2019) · Nature · doi:10.1038/s41586-019-1526-3 · Cited by 822
The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
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E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
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Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects
Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724
Metadata
- Authors
- Na, T.-Y., Schecterson, L., Mendonsa, A. M., & Gumbiner, B. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2020-03-03
- Volume
- 117
- Issue
- 11
- Pages
- 5931-5937
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W3009149445
- Cited by
- 441
- References
- 41
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- green
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